137 results about "Thyroid disease" patented technology

The present invention relates to methods for predicting or diagnosing a thyroid disease in an individual.

The invention relates to a thyroid CT image computer-aided diagnosis system and method. The problem that currently, many defects exist in the thyroid disease diagnosis through physical examination, ultrasonic scanning and radioisotope scanning is solved. The system comprises an input module, an image texture characteristic extracting module, a classified diagnosis module and an output module which are sequentially connected. The method includes the steps of conducting outline segmenting and extracting on an image, then conducting texture characteristic analysis on the image to obtain the 28-dimension texture characteristic, and finally substituting the 28-dimension texture characteristic into a diagnosis model to obtain a diagnosis result and a statistics index. The thyroid CT image computer-aided diagnosis system and method have the advantages that non-invasiveness, rapidness and timeliness are achieved; no chemical reagents or the like are needed, and cost is low; complexity of a lesion thyroid texture characteristic sample set is effectively reduced, and identification accuracy can be further improved; the result is not affected by man-made subjective factors and is prevented from being affected by man-made subjective factors in the pathological examination and other examinations.

The invention relates to an auxiliary diagnostic kit of thyroid diseases, and discloses a tetraiodothyroxide test kit which comprises tetraiodothyroxide testing particles, tetraiodothyroxide resisting antibody marked by biotin and disintegrating agent; wherein triiodothyronine testing particles are luminous particles coated by diiodothyronine, and the disintegrating agent is 8-anilino-1- naphthalenesulfonic acid ammonium salt hydrate. The invention also discloses a use method of a triiodothyronine kit. The kit can be combined with other serum and clinical information for the auxiliary diagnosis of thyroid diseases and the monitoring of the treatment effect of relevant patients.

The invention relates to an aided diagnostic reagent of thyroid diseases and discloses a detection micro particle of thyroid stimulating hormone, which is a luminous micro particle coated by an antithyrotropic hormone antibody. The invention also discloses preparation and application of the thyroid stimulating hormone. In addition, the invention further discloses a vitro diagnostic kit of the thyroid stimulating hormone in a determined sample. Meanwhile, the invention discloses a using method of the kit. The kit can be combined with other serums and clinical information for aided diagnosis of the thyroid diseases and the monitoring of treatment effect of related patients.

The invention discloses a thyroid nodule recognition method based on a generative adversarial network. The thyroid nodule recognition method comprises the following steps: screening the data of a patient suffering from a thyroid disease, building a thyroid nodule database, and carrying out circling marking on thyroid nodules and thyroid parenchyma; semantic segmentation: taking U-net as a condition of a generative network to generate an adversarial network model, and inputting an annotated image to realize semantic segmentation; benign and malignant classification input: after multiple convolution, activation and pooling, using a full connection layer to integrate the extracted features to realize image benign and malignant judgment by the convolutional neural network; after the lesion isinput into the convolutional neural network, automatically classifying the lesion and outputting a benign and malignant judgment result of the lesion by the convolutional neural network; and giving areference diagnosis report of the illness state of the patient according to the training result. The thyroid nodule recognition method based on a generative adversarial network can improve thyroid nodule benign and malignant judgment accuracy of doctors, can reduce the thyroid screening time of ultrasound, can reduce the working intensity of medical staff, and can increase the satisfaction degreeof patients.

This invention provides a human hypothyroid peroxid enzyme antibody magnetic separation enzyme immune measurement method, whose steps are the following: to add sample to react with immune; to wash and to join two anti-enzyme indicate reagent and to wash again; to add monophosphatase fenolftaleina substrate solvent; to terminate color forming and to read absorbing value. The advantages in this invention are the following: it uses reformed human hypothyroid peroxid enzyme antigen fold immune magnetism micro ball as fixed phase and uses alkalescence phosphate enzyme as mark enzyme. Through the quantitative measurement of peroxid enzyme antigen of the hypothyroid patient and normal serum and other clinic symptom, it can judge whether the patient has got the self-immune hypothyroid illness.

