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Composition for increasing bone mineral density and preparation and preparation method thereof

A technology for increasing bone density and composition, applied in the field of pharmaceutical preparations, can solve the problems of single function, single action route, low bioavailability, no prevention, etc., achieve synergistic treatment of osteoporosis, improve immunity, increase bone The effect of density

Inactive Publication Date: 2016-03-23
FUHESHOU WUHAN HEALTH MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these products have single functions and pathways of action, have no preventive effect on middle-aged and elderly people suffering from osteoporosis and accompanying osteoarthritis, bone pain and other orthopedic diseases, and have low bioavailability and poor stability, which cannot satisfy the needs of people. multiple needs

Method used

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  • Composition for increasing bone mineral density and preparation and preparation method thereof
  • Composition for increasing bone mineral density and preparation and preparation method thereof
  • Composition for increasing bone mineral density and preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A composition for increasing bone density, which is prepared by processing the following raw materials in parts by weight: calcium carbonate 20, D-glucosamine hydrochloride 28, chondroitin sulfate 21, bone collagen 15, casein Phosphopeptide 16, drynaria extract 17, vitamin K 2 10.

Embodiment 2

[0029] A composition for increasing bone density, which is prepared by processing the following raw materials in parts by weight: calcium carbonate 20, D-glucosamine hydrochloride 25, chondroitin sulfate 20, collagen 14, casein Phosphopeptide 13, Rhizoma Drynaria Extract 22, Vitamin K 2 13. Pomelo peel 12, chicken shell 25, rock cabbage 8, schisandra 16.

Embodiment 3

[0031] A composition for increasing bone density, which is prepared by processing the following raw materials in parts by weight: calcium carbonate 15, D-glucosamine hydrochloride 20, chondroitin sulfate 18, bone collagen 12, casein Phosphopeptide 10, drynaria extract 15, vitamin K 2 8; the preparation method of the drynaria extract is:

[0032]1) drynaria rhizome raw material, add the solvent of 35 times of raw material weight parts and carry out reflux extraction three times, extract 3, 2, 1.5 hours respectively, described solvent is the methanol: ethanol: the mixed solvent of water that mass ratio is 1:5:2 ;

[0033] 2) The extracts are filtered and combined, concentrated under low temperature and reduced pressure until alcohol-free, and the obtained crude drug aqueous solution is extracted four times with an equal volume of hot ether, after combining the organic phases, concentrated under low temperature and reduced pressure, and dried in vacuum to obtain Drynaria rhizome...

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PUM

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Abstract

The invention relates to a composition for increasing the bone mineral density and preparation and a preparation method thereof. The composition is mainly prepared from, by weight of parts, calcium carbonate, D-glucosamine hydrochloride, chondroitin sulfate, collagen protein, a casein phosphopepetides, a davallia mariesii extract and a vitamin K2. On the specific matched condition, the effect of remarkable synergistic interaction for treating osteoporosis is achieved, and the effects of blocking calcium loss and reinforcing calcium absorption are achieved; after traditional Chinese medicines of shaddock peels, chicken shells, purple bergenia herb and schisandra chinensis are added, the effect of increasing the bone density is further enhanced, and meanwhile the effects of treating the joint inflammation, tonifying the spleen and the kidney, strengthening tendons and bones, improving immunity and the like are achieved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a composition for increasing bone density and its preparation and preparation method. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a systemic skeletal disease caused by a variety of reasons, which is characterized by decreased bone mass, decreased bone density, and degeneration of bone tissue microstructure, leading to increased bone fragility and age-related deterioration. A degenerative bone disease that occurs with an increase. Osteoporosis is an senile disease, the incidence of which is higher in women than in men, and is caused by bone metabolism disorders caused by various reasons. Bone mineral density is an important marker of bone quality, reflects the degree of osteoporosis, and is an important basis for predicting osteoporotic fractures. As a disease of modern civilization, osteoporosis has become one of the important public health proble...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K38/39A61P19/10A61P19/02A61P37/04A61K31/737A61K31/7008A61K38/17A61K31/122A61K36/126A61K36/752A61K36/79A61K35/57
CPCA61K36/804A61K9/2054A61K9/28A61K9/2866A61K31/122A61K31/7008A61K31/737A61K33/10A61K35/57A61K36/07A61K36/076A61K36/126A61K36/14A61K36/185A61K36/232A61K36/258A61K36/288A61K36/515A61K36/537A61K36/57A61K36/69A61K36/725A61K36/752A61K36/79A61K36/808A61K36/8965A61K36/8968A61K38/1709A61K38/39A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 李耀东李连成
Owner FUHESHOU WUHAN HEALTH MANAGEMENT
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