52 results about "Fumarate Esters" patented technology

Ceramic materials operable to repair a defect in bone of a human or animal subject comprising a porous ceramic scaffold having a bioresorbable coating, and a carrier comprising denatured demineralized bone. The ceramic may contain a material selected from the group consisting of hydroxyapatite, tricalcium phosphate, calcium phosphates, calcium carbonates, calcium sulfates, and combinations thereof. The compositions may also contain a bone material selected from the group consisting of: bone powder, bone chips, bone shavings, and combinations thereof. The bioresorbable coating may be, for example, demineralized bone matrix, gelatin, collagen, hyaluronic acid, chitosan, polyglycolic acid, polylactic acid, polypropylenefumarate, polyethylene glycol, or mixtures thereof.

Devices for use in the regeneration or repair of body tissue (such as nerves) comprise a multi-lumen scaffold and, optionally, an outer sheath. The tissue guidance conduits are preferably formed of biocompatible, biodegradable charged polymer hydrogels, particularly charged oligo-(polyethylene glycol)fumarate hydrogels. The outer sheath is formed of a stronger material than the scaffold and preferably comprises a region at each end for suturing the device in place. Methods for making tissue guidance conduits and for repairing tissue are also described.

A polymerizable polymeric photoinitiator according to Formula (I):wherein:PL represents an n+m+p-functional polymeric core;n and m independently represent an integer from 1 to 30;p represents an integer from 0 to 10;o is 0 or 1;INI represents a group selected from the group consisting of a benzophenone, a thioxanthone, a carbazole, a anthraquinone, a camphor quinone, an α-hydroxyalkylphenone, an α-aminoalkylphenone, an acylphosphine oxide, a bisacyl phosphine oxide, an acylphosphine sulfide, a phenyl glyoxalate, a benzoin ether, a benzyl ketal, an α-dialkoxyacetophenone, a carbazolyl-O-acyl-oxime, an α-haloarylketone and an α-haloaryl sulfone;L3 and L4 represent a substituted or unsubstituted divalent linking group comprising 1 to 14 carbon atoms;A represents a radically polymerizable functional group selected from the group consisting of an acrylate, a methacrylate, a styrene, an acryl amide, a methacryl amide, a maleate, a fumarate, an itaconate, an vinyl ether, an allyl ether, an allyl ester, a maleimide, a vinyl nitrile and a vinyl ester; andR4 represents a substituted or unsubstituted alkyl group.Radiation curable compositions containing the polymerizable polymeric photoinitiator and methods for preparing the polymerizable polymeric photoinitiator are also disclosed.

Synthesis of polyaspartic acid ester polyether ammonium containing secondary amine is carried out by taking arylamine compound as active catalyst and Micro-addition reacting for polyether ammonium and maleate or fumarate ester to obtain final product. It has shorter reactive time and delays polyurea coating gel time.

A method of making a copolymer composition containing a copolymer, which includes the steps of (a) providing a donor monomer composition that includes an isobutylene type monomer; (b) mixing the donor monomer composition with an ethylenically unsaturated monomer composition that includes one or more ethylenically unsaturated acceptor monomers, and is substantially free of maleate type monomers and fumarate type monomers, and (c) polymerizing the mixture resulting from step (b) in the presence of a free radical polymerization initiator. The polymerization is carried out in the substantial absence of Lewis acids and / or transition metals. The isobutylene type monomer is present at a molar excess of at least 10 mol % based on the molar concentration of monomers in the ethylenically unsaturated monomer composition. The ethylenically unsaturated acceptor monomers are present in an amount of at least 15 mol % of the total monomer composition.

The invention relates to a biodegradable unsaturated polyphosphate ester containing phosphate ester and fumarate ester bonds and discloses a preparation method of the polyphosphate ester and a method for the application of the polyphosphate ester as a medical sustained release preparation for injecting into a treated part and as a hard tissue repair and filling material. The mixture composed of the polyphosphate ester, a cross-linking vinyl monomer, a free radical thermal initiator or photo initiator being capable of initiating or assist in initiating covalent cross-linking reaction and biologically active drugs has excellent medical sustained release effect and no toxic side effects. As a material for repairing the defects of osseous tissue, the biodegradable unsaturated polyphosphate ester can stimulate the formation of new bones; and the material can also be degraded gradually and finally be substituted by a new bone completely. The biodegradable unsaturated polyphosphate ester has outstanding biocompatibility and no obvious inflammation reactions and teratogenesis.

