42 results about "Heme iron" patented technology

The invention discloses a comprehensive nutrition powder for reducing fat, lowering blood sugar, lowering blood pressure and lowering blood fat, and a preparation method thereof. The comprehensive nutrition powder comprises nutrients most easily deficient in modern people, auxiliary nutrients for promoting absorption of the nutrients, and effective components for reducing fat, lowering blood sugar, lowering blood pressure and lowering blood fat, and specifically comprises: broccoli powder or carrot powder, black fungus powder, pleurotus eryngii powder, oyster powder, vitamin C, vitamin B2, heme iron, hericium erinaceus cell wall-broken ultrafine powder, composite fermented powder of Chenopodium quinoa and chickpea, olive kernel peptide powder, and composite fermented powder of Sacha Inchikernel and linseed, wherein the pleurotus eryngii powder is dried in the sun. The comprehensive nutrition powder comprehensively considers interaction between various nutrients, eliminates interference of phytic acid on absorption of minerals, and can achieve effects of reducing fat, lowering blood sugar, lowering blood pressure and lowering blood fat from multiple sources and in various aspects.The preparation method can well retain nutrition of dietary ingredients in the comprehensive nutrition powder, and maximize functions of the effective ingredients in reducing fat, lowering blood sugar, lowering blood pressure and lowering blood fat.

The present invention relates to a method for biologically producing heme-iron through microorganism cultivation, and to an iron supplementing composition containing the heme-iron produced by the same. The present invention provides a method for biologically producing heme-iron through microorganism cultivation, making it possible to economically produce heme-iron or heme-iron preparations which can be safely used as an iron supplement.

A process for making hemoglobin based oxygen carrier (HBOC) containing pharmaceutical composition suitable for oral delivery and the composition formed thereby are described. There are three exemplary composition configurations which include (1) hemoglobin-loaded nanoparticles solution, (2) enteric-coated hemoglobin capsules and (3) enteric-coated hemoglobin tablets. To facilitate the bioavailability and bio-compatibility of hemoglobin, intestinal absorption enhancers are added in each of the HBOC formulations. Protective layers ensure delivery of an intact hemoglobin structure in intestinal tract without degradation in the stomach. The HBOC formulations may be used for preventive or immediate treatment of high altitude syndrome (HAS) or for treatment of hypoxic conditions including blood loss, anemia, hypoxic cancerous tissue, and other oxygen-deprivation disorders. In addition to delivering oxygen, the heme group of hemoglobin from HBOC formulations can provide heme iron to the human body to aid in the production of more red blood cells.

A composition comprising heme iron and / or heme iron polypeptide in combination with ionic iron(s) and / or chelated iron(s). Administration of effective dosages of the present composition provides a method for treating and / or preventing iron deficiency anemia, and the physiological, biochemical, morphological, and behavioral manifestations symptomatic of same.

The invention discloses a method for preparing high-ferric content ferroheme polypeptide composite with pepsin two-hydrolysis method, which is a method for preparing ferroheme polypeptide with twice enzyme hydrolysis of blood, and polypeptide generated by hydrolyzed protein wraps ferroheme to form frroheme polypeptide composite; adopting twice protease hydrolysis of hemoglobin, ferroheme combineswith peptide generated by proteolysis to generate composite (ferroheme polypeptide) of ferroheme and polypeptide, the combination of the composite is very firm, and is not easy to separate, the enzyme hydrolysis can realize the further dissociation of peptide in ferroheme polypeptide, the ferroheme content in ferroheme polypeptide is improved, the polypeptide content thereof is reduced, and heme iron content is high; since ferroheme has the combination and coverage of hydrophilic polypeptide, the composite has a certain hydrophilcity, is easily solute in acid solution such as gastric acid, acetic acid and the like and is easy to digest and absorb.

