The invention discloses a preparation method of
ceftriaxone sodium, which comprises the following steps: carrying out earlier-stage treatment on AE active ester and 7-ACT to respectively obtain a first
mixed solution, a second
mixed solution and a third
mixed solution, and simultaneously adding the third mixed solution, the second mixed solution and
triethylamine into the first mixed solution to obtain a first reaction solution; adding a
sodium hydroxide aqueous solution,
sodium metabisulfite and EDTA into the first reaction solution, conducting stirring to obtain a second reaction solution, adding
dichloromethane into the second reaction solution, conducting standing for
phase splitting to obtain a
dichloromethane phase and a water phase, adding
activated carbon into the water phase for decoloration, conducting
vacuum pumping, and then conducting filtering through a
decarburization filter to obtain a to-be-crystallized liquid of
ceftriaxone acid; treating the
ceftriaxone acid to-be-crystallized liquid to obtain a ceftriaxone acid wet product; then obtaining a to-be-crystallized liquid of
ceftriaxone sodium; and adding an
acetone solution of
methanol into the to-be-crystallized liquid of
ceftriaxone sodium for
crystallization, and conducting filtering, washing and
drying to obtain a finished product of
ceftriaxone sodium. According to the invention, high-quality ceftriaxone sodium can be obtained.