The invention belongs to the field of a macromolecule compound material and discloses a chitosan chemically-modified functional derivative O-fumarate ester-N-chitosan quaternary ammonium salt and a preparation method and application thereof. The preparation method of the O-fumarate ester-N-chitosan quaternary ammonium salt comprises the following steps: carrying out microwave reaction between chitosan and 2,3-epoxypropyl trimethyl ammonium chloride to prepare an N-chitosan quaternary ammonium salt; reacting fumaryl chloride prepared from a fumaric acid and thionyl chloride with N-chitosan quaternary ammonium salt to prepare the O-fumarate ester-N-chitosan quaternary ammonium salt. The O-fumarate ester-N-chitosan quaternary ammonium salt not only has good water solubility, and is greatly improved in term of the antibacterial property as compared with the chitosan; the O-fumarate ester-N-chitosan quaternary ammonium salt can be applied to a plurality of application fields such as antibacterial materials, daily chemical products, industrial wastewater and the like.

Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral pharmaceutical compositions comprising controlled release matrices comprising fumarate esters are described.

A copolymer containing vinyl-3,4-cyclohexanediol and at least one monomer selected from acrylic acid, methacrylic acid, alkyl acrylate, alkyl methacrylate, styrene, acrylonitrile, butadiene, isoprene, vinyl acetate, maleic anhydride, ethylene, vinyl chloride, vinylidene dichloride, methyl styrene, vinyl toluene, acrylic and methacrylic acid, vinyl acetate, maleic anhydride, fumarate esters, maleate esters, vinylidene difluoride, vinyl fluoride, acrylic or methacrylic esters of the formula (I) H2C=CHCOOR or H2C=CCH3COOR(I) where R is a aromatic or aliphatic hydrocarbon group containing 20 or fewer carbons and optionally containing oxygen, sulfur, or phosphorous, and mixtures thereof. A resin composition containing vinyl-3,4-cyclohexanediol, at least one carboxylic acid or ester thereof or anhydride, and optionally a polyol or diol other than vinyl-3,4-cyclohexanediol. A process for preparing this resin composition which involves mixing in a nitrogen atmosphere vinyl-3,4-cyclohexanediol, at least one carboxylic acid or ester thereof or anhydride, and optionally a polyol or diol other than vinyl-3,4-cyclohexanediol to form a mixture and heating the mixture to about 180 DEG -290 DEG C. until the desired level of polymerization is reached to form the resin composition. A copolymer containing the vinyl-3,4-cyclohexanediol containing resin composition and at least one monomer selected from acrylic acid, methacrylic acid, alkyl acrylate, alkyl methacrylate, styrene, acrylonitrile, butadiene, isoprene, vinyl acetate, maleic anhydride, ethylene or mixtures thereof.

A polymerisable photoinitiator according to Formula (I):wherein:R1 and R2 are independently selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group, a substituted or unsubstituted aryl or heteroaryl group, a halogen, an ether group, a thioether group, an aldehyde group, a ketone group, an ester group, an amide group, an amine and a nitro group;R1 and R2 may represent the necessary atoms to form a five to eight membered ring;L represents an n+m-valent linking group comprising 1 to 30 carbon atoms;A represents a radically polymerizable group selected from the group consisting of an acrylate group, a methacrylate group, a styrene group, an acryl amide group, a methacryl amide group, a maleate group, a fumarate group, an itaconate group, a vinyl ether group, an allyl ether group, a vinyl ester group and an allyl ester group; andn and m independently represent an integer from 1 to 5.

Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethyl-lene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.

The invention relates to a polymer used in lubricating oil pour point depressing, a lubricating oil pour point depressant, and a preparation method thereof. The polymer provided by the invention is a random copolymer of fumarate, vinyl acetate and allyl carbamate. The polymer has a certain dispersion effect, and a good pour point depressing effect.

A polymerisable photoinitiator according to Formula (I):wherein:R1 and R2 are independently selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group, a substituted or unsubstituted aryl or heteroaryl group, a halogen, an ether group, a thioether group, an aldehyde group, a ketone group, an ester group, an amide group, an amine and a nitro group;R1 and R2 may represent the necessary atoms to form a five to eight membered ring;L represents an n+m-valent linking group comprising 1 to 30 carbon atoms;A represents a radically polymerizable group selected from the group consisting of an acrylate group, a methacrylate group, a styrene group, an acryl amide group, a methacryl amide group, a maleate group, a fumarate group, an itaconate group, a vinyl ether group, an allyl ether group, a vinyl ester group and an allyl ester group; andn and m independently represent an integer from 1 to 5.