The invention discloses a composite preparation of extract of bamboo shoots which is used for improving anaemia and a preparation method thereof. The composite preparation is made from the extract of bamboo shoots, iron supplement and other accessory ingredients, wherein, the extract of bamboo shoots is solid, extract liquid or dry powder which is extracted from fresh or dried bamboo shoots by water extraction and alcohol extraction; the iron supplement is ferriporphyrin or heme iron. By adopting the design, the extract of bamboo shoots in the composite preparation of the invention comprising rich glucose, protein and multi elements can stimulate hematopoiesis and expand blood volume and the iron composite preparation thereof has better promotion effect on the recovery of blood loss anemia. By adopting the preparation method of the invention to prepare the extract of bamboo shoot, the process is simple and practical and the various beneficial components in bamboo shoots can be well kept, thus being applicable to commercial production.

The invention relates to an iron supplement, which is an iron liposome made by ethanol injection. The iron liposome comprises (by weigh parts) heme iron and / or inorganic iron 0.1-200, cholesterol 1-10 and lecithin 10-100; and is prepared by dispersing lecithin and cholesterol ethanol solution into a PBS-containing iron solution under specific conditions. The inventive iron liposome has no toxicity and immunogenicity, has targeting property, and can be used as a drug carrier. The iron liposome can be used in clinics for reducing drug dosage, improving absorption efficiency, reducing toxicity, remarkably improving solubility and stability of the heme iron, and improving bioavailability. The inventive preparation method can form stable liposome with high entrapment efficiency, can effectively save liposome preparation time and simplify preparation process, and has the advantages relatively low requirements on process conditions, easy control, and simple operation.

The present invention relates to a method for biologically producing heme-iron through microorganism cultivation, and to an iron supplementing composition containing the heme-iron produced by the same. The present invention provides a method for biologically producing heme-iron through microorganism cultivation, making it possible to economically produce heme-iron or heme-iron preparations which can be safely used as an iron supplement.

An object of the present invention is to provide a method for analyzing hemoglobins which can accurately separate hemoglobins in a short time by liquid chromatography.The present invention provides a method for analyzing hemoglobins by liquid chromatography which includes pre-treating a sample with an oxidant and a binder for trivalent heme iron.

The invention provides a high affinity heme-binding agent, which can be provided in the form of a pharmaceutical composition that includes, optionally, a pharmaceutically acceptable carrier. The heme-binding agent can be used in a method of facilitating heme-iron export from a cell. The method comprises contacting a cell with a high affinity heme-binding agent. Also provided is a method of treating a disorder associated with excess iron in cells in a subject. The method comprises administering to the subject an effective amount of the composition of the invention. The subject is typically a mammal, most typically a human or veterinary subject.

The present invention relates to heme iron not derived from porcine blood and a method of preparing the same, and more particularly to a method of biologically preparing heme iron not derived from porcine blood, a method of preparing a salt thereof, and an iron supplement containing the salt thus prepared as an active ingredient.

A process for making hemoglobin based oxygen carrier (HBOC) containing pharmaceutical composition suitable for oral delivery and the composition formed thereby are described. There are three exemplary composition configurations which include (1) hemoglobin-loaded nanoparticles solution, (2) enteric-coated hemoglobin capsules and (3) enteric-coated hemoglobin tablets. To facilitate the bioavailability and bio-compatibility of hemoglobin, intestinal absorption enhancers are added in each of the HBOC formulations. Protective layers ensure delivery of an intact hemoglobin structure in intestinal tract without degradation in the stomach. The HBOC formulations may be used for preventive or immediate treatment of high altitude syndrome (HAS) or for treatment of hypoxic conditions including blood loss, anemia, hypoxic cancerous tissue, and other oxygen-deprivation disorders. In addition to delivering oxygen, the heme group of hemoglobin from HBOC formulations can provide heme iron to the human body to aid in the production of more red blood cells.

The present invention relates to heme iron not derived from porcine blood and a method for preparing same, and more specifically, to a method for preparing heme iron not derived from porcine blood through biological preparation steps, a method for preparing salts thereof, and an iron supplement containing the salt prepared thereby as an active ingredient.

