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263 results about "Vitamin L2" patented technology
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Vitamin K2 or menaquinone (/ˌmɛnəˈkwɪnoʊn/) has nine related compounds, generally subdivided into the short-chain menaquinones (with MK-4 as the most important member) and the long-chain menaquinones, of which MK-7, MK-8 and MK-9 are nutritionally the most recognized.
Bacillus natto and application of Bacillus natto in fermentation production of vitamin K2
ActiveCN104328064AImprove oxygen supply capacitySuitable for mass productionBacteriaMicroorganism based processesVitamin K2Bacillus natto
The invention discloses bacillus natto which is classified and named bacillus natto and has been preserved in the China Center for Type Culture Collection with the preservation number of CCTCC M 2014405. The strain is extracted from a natto product purchased in the market and is obtained through ultraviolet mutagenesis and screening. By the use of the strain, soybean protein can efficiently be utilized to synthesize vitamin K2. The invention also discloses a method for producing vitamin K2 grease by the utilization of the above bacillus natto. According to the invention, a strain fermentation technology is optimized through a novel oxygen supply strategy, and fermentation cylinder scale-up is carried out. The final output of vitamin K2 reaches 60.54 mg / L. Conversion rate relative to soybean protein is 2.018 mg / g. Production costs are low. By the above method, efficient production of vitamin K2 grease can be realized; the whole process is simple; operation is convenient; production cycle is short; content of vitamin K2 is high; and fermentation cost is reduced. The method is suitable for industrial production.
Owner:ZHEJIANG BAISHANZU BIOTECH CO LTD
Nanoparticulate and controlled release compositions comprising vitamin k2
InactiveUS20110064803A1Reduces and eliminates developmentEliminate requirementsPowder deliveryBiocideVitamin K2Controlled release
The present invention is directed to compositions comprising a nanoparticulate vitamin K2 having improved bioavailability. The nanoparticulate vitamin K2 particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the prevention and treatment of osteoporosis. The invention also relates to a controlled release composition comprising a vitamin K2 or a nanoparticulate vitamin K2 that in operation delivers the drug in a pulsed or multi-modal manner for the prevention and treatment of osteoporosis.
Owner:ELAN PHRMA INT LTD
Vitamin K2 and preparation process thereof
ActiveCN103571897AHigh purityIncrease productionMicroorganism based processesFermentationVitamin K2Organic solvent
The invention discloses a vitamin K2 and preparation process thereof. According to the process, 1-hydroxyl-2-naphthoic acid resistant flavobacterium strain HNA12-D is fermented and cultured, and vitamin K2 efficiently metabolizes in the strain through the batch feeding of glycerin serving as the carbon source, peptone serving as the nitrogen source and precursor substances, and is extracted by using organic solvents and separated by macroporous resin, and the yield and purity of the product are improved. The total output of the vitamin K2 crude product is 200-600 mg / L after the flavobacterium strain HNA12-D of the invention is fermented and cultured for 120-144 hours, and the product purity reaches 80-99 percent after absorption chromatography; compared with the prior art, the yield output and the product purity are greatly improved, and the product can be used in industrial production.
Owner:HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
Method for producing vitamin K2 by utilizing bacillus natto
InactiveCN102808005AIncrease productionMicroorganism based processesFermentationVitamin K2Protoplast
The invention aims to disclose a method for producing vitamin K2 by utilizing bacillus natto. Protoplast fusion is conducted on bacillus natto BS-53 highly yielding the vitamin K2 and bacillus natto CICC10262 having a high growth speed but a low vitamin K content, and fusants with parent advantages are screened out; obtained high-yield strains having a high growth speed are utilized to produce the vitamin K2 under an optimized fermentation condition; and isopropanol and n-hexane are utilized to extract and separate the vitamin K2. The growth speed of the strains and the yield of the vitamin K2 is increased and an effective method is provided for scale production of the vitamin K2, thereby realizing the aim of the invention.