The invention provides a thyrotropin (TSH) chemiluminescent immunoassay quantitative detection kit and a preparation method thereof. The invention has the advantages that the reaction pattern of the double antibody sandwich method is adopted, the chemiluminescent technology combining with the technology of fluorescin isothiocyanate-anti-fluorescein isothiocyanate is effectively utilized, horse radish peroxidase is adopted to be as the marker enzyme to quantitatively detect the content of TSH in the human serum sample, the detection sensitivity is guaranteed, and the raw materials are greatly saved. The kit of the invention has high sensitivity, good repeatability, short reaction time, good stability and long reagent validity, and can provide the experimental basis timely for the clinical diagnosis and the treatment of thyroid disorders.

The invention provides a chemiluminescent immunoassay kit for thyroid peroxidase autoantibodies and a preparation method thereof. The invention has the advantages that the reaction pattern of the double antigen sandwich method is adopted, the chemiluminescent technology and the biotin-avidin immune amplifying technological principle are effectively utilized, horse radish peroxidase is adopted to be as the marker enzyme, the content of the thyroid peroxidase autoantibodies in human serum samples is quantitatively detected, and the detection sensitivity can be ensured. The kit of the invention has the advantages of high sensitivity, good repeatability, good stability and high detection efficiency, and can provide a timely and reliable experimental basis for the clinical diagnosis and the treatment of thyroid disorders.

Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.

The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders.

The invention discloses an operation pillow for a thyroid disease. The operation pillow comprises a bottom plate; a jugalar plate is arranged on the bottom plate; a first airbag is arranged on the jugalar plate; the operation pillow for the thyroid disease enables a patient to more comfortably lie through the first airbag and a second airbag; as the second airbag is designed into an elliptical column shape, the position of a neck is heightened, so that a doctor is wider in visual field during operation; a first electric telescopic rod is arranged on equipment, and a head of the patient can be moved at any moment through the first electric telescopic rod, so that the patient can be more comfortably operated; a second electric telescopic rod is also arranged on the equipment, and the head of the patient can be clamped through the second electric telescopic rod to prevent the patient from moving back and forth during operation; a table lamp is also arranged on the equipment, and the doctor can see more clearly during operation through the table lamp; the equipment is simple in structure, and the height of the surgical pillow for the thyroid disease can be freely adjusted; meanwhile, the best visual field during operation can be displayed.

The invention relates to an auxiliary diagnosis reagent kit of thyroid diseases, which discloses a triiodothyronine detection reagent kit. The triiodothyronine detection reagent kit comprises triiodothyronine detection particles, biotin marked anti-triiodothyronine antibodies and dissociation agents, wherein the triiodothyronine detection particles are diiodothyronine covered luminous particles, and the dissociation agents are 8-anilino group-1-ammonium naphthalenesulfenesulfonate. The invention also discloses a use method of the triiodothyronine detection reagent kit. The reagent kit of the invention can be combined with other blood serum and clinic information to be used for auxiliary diagnosis on the thyroid diseases and the monitoring on the relevant patient treatment effect.

The invention provides a recipe of a traditional Chinese medicine innovation integrated therapy for thyroid diseases. The recipe is characterized by comprising an external use recipe including 10g Chinese violet, 10g dandelion, and 10g honeysuckle flowers, as well as an internal use recipe including 5g codonopsis pilosula, 5g salviae miltiorrhizae, 5g cuttlebone, 5g ligusticum wallichii, 5g kelp, 5g fritillary bulb, 3g radix bupleuri, 8g dandelion, 5g selfheal, 5g angelica roots, 15g oysters, 3g costusroot, 5g malt, 5g astragalus membranaceus, 5g viola philippica and 5g liquorice. The recipe of the traditional Chinese medicine innovation integrated therapy for the thyroid diseases has a good effect and ensures zero recurrence after withdrawal.

The invention provides a thyroid disease diagnosis method based on an SPECT image. A convolutional neural network with an improved DenseNet network structure is used for image classification. Parameters influencing the weight are added to cross-layer connection in a Dense block, and the weight of the feature map of each layer is dynamically adjusted in training, so that the network has higher flexibility and the classification performance is improved. Implementations show that the method can achieve better performance than other deep learning methods. The method can be widely applied to thyroid disease diagnosis and other image classification problems.