The invention discloses a method for improving the egg quality. Laying hens are fed by a basal feed added with a special feed; the special feed comprises natural haematococcus pluvialis, heme iron andcalcium lactate; the weight of natural haematococcus pluvialis is 1% of the total weight of the basal feed; the weight of heme iron is 0.1% of the total weight of the basal feed; the weight of calcium lactate is 0.1% of the total weight of the basal feed; the natural haematococcus pluvialis contains 1-5% of natural astaxanthin; and the laying hens are subjected to immune treatment. The natural haematococcus pluvialis containing the natural astaxanthin is added into the traditional laying hen feed; therefore, the physical quality and the eating desire of the laying hens are increased; the absorption rate of feed nutrients and the biotransformation efficiency of astaxanthin are increased; the feed-egg conversion rate of laying lens special for astaxanthin eggs is up to 0.2:1; heme iron andcalcium lactate are added into the traditional laying hen feed; therefore, the content of iron and calcium in eggs are increased by above 2 times; due to immune of chickens, the content of IgY in theeggs is increased, and above 100 times of the original content; and, due to the immunological enhancement of astaxanthin, the content of immune globulin is further increased.

The invention discloses a pabular health tea electuary for promoting lead excretion, which belongs to the field of nutritious foods and has good effect and rapid effect. The pabular health tea electuary is made from the raw materials such as cordyceps sinensis, dried malt, L-zinc lactate, ligusticum wallichii, heme iron, active calcium and the like, has the functions of supporting body resistance, reinforcing qi, nourishing blood, promoting blood circulation, removing blood stasis and excreting lead, and has the advantages of good effect and rapid effect.

The invention relates to the technical field of preparation of silicon micro-powder and particularly relates to a preparation method of high-dispersibility silicon dioxide micro-powder. The preparation method comprises the following steps: firstly, taking animal blood as a raw material, and performing enzymolysis and heating to remove impure protein to obtain biomass extract rich in heme iron; reducing the heme iron to ferrous ions with hydrochloric acid to obtain protein reaction liquid rich in ferrous ions; then, precipitating parts of ferrous ions with ammonium hydroxide, performing etherification reaction with hydroxyl in the reaction liquid through an etherifying agent, and introducing a propyl sulfonate group into the reaction liquid to obtain home-made functional liquid; and addingthe home-made functional liquid to the reaction liquid of sodium silicate and hydrochloric acid to finally obtain the high-dispersibility silicon dioxide micro-powder. The prepared silicon dioxide micro-powder has excellent dispersibility, is not easy to agglomerate, is uniform in particle size and has wide application prospects.

The invention belongs to the technical field of food auxiliary materials and food auxiliary material processing, and particularly relates to an animal nutrition reinforcer which has the blood replenishing and blood activating effects and is called cerebrolysin for short. The cerebrolysin contains glycine-iron, iron methionine, ferrous fumarate, ferrous sulfate, Vb12, folic acid, hemin, cobalt sulfate and the like. By means of contained heme iron mainly obtained from animal-derived components and non-heme iron obtained from plant components and cofactors, iron supplementation is more balanced and stable, easier to absorb and use and not likely to be affected by external factors.

The invention relates to a spirulina health care product, which pertains to the technique improvement of processing spirulina by an industrial method. Spirulina is an ideal pure natural healthy food with biological activity, but after a series of complex industrial processes (such as drying in high temperature and pressing into tablet), lots of active nutrient substances in fresh spirulina are inactivated, lost and diluted. The product prepared by the invention is provided with and supplements the nutrient substances in spirulina that are lost in a series of industrial processes. The components of the product comprise vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin C, calcium hydrogen phosphate, biological yeast zinc, biological heme iron, spirulina, starch, folic acid, SOD active factors, vitamin B12, bismuth potassium citrate and magnesium sulphate. The product is an edible health care product.

The present invention relates to heme iron not derived from porcine blood and a method of preparing the same, and more particularly to a method of biologically preparing heme iron not derived from porcine blood, a method of preparing a salt thereof, and an iron supplement containing the salt thus prepared as an active ingredient.