Owner:上海红马饲料有限公司
Method for improving yield of methane produced by anaerobic digestion of biomass raw materials
The invention discloses a method for improving output of methane produced by anaerobic digestion of inferior biomass raw materials, and belongs to the technical field of agricultural waste treatment. According to the method, various waste inferior biomass raw materials is used as a processing object, trace of electronic carrier hemin or vitamin K2 is added into an anaerobic reactor to improve the reducing force level of the whole fermentation system of biogas anaerobic fermentation so as to promote the growth and activity of hydrolytic acidification bacteria and methanogenic bacteria in the anaerobic digestion process, and the hydrolysis efficiency of the reaction system is improved, the anaerobic digestion time is shortened, and the yield of the methane and the conversion rate of the inferior biomass raw materials are improved. Due to the addition of extremely trace hemin and vitamin K2, industrial grade hemin and vitamin K2 are also applicable to the method, and the method has the advantages of simple operation and high efficiency and low cost, and is expected to be widely used in engineering practice.
Owner:JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
Barley and yam Natto
InactiveUS6669971B1Promote absorptionAvoid accumulationTea extractionAnimal feeding stuffVitamin K2Disease
The present invention provides Natto manufactured by mixing steamed soybean, cooked barley and yam, inoculating Bacillus subtilis Natto to the mixture, and fermenting the mixture, which is almost odorless, soft, good taste, and viscous, and further, functional substances such as vitamin K2 and enzyme (Nattokinase and Protease) are remarkably increased. This product may extend the utilization as functional traditional foods relating to prevention of life-style related disease.
Owner:OOYAMA TOFU
Bacillus natto culture extract
InactiveUS7018630B2High activitySolve the real problemCosmetic preparationsBacteriaVitamin K2FP extract
A Bacillus natto culture is treated with chitosan, and then filtered, concentrated, and dried. According to this method, a Bacillus natto culture extract containing nattokinase and 1 μg or less of vitamin K2 / g dry weight is obtained.
Owner:JAPAN BIO SCI LAB
Method for simultaneously producing vitamin K2 and nattokinase through Bacillus natto fermentation
ActiveCN106701719ASolve the problem of high cost and low outputIncrease profitMicroorganism based processesFermentationVitamin K2Microbiology
The invention discloses a method for simultaneously producing vitamin K2 and nattokinase through Bacillus natto fermentation. The method comprises the following steps: strain activation: performing streak culture on Bacillus natto in a plating culture medium, and culturing a single colony in a test tube culture medium; seed preparation: inoculating the Bacillus natto in the test tube into a seed culture medium, and culturing; production of nattokinase and vitamin K2: preparing fermentation culture medium for simultaneous production, taking the prepared seed solution after the fermentation culture medium for simultaneous production is cooled, inoculating, and producing the nattokinase and vitamin K2 under optimal culture conditions for simultaneous production; and separation and extraction of the nattokinase and vitamin K2: centrifuging the fermentation solution, separating the supernatant from the precipitate, adding inorganic high polymer flocculant into the supernatant, and taking chitosan as coagulant aid to separate the vitamin K2 and nattokinase in the supernatant. The method has the advantages of improving the raw material utilization ratio and being suitable for industrial production.
Owner:HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
Composition for increasing bone mineral density and preparation and preparation method thereof
InactiveCN105412569AGuaranteed reasonablenessImprove efficiencyOrganic active ingredientsPeptide/protein ingredientsVitamin K2Calcium in biology
The invention relates to a composition for increasing the bone mineral density and preparation and a preparation method thereof. The composition is mainly prepared from, by weight of parts, calcium carbonate, D-glucosamine hydrochloride, chondroitin sulfate, collagen protein, a casein phosphopepetides, a davallia mariesii extract and a vitamin K2. On the specific matched condition, the effect of remarkable synergistic interaction for treating osteoporosis is achieved, and the effects of blocking calcium loss and reinforcing calcium absorption are achieved; after traditional Chinese medicines of shaddock peels, chicken shells, purple bergenia herb and schisandra chinensis are added, the effect of increasing the bone density is further enhanced, and meanwhile the effects of treating the joint inflammation, tonifying the spleen and the kidney, strengthening tendons and bones, improving immunity and the like are achieved.