The present invention relates to a pharmaceutical composition for preventing or treating thyroid diseases and a food composition for improving thyroid function, comprising an extract from Lonicera caerulea L. car. Edulis fruits as an active ingredient.The composition of the present invention may be useful for preventing or treating thyroid diseases such as hypothyroidism, hyperthyroidism, thyroid nodule, or thyroditis, and improving thyroid function. Since the extract from Lonicera caerulea L. car. Edulis fruits, which is an active ingredient of the present invention, is derived from natural products, there is no concern for side effects such as toxicity compared to synthetic medicine.

The present invention is based upon the discovery that mutant alpha subunits and mutant beta subunits each comprising amino acid substitutions relative to the wild type can be produced and assembled to form a mutant TSH heterodimer or TSH analog that possesses higher bioactivity in vitro and longer half life in vivo. Accordingly, the present invention provides methods for using mutant TSH heterodimers, TSH analogs, fragments, and derivatives thereof for treating or preventing diseases of the thyroid, in particular thyroid cancer. The invention also relates to methods of diagnosis, prognosis and monitoring for thyroid-related functions. Pharmaceutical and diagnostic compositions, methods of using mutant TSH heterodimers and TSH analogs with utility for treatment and prevention of metabolic and reproductive diseases are also provided.

The invention discloses application of entacapone to prevention or treatment of obesity and other metabolic syndromes. Specifically, the invention discloses application of entacapone as shown in the formula I or a pharmaceutically acceptable salt thereof to preparation of medicaments for the prevention and / or treatment of metabolic diseases, cardiovascular and cerebrovascular diseases, as well as liver, kidney and thyroid diseases induced therefrom. The metabolic disease is selected from obesity, diabetes and hyperlipidemia; the cardiovascular and cerebrovascular disease is selected from hypertension, coronary heart disease, and atherosclerosis. The prevention and / or treatment of obesity refers to inhibition of body weight increase or promotion of weight loss. The blood lipid is selected from the group consisting of low density lipoprotein, low density lipoprotein-cholesterol, cholesterol and triglyceride. The renal disease is selected from diabetic nephropathy. (img file = 'DDA00002485677700011.TIF' wi = '1113' he = '654' / ).

The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders.

A method for therapeutically treating medical conditions requiring chronic therapy such as fibrocystic breast disease, endometriosis, ovarian cysts, uterine fibroids and including the treatment of women considered to be at risk to breast and / or ovarian cancer without causing an overt thyroid disease by first administering to a patient a daily loading dose of molecular iodine (I2) for a time period not to exceed six months and preferably 2 to 4 months at a concentration level sufficient to remediate symptoms associated with the medical condition followed by daily dosing with a maintenance dose of I2 after treatment of the loading dose is completed with the concentration of the maintenance dose being substantially less than the concentration of the loading dose.

This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of thyroid hormones and related antibodies in a serum sample, which can be used to evaluate thyroid functions and to diagnose thyroid diseases. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies and antigens used for the detection of respective thyroid hormones and related antibodies in a serum sample.

The invention discloses a surgical pillow for thyroid diseases. The surgical pillow comprises a back pillow, a headrest and a fixing base, wherein the upper end of the fixing base is provided with a notch, the inner bottom end of the fixing base is fixedly installed with a lifting mechanism, the lifting mechanism comprises a motor, the motor is fixedly installed on one side of the outer wall of the fixing base by a bolt, a power output end of the motor penetrates the fixing base and is fixedly connected with a threaded screw, the surface of the outer wall of the threaded screw is provided withleft-handed threads and right-handed threads, the left-handed threads are located at one ends of the right-hand threads, and threaded sliding sleeves are installed outside the left-hand threads and the right-hand threads in a slide manner respectively. Through the installed lifting mechanism, the adjustment can be performed according to the actual height of a patient, so that the headrest can reach the best position, and thereby not only the comfort of the patient can be improved, but also a height of the headrest can be adjusted conveniently and quickly to thereby adjust a height of the headand neck to adapt to operations of different operations and examinations.