A process for making hemoglobin based oxygen carrier (HBOC) containing pharmaceutical composition suitable for oral delivery and the composition formed thereby are described. There are three exemplary composition configurations which include (1) hemoglobin-loaded nanoparticles solution, (2) enteric-coated hemoglobin capsules and (3) enteric-coated hemoglobin tablets. To facilitate the bioavailability and bio-compatibility of hemoglobin, intestinal absorption enhancers are added in each of the HBOC formulations. Protective layers ensure delivery of an intact hemoglobin structure in intestinal tract without degradation in the stomach. The HBOC formulations may be used for preventive or immediate treatment of high altitude syndrome (HAS) or for treatment of hypoxic conditions including blood loss, anemia, hypoxic cancerous tissue, and other oxygen-deprivation disorders. In addition to delivering oxygen, the heme group of hemoglobin from HBOC formulations can provide heme iron to the human body to aid in the production of more red blood cells. The presently claimed invention provides improved hemoglobin formulations for forming nanoparticles with improved properties via polyelectrolyte complexation and for lyophilization to form mixture powder or particles with improved properties.

The invention discloses a blood protein polypeptide rich in heme iron and a preparation method thereof, and belongs to the technical field of blood protein polypeptides, the blood protein polypeptide contains heme iron, and is obtained by firstly adding an anticoagulant into animal fresh blood, then centrifuging, discarding plasma, collecting red blood cells, breaking walls, heating, performing enzymolysis, performing ultrafiltration, concentrating and drying. The blood protein polypeptide is rich in heme iron, can be directly absorbed by intestinal mucosa cells compared with a traditional iron supplementing agent, and does not easily generate any digestive tract stimulation symptom; during preparation, a high-pressure homogenizer is adopted, so that the efficiency is improved, and the protein content is increased; and further heating for 30 minutes at 50 DEG C under a dark condition to remove denatured impure proteins, so that the content of hemoglobin is up to 90% or above. While the peptide is generated, the heme iron is not completely separated from the protection of the peptide and is continuously kept in a divalent water-soluble state. The gastrointestinal tract discomfort phenomena such as nausea and vomiting after the conventional iron agent product is taken are avoided, and the trouble of anemia people is solved.

The invention discloses a composite vitamin-containing composition, which is prepared from a vitamin b group, vitamin b3 derivative nicotinamide mononucleotide, vitamin c, sesami nigrum semen raw powder, mori fructus raw powder, fructus lycii polypeptide component, sea cucumber polypeptide and heme iron. The composite vitamin-containing composition also comprises food additives of microcrystalline cellulose and pvp-k30, and has the effects of alleviating alopecia, relieving fatigue, refreshing mind and resisting aging.

The invention discloses a hematopoietic nutrient feed additive, a preparation method and an application thereof. The hematopoietic nutritional feed additive contains the following active components in parts by mass: 10-30 parts of a hematopoietic regulating traditional Chinese medicine composition, 40-60 parts of a hematopoietic nutritional composition, and 10-50 parts of a hematopoietic nutritional strengthening composition. The hematopoietic nutrient feed additive of the present invention adopts scientific formula, overall layout, optimized ratio, and optimized raw materials, so that the synergistic effect among the various components, replenishing qi and tonifying deficiency, nourishing both qi and blood, and regulating blood cells by activating the bone marrow hematopoietic function of the body Differentiate and proliferate, promote the conversion of non-heme iron into heme iron with biological value, improve intracellular iron utilization efficiency, increase hemoglobin level, prevent animal anemia, and improve animal production performance.

An iron-containing soy is prepared through proportioning raw materials, steaming, inoculation, preparing yeast, fermenting, filtering, adding the enzymolyzed animal's heme liquid, homogenizing, emulsifying, filtering, and sterilization. Its advantages are rich nutrients including heme iron, ammino acids and short peptide and low cost.

The invention provides food blood nourishing tea electuary for treating alimentary anemia and belongs to the field of nutritious foods. The food blood nourishing tea electuary has good effect and can take effect quickly. The food blood nourishing tea electuary provided by the invention is prepared from lance asiabell root, angelica, heme iron, glutathione, sea cucumber and the like and has the functions of supporting body resistance, reinforcing qi, nourishing blood, promoting blood circulation to remove blood stasis and preventing anemia.

