The invention discloses a soil erosion and nutrient migration simulating device applicable to Karst regions, which consists of a receiving pool, a cement plate and a bearing foundation trench, wherein a prefabricated steel baffle is respectively connected with the receiving pool and the cement plate, the cement plate is connected with the bottom of the receiving pool, a first drain pipe is connected with a first stainless steel tank, a second drain pipe is connected with a second stainless steel tank, a third drain pipe is connected with a third stainless steel tank, the bearing foundation tank is connected with the lower end of the cement plate, and the three stainless steel tanks are located in holes of the bearing foundation tank. Stainless steel drain pipes and handles are respectively reserved at the bottom end and the middle part outside each of the first, second and third stainless steel tanks. The device is simple in structure and convenient to operate, and simulates migration conditions of soil solutes under different rock crack environments, so that the problems that simulation study in water and soil process and water chemistry of the Karst regions is complex and difficult, hard to regulate and the like are solved.