Owner:FUHESHOU WUHAN HEALTH MANAGEMENT
Bacillus subtilis natto for high yield rate of vitamin K2 (MK-7) and application thereof
ActiveCN108410775AIncrease productionStable outputBacteriaMicroorganism based processesMicroorganismVitamin K2
The invention discloses bacillus subtilis natto for high yield rate of vitamin K2 (MK-7) and application thereof, and belongs to the field of microorganisms. The bacillus subtilis natto ND-1-A27 was collected into China Center for Type Culture Collection on March 14, 2018 in Wuhan University of China, and the collection number is CCTCC NO:M 2018131. The bacillus subtilis natto has the advantages that the yield rate of the vitamin K2 (MK-7) is greatly increased and is about 70mg / L, and the maximum yield rate can be reached by about three days; the fermenting cycle is greatly shortened, the timeis shortened, and the cost is reduced; the bacillus subtilis natto can be applied to industrialized fermenting production, and the genetic stability is good; after five generations are continuously transferred, the yield rate of the vitamin K2 (MK-7) is basically stable, and is maintained at the higher level; the bacillus subtilis natto can be used as a production bacterial strain for further study and development.
Owner:JIANGNAN UNIV
Composition used for improving skeletal system health, and applications thereof
InactiveCN106235311AStructural influencePromote mineralizationOrganic active ingredientsPeptide/protein ingredientsVitamin K2Joint arthralgia
The invention belongs to the field of health care food, and especially relates to a composition used for improving skeletal system health, and applications thereof. The composition comprises skimmed milk powder, fructo-oligosaccharide, yak bone, orange fruit powder, D-glucosamine hydrochloride, bone collagen, chondroitin sulfate, herba epimedii extract, rhizoma drynariae extract, mushroom powder, magnesium carbonate, casein phosphopeptide, and vitamin K2. The composition possesses excellent prevention effects on patients with osteoporosis and skeletal system disorders such as ankylosis, arthritis, osteoproliferation, arthralgia, and myospasm, and is capable of increasing bone mineral density, and improving skeletal system health. The composition can be used for preparing health care food capable of improving skeletal system health; application range is wide; and economic benefit and social benefit are both high.
Owner:GUANGZHOU KOHEALA BIOTECHNOLOGY CO LTD
Method for synthesizing producets in vitamin K2 series
ActiveCN101092340AReduce isomerizationReduced responseOrganic compound preparationQuinone preparationVitamin K2Organic synthesis
This invention discloses a method for synthesizing vitamin K2 product. The method comprises: reducing 2-methyl-1, 4-naphthoquinone into hydroquinone by using KBH4, performing Fridel-Crafts alkylation reaction with long-chain tert-terpenol in nitromethane / n-hexane system with anhydrous ZnCl2, boron trifluoride diethyl etherate and CuBr as the catalysts to introduce long-chain terpenyl to the C3 site of hydroquinone, oxidizing with isopropanol solution of FeCl3 to obtain corresponding vitamin K2. The method has such advantages as mild reaction conditions, high yield, recoverable reagents, and no environmental pollution.
Owner:广东固升医药科技有限公司
Method for efficiently producing vitamin K2 by flavobacterium
InactiveCN103290077ARaise the level of fermentationEasy to useMicroorganism based processesFermentationVitamin K2Biotechnology
The invention discloses a method for efficiently producing vitamin K2 by flavobacterium. High-producing strains are bred by means of composite mutagenesis through a low-energy ion beam and a low-temperature plasma after original strains of the flavobacterium are activated on culture media, fermentation units of the high-producing strains are increased by 50-100% through preliminary screening and shake flask fermentation secondary screening of an analog flat plate with the vitamin K2, intracellular vitamin K2 is dissolved to an extracellular environment by adding surface active agents when the flavobacterium is fermented, and the yield of the vitamin K2 is improved by 50-200%. By the aid of the method, the fermentation level of the vitamin K2 can be greatly improved, high-efficiency biosynthesis of the vitamin K2 is realized, large-scale industrialized fermentation of the vitamin K2 is possible, and the method is convenient to use.
Owner:HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
Child milk powder for promoting bone growth and preparation method thereof
The invention belongs to the field of dairy products, and particularly relates to child milk powder for promoting bone growth and a preparation method thereof. The milk powder comprises the followingcomponents in parts by weight: 3000-4000 parts of raw cow milk or raw goat milk, 100-200 parts of skim milk powder, 100-200 parts of desalted whey powder, 30-80 parts of composite vegetable oil or 1,3-dioleic acid-2-palmitic acid triglyceride, 50-150 parts of solid corn syrup, 50-150 parts of whey protein powder, 30-100 parts of crystalline fructose, 20-50 parts of fructo-oligosaccharide, 10-30 parts of anhydrous cream, 5-20 parts of galacto-oligosaccharide, 1-3 parts of compound vitamin, 1-3 parts of compound mineral and 2.2-9 parts of a calcium promoting component. By adding casein phosphopeptides, hydrolyzed yolk powder, vitamin K2 powder and other components, the calcium content is increased, and the absorption and utilization rate of calcium can be effectively increased; and by combining with probiotics, dietary fibers and other nutritional ingredients, the bone growth of children can be effectively promoted, the immunity is improved, and the growth requirements of the children are met.
Owner:北安宜品努卡乳业有限公司
Nutritional composition for promoting musculoskeletal health in patients with inflammatory bowel disease (IBD)
ActiveUS9561194B2Good for healthHeavy metal active ingredientsVitamin food ingredientsVitamin K2Alpha-Linolenic acid
Owner:SOC DES PROD NESTLE SA
Vitamin K2 compound for preventing and treating arthritis
InactiveCN103705527ASignificant reliefSignificant inhibitoryOrganic active ingredientsSkeletal disorderVitamin K2Treatment effect
The invention provides a vitamin K2 compound for preventing and treating arthritis, and belongs to the field of medicine or health-care food formulae. Per 1000g of the compound comprises 0.05-0.25g of vitamin K2, 0.005-0.01g of vitamin D, 500-750g of glucosamine and 499.945-249.740g of solid or liquid matrix. The compound which is mechanically stirred and uniformly mixed under a normal temperature or heating condition is prepared to soft capsules, hard capsules or troches. The medicine or health-care food formed by the formula has remarkable preventing and treating effects on common osteoarthritis of the middle aged or the aged people, especially postmenopausal women.
Owner:昆明云大医药开发有限公司
Menadione-7(MK-7) high-yielding strain and application thereof
InactiveCN103865835AHigh production of MK-7BacteriaMicroorganism based processesVitamin K2Industrial fermentation
The invention relates to a strain of bacillus amyloliquefaciens capable of generating a great amount of MK-7 (menadione-7) in a culture process and a culture method thereof. The name of the strain is Y-2, and the class name is bacillus amyloliquefaciens. The obtained strain has stable hereditary character and stable yield trait, is suitable for industrial popularization, and is collected in the China Center for Type Culture Collection (CCTCC), with the collection number CCTCC No.M2013493. The invention also discloses a method for producing MK-7, which comprises the following steps: with 5% of seed inoculation amount, inoculating a seed solution into a fermentation medium; culturing for 2 hours at a rotation speed of 100r / min and a temperature of 37 DEG C; performing stationary culture for 6 days, wherein the highest yield of vitamin K2 (MK-7) reaches 66.62mg / L. According to the MK-7 high-yielding strain and production method provided by the invention, the production cycle is short, the yield is high, and feasibility is provided to the production of MK-7 through industrial fermentation.
Owner:JIANGNAN UNIV
Health products for osteoporosis and cardio-cerebrovascular disease using walnut oil as matrix
ActiveCN101283796ANo side effectsSafe to takeSkeletal disorderFood preparationVitamin K2Treatment effect
The invention relates a preparation containing organic effective components and having curative and healthy functions on osteoporosis and cardiovascular and cerebrovascular diseases. The preparation is prepared by mixing vitamin K2 0.01 to 0.5 g with coenzyme Q10 5 to 10 g, heating with walnut oil 300 g at 40 DEG C, stirring to dissolve, adding walnut oil 599.5 to 694.99 g under stirring, and mixing uniformly to obtain a mixed solution 1000 g. The solution can be further packaged to soft capsule or hard capsule, and the vitamin K2 is one or a plurality of kinds of vitamin K2 (5) to K2 (50). The preparation can be used for prevention and assistant treatment of the cardiovascular disease, and has the healthy and the curative effects on increasing bone density and resisting osteoporosis.
Owner:广东固升医药科技有限公司
Vitamin K2 high-yielding strain
The invention aims to disclose a vitamin K2 high-yielding strain. Compared with the prior art, bacillus natto BS-5 is taken as an original strain, after the ultraviolet and nitroso arc composite mutation, the mutant strain BS-53 is obtained after screening, the mutant strain BS-53 and bacillus natto CICC (China center of industrial culture collection)10262 which has low vitamin K2 yield but high growth rate, are subjected to protoplast fusion, fusant is obtained through the screening of a flat screen, and the fusant is finally obtained after the selecting of the fermenting property experiment; and the vitamin K2 high-yielding strain has excellent characteristics of parents, i.e. has the dual effects of high MK (midkine) yield and high growth rate, an effective method is provided for realizing high MK yield, important scientific meaning and application value are obtained, and the purpose of the invention is realized.
Owner:上海红马饲料有限公司
Nose bleed treatment system
A nose bleed treatment system for use in treating a patient having a nose bleed uses a nose clip that resiliently clamps the patient's nostrils to provide pressure to help stop the bleeding. A medically effective agent is sprayed in the patient's nostril using a spray bottle that has an elongated tip to apply the agent close to the source of the bleed. The medically effective agent contains at least one of a clot enhancing agent and a vasoconstricting agent. The agent may contain vitamin K as well as a vasoconstricting agent epinephrine with pytonadione (vitamin K1), menaquinone (vitamin K2), menadion (vitamin K3) fibrogen or other suitable medications. The medically effective agents are preferably herbally or mammalian sourced.
Owner:HUSAIN ABBAS M
Bacillus subtilis natto recombinant bacteria and construction method and application thereof
The invention discloses bacillus subtilis natto recombinant bacteria and a construction method and application thereof, and belongs to the technical field of genetic engineering. According to the system, it is the first attempt to utilize a CRISPR-CAS gene editing technology for knockout of key enzymes ubiA and aroH in a by-product feedback metabolic pathway, expression of key enzyme genes menA, menC and menD is enhanced on genomes, gamma-polyglutamic acid is obtained while the concentration of vitamin K2(MK-7) is increased, the concentration of the gamma-polyglutamic acid reaches a high level, and a new idea of combined production of the vitamin K2(MK-7) and the gamma-polyglutamic acid is provided.
Owner:JIANGNAN UNIV
Calcium tablet containing vitamin K2 and preparation method thereof
ActiveCN107375221AMake up for the shortcomings of constipationReduce the chance of occurrenceOrganic active ingredientsMetabolism disorderVitamin K2Constipation
The invention belongs to the technical field of healthcare products and specifically relates to a calcium tablet containing vitamin K2 and a preparation method thereof. The calcium tablet comprises the following components in parts by weight: 40-60 parts of calcium carbonate, 0.5-1 part of vitamin D, 5-6 parts of vitamin K2, 2-3 parts of inclusion agent, 2-4 parts of absorption promoter, 20-30 parts of maltodextrin, 2-4 parts of sodium carboxymethylcellulose and 1-3 parts of water. The calcium tablet disclosed by the invention is capable of promoting the calcium absorption and conversion, has an excellent calcium-supplementing effect and is capable of reducing constipation caused by the calcium source of calcium carbonate.
Owner:富诺健康股份有限公司
Stable vitamin K2 submicron emulsion and preparing method
InactiveCN106074377AImprove stabilityFreeze-thaw toleranceOrganic active ingredientsSkeletal disorderFreeze thawingEmulsion
Vitamin K2 submicron emulsion is prepared from, by weight, 0.0005-1% of vitamin K2, 1.0-10% of oil, 0.1-1.2% of phospholipid, 0.5-2.3% of emulgator, 0.5-3.0% of antifreezing agent and water according to the total weight of the vitamin K2 submicron, wherein emulgators except phospholipid can serve as the emulgator in the emulsion. The vitamin K2 submicron emulsion is good in sterilization stability and freeze-thaw stability, and the expected shelf life can reach two years or more.