The invention belongs to the technical field of food processing, and discloses nutritional pig blood tofu and a preparation method thereof, and the preparation method comprises the following steps: uniformly dispersing cellulose ether in water, then uniformly mixing the cellulose ether with anticoagulant pig blood, adding a coagulant, standing for 5-15 minutes for solidification, and then freezing at-20 DEG C for 12-24 hours to obtain the pig blood tofu, wherein the anticoagulant pig blood is prepared by the following steps: uniformly dispersing an anticoagulant in fresh pig blood, filtering, and carrying out ultrasonic treatment on the filtrate for 2-3 minutes under the ultrasonic power of 200-500w, so as to obtain the anticoagulant pig blood. The pig blood tofu is prepared by adopting an ultrasonic technology and adding cellulose ether, so that erythrocyte walls in the pig blood tofu are broken, heme iron is released, the content of free heme iron which can be utilized by a human body is increased, and the multi-nutrition functional blood tofu which is high in iron utilization rate and has potential physiological functions of resisting oxidation, reducing blood sugar, reducing blood fat and the like is formed; the nutritional value of the pig blood bean curd is greatly improved.

The invention discloses a hematopoietic nutrition feed additive and a preparation method and application thereof. The hematopoietic nutrition feed additive is prepared from the following active components in parts by mass: 10 to 30 parts of hematopoietic regulation traditional Chinese medicine composition, 40 to 60 parts of hematopoietic nutrition composition, and 10 to 50 parts of hematopoietic nutrition enhancing composition. The hematopoietic nutrition feed additive has the advantages that by adopting the scientific formula, the integral layout, the proportional optimizing and the raw material optimizing, the synergistic function is realized between the components, the effects of tonifying Qi and tonifying deficiency, and tonifying Qi and blood are realized; and by activating the hematopoietic function of bone marrow of a human body, the differentiation and proliferation of blood cells are regulated, the non-heme iron is promoted to be converted into heme iron with biological value, the utilization efficiency of iron in cells is improved, the level of hemoglobin is improved, the anemia of animals is prevented, and the production property of animals is improved.

The invention provides a cowpea heme iron-binding protein as well as a preparation method and application thereof, and relates to the technical field of pesticide residue detection. The method uses cowpea cowpea seeds which have strong heat resistance, adapt to various conditions, and can grow well in different environments as raw materials to extract a cowpea crude enzyme liquid, the extracted liquid is further separated and purified, and the method has the advantages of a large yield and wide sources. The sensitivity of the cowpea heme iron-binding protein to pesticides chlorpyrifos and carbofuran is studied by colorimetry and a fluorescence method; and at the same time, the sensitivity detection of pesticide dichlorvos is carried out by Native-PAGE, results find that the cowpea heme iron-binding protein has better sensitivity to the above pesticides, so that the cowpea heme iron-binding protein has a great advantage as an alternative enzyme source for rapid detection of pesticide residues by enzyme inhibition.

The invention discloses a heme iron polypeptide composition and a preparation method thereof. Polypeptides, polyphenols, minced meat, hemoglobin, an antioxidant, oligosaccharides, radix puerariae powder, coix seed powder, wheat germ powder and purple rice flour are mixed, the mixture is subjected to secondary enzymolysis through trypsin, and the heme iron polypeptide composition is obtained through filtration and freeze drying. Compared with the prior art, the polypeptide composition disclosed by the invention has the beneficial effects that the polypeptide composition is formed by utilizing natural properties of polypeptide and ferrous heme, so that the iron content is increased, the polypeptide composition can be stored for a long time without deterioration, and the polypeptide composition also contains rich vitamins and can promote metabolism of children and improve immunity.

The invention provides a high affinity heme-binding agent, which can be provided in the form of a pharmaceutical composition that includes, optionally, a pharmaceutically acceptable carrier. The heme-binding agent can be used in a method of facilitating heme-iron export from a cell. The method comprises contacting a cell with a high affinity heme-binding agent. Also provided is a method of treating a disorder associated with excess iron in cells in a subject. The method comprises administering to the subject an effective amount of the composition of the invention. The subject is typically a mammal, most typically a human or veterinary subject.