The invention discloses a thyroid nuclear medicine image diagnosis method based on deep learning, and belongs to the technical field of information. The problem that thyroid nuclear medicine image diagnosis is limited to a certain extent and the diagnosis efficiency is low in the prior art is solved. The method comprises the following steps: determining an ROI area by using a three-channel threshold detection method, and cutting pictures; performing scaling, rotation and Gaussian noise addition processing on the focus image set to form an extended sample data set; establishing a convolutionalneural network for image diagnosis, and training the network by using the training set to obtain a trained novel diagnosis model; performing disease diagnosis on the test set by using the trained diagnosis model to obtain a thyroid disease diagnosis result of each medical image. According to the method, the trained model has higher robustness, and the popularization possibility of the model in hospitals is enhanced.

The invention relates to mesenchymal stem cells from canine fetal membranes, a preparation method and a used culture medium. The mesenchymal stem cells from the canine fetal membranes are prepared bythe method including the following steps of: disinfection and cleaning, digestion treatment, cell culture, cell passage and cell cryopreservation. The method for preparing the mesenchymal stem cells from the canine fetal membranes shows excellent technical effects, and by the used culture medium, the efficiency of preparation of the stem cells can be greatly improved. The prepared mesenchymal stemcells has the beneficial effect of treating arthritis, bone fracture, muscle injury, ligamentous injury, cartilage injury, joint injury, cognitive disorder, immunologically mediated diseases, xerophthalmia, recurrent uveitis, liver diseases, heart disease, kidney disease, diabetes, gastrointestinal disease, thyroid disease and skin disease of canine animals.

The present disclosure relates to a compound and method of using such compound preferably in the form of a dietary supplement that, when administered, is capable of treating thyroid disease and various thyroid-related disorders. The unique combination of the composition is preferably administered orally. The composition is preferably comprised of at least selenium, zinc, iodine, manganese, molybdenum, ashwaganda root powder, polygonum root extract, a digestive enzyme such as DPP-IV, L-tyrosine and mullein leaf, in pre-determined amounts. The composition can further comprise a palliative agent, and can be provided in the form of a capsule or tablet.

The invention discloses a human body thyroid weight measuring method based on SPECT (Single Photon Emission Computed Tomography) planar imaging, and mainly solves the problem in an existing thyroid weight measuring method that an error is big and efficiency is low since an area of interest is manually drawn. The method comprises the following implementation steps of: (1) inputting a planar imaging graph of the thyroid; (2) carrying out graying on the planar imaging grahp of the thyroid; (3) carrying out binaryzation on the planar imaging graph of the thyroid; (4) extracting the area of interest; (5) calculating the area of the area of interest; (6) calculating the longest diameters of the left and right half leaves of the area of interest; and (7) calculating the quality of the thyroid. The method has the advantages that the integrity of the SPECT planar imaging graph can be guaranteed, the area of interest is effectively segmented, feature information is extracted and the weight of the thyroid is quickly calculated. The thyroid weight measurement can be efficiently finished under a situation that the accuracy is guaranteed, and the method can be used for estimating a drug dosage according to the weight of the thyroid in clinic thyroid disease treatment.

The invention discloses a method for removing a small-molecule substance from serum, in particular thyroid hormone removing serum, a preparation method thereof, and a human total triiodothyronine and free thyronine detection kit comprising the thyroid hormone removing serum. The thyroid hormone removing serum in the invention is obtained by activated carbon adsorption of glucan-treated serum. The human total triiodothyronine and free thyronine detection kit in the invention has the advantages of high detection sensitivity, high specificity, high result stability and the like, so as to be applicable to clinical auxiliary diagnosis screening for thyroid diseases on a large scale.

Kits, compositions, and methods useful in the diagnosis of thyroid diseases involving autoantibodies are provided.

The present invention provides novel compounds of the Formula I and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1 to R8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, overweight condition, hyperlipidemia, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression, osteoporosis, cardiac arrhythmias, glaucoma and congestive heart failure are also provided.