Owner:SUNGEN BIOSCIENCE CO LTD
Method for measuring content of vitamin K2 (MK-7)
ActiveCN104458990AExtended service lifeShort test timeComponent separationChromatographic separationVitamin K2
Owner:JIANGSU ALAND NOURISHMENT
Arthralgia relief composition, arthralgia relief health-care product, and application of arthralgia relief composition
ActiveCN110051822ARelief the painPrevent degenerative changesOrganic active ingredientsHydrolysed protein ingredientsDegenerative changeVitamin K2
The invention discloses an arthralgia relief composition, an arthralgia relief health-care product, and application of the arthralgia relief composition. The arthralgia relief composition comprises D-glucosamine sulfate potassium chloride, calcium carbonate, chondroitin sulfate, type II collagen, non-denatured type II collagen, turmeric extract, vitamin K2 powder, and vitamin D3 powder. Human feeding trials prove that the components are synergistic, allowing arthralgia to be relieved shortly, promoting joint activity improvement, and preventing further degenerative changes in articular cartilages; the arthralgia relief composition has good safety and effect, and a quick, effective scheme is provided for relief of osteoarthritis or rheumatoid arthritis pains.
Owner:BY HEALTH CO LTD
Composition for an anti-aging treatment
An anti-aging composition comprising: pinebark extract, polypodium leucotomos, ashwagandha extract, dehydroepiandrosterone, white tea extract, alpha lipoic acid, vitamin K2, bioactive silicon, hyaluronic acid, trimethylglycine, and optionally, piperine, green tea extract, folic acid, vitamin C, camu camu, and blueberry extract.
Owner:PARHAM TABIBIAN MD INC
Organic fertilizer formula for significantly improving fertilizer utilization rate
The invention discloses an organic fertilizer formula for significantly improving fertilizer utilization rate. The organic fertilizer formula comprises, by weight, 5-10 parts of soybean oligosaccharide, 84.99-92.995 parts of an organic material containing 16% fulvic acid, 2-5 parts of a 5% polyglutamic acid liquid agent, and 0.005-0.01 parts of vitamin K2. With the present invention, the problems of soil hardening, reduction of the yield increasing effect of the fertilizer, agricultural product quality decreasing, environmental pollution, and the like due to excessive chemical fertilizer utilization are effectively solved; the organic fertilizer of the present invention has characteristics of stable performance, simpleness and feasibility, and low cost, and is applicable for popularization and application in a large area; the agricultural sustainable development can be effectively promoted.
Owner:QINGDAO BENDA AGRI TECH
Pre-mixed feed for improving bone density and eggshell quality of laying hens and preparation method thereof
InactiveCN109123181APromote absorptionBroaden the formation processFood processingAnimal feeding stuffVitamin K2Eggshell
The invention provides a pre-mixed feed for improving the bone mineral density and eggshell quality and a preparation method thereof, belonging to the technical field of egg chicken feed. The method comprises the following components in parts by weight: 130-170 parts of calcium hydrogen phosphate, 100-160 parts of stone powder, 100-150 parts of shell powder, 10-40 parts of calcium malate, 20-27 parts of calcium hydroxymethionine, 0.5-2 parts of lactobionic acid, 0.5-2 parts of agaricus blazei and 0.5-2 parts of colostrum alkaline protein, 2-5 parts of hydroxyl vitamin D, 2-8 parts of phytase,2-5 parts of composite enzyme preparation, 2-5 parts of microecological agent, 0.1-0.4 parts of soybean flavone, 0.1-0.4 parts of vitamin K2, 0.5-2 parts of bone collagen, 1-4 parts of polydextrose, 0.5-2 parts of fructo-oligosaccharide, 0.5-2 parts of rhizoma drynariae, 0.5-2 parts of fructus psoraleae and the like. In order to improve the calcium utilization rate, a brand new idea of calcium utilization is provided, that is, three systems of the calcium supplement of the laying hens, that is, a calcium supplementing system, a calcium promotion absorption system and a health system of improving the gastrointestinal.
Owner:播恩集团股份有限公司
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