The invention relates to an engine oil composition, which takes the total weight of the engine oil composition as the reference. The engine oil composition is prepared from the following components in percentage by weight: 0.1 to 0.4 percent of a pour point depressant, 1.5 to 8.0 percent of a viscosity index improver, 1.79 to 3.93 percent of a clearing agent, 0.64 to 3.07 percent of a dispersing agent, 1.04 to 3.67 percent of an antioxidant, 0.01 to 5 percent of a friction reducing agent, 0.3 to 1.5 percent of zinc dialkyl dithiophosphate and the balance of neutral base oil, the pour point depressant comprises a vinyl acetate-fumarate pour point depressant; the vinyl acetate-fumarate pour point depressant is prepared from the following components in parts by weight: 0.4 to 0.6 part of octadecyl fumarate, 0.8 to 1.2 parts of dodecanol fumarate, 0.8 to 1.2 parts of tetradecyl fumarate, 0.8 to 1.2 parts of hexadecyl fumarate and 0.8 to 1.2 parts of octadecyl fumarate. The engine oil composition has good emulsification retention ability, wear resistance and detergency and dispersibility.

A copolymer composition that includes a copolymer comprised of at least 30 mol % of residues having the following alternating residues from a donor monomer and from an acceptor monomer. The copolymer contains at least 15 mol % of an isobutylene type donor monomer and at least 15 mol % of an acrylic monomer as an acceptor monomer. The copolymer is substantially free of maleate or fumarate monomer segments and the copolymer composition is substantially free of Lewis acids and transition metals. Also disclosed is a thermosetting composition that includes a reactant comprising functional groups, a crosslinking agent having at least two functional groups that are reactive with the functional groups first reactant, and a copolymer flow control agent that includes the copolymer composition as well as substrates coated with the thermosetting composition.

The present invention relates to a hardenable silicone composition including an irradiation-activated system for temporarily inhibiting the hydrosilylation reaction. Said system includes at least one inhibitor selected from among alpha-acetylenic alcohols, alpha-alpha'-acetylenic diesters, conjugated ene-yne compounds, alpha-acetylenic ketones, acrylonitriles, maleates, fumarates, the mixture thereof, at least one photoinitiator, and tris(trimethylsilyl)silane (TTMSS). The invention also relates to a method for preparing a silicone coating and hard elastomer materials provided comprising said silicone composition.

The present invention relates to an LC-MS detection method for detecting 9-propenyl adenine. The technical points include the following steps: (1) first determine the chromatographic conditions through the chromatographic column, column temperature and mobile phase; (2) the test sample and the preparation of the reference substance solution; (3) the assay method adopts precise measurement of the reference substance solution and the test solution respectively, injects into the chromatograph, records the chromatogram, and calculates with the peak area according to the external standard method; the test substance does not interfere with 9‑ The detection of propenyl adenine further realizes the present invention. The present invention has the advantages of establishing a LC-MS detection method for determining 9-propenyl adenine in tenofovir disoproxil fumarate. The detection method can accurately detect the content of 9-propenyl adenine; the method has high sensitivity and strong specificity; it can effectively detect the content of 9-propenyl adenine to control the quality of tenofovir disoproxil fumarate.

The invention relates to a preparation method of antiseptic mono-benzyl-methyl fumarate, which belongs to the technical field of food antiseptic, and comprises the following steps that: (1) preparing and isomerizating mono-benzyl-methyl fumarate: isomerized catalyst is added into maleic anhydride and phenylcarbinol after being reacted for a period of time under the reaction temperature, and the maleic anhydride and the penylcarbinol are isomerizated for a period of time to obtain the mono-benzyl fumarate under an isomerization temperature. (2) The mono-benzyl fumarate, methanol and catalyst with certain quantity are sequentially added into a flask to obtain the pure mono-benzyl-methly fumarate. The method adopts maleic anhydride, methanol and phenylcarbinol as raw materials to prepare novel fumarate - mono-benzyl-methyl fumarate, so the obtained compound simultaneously has a good bacteriostatic function and a good oxidation resistant function, and a novel though can be provided to develop a novel multifunctional food additive. The product is developed to a series of food additives having multiple functions.

A radiation-curable composition having a reduced surface energy and including a reactive dye containing at least one radiation-curable substituent and at least one fluorine-containing substituent. The reactive dye may include any anthraquinone, methine, azo, azine, or xanthene dye adapted to contain at least one radiation-curable substituent and at least one fluorine-containing substituent. The radiation-curable substituent may include (meth)acrylate, styrene, vinyl ether, vinyl ester, N-substituted acrylamide, N-vinyl amide, maleate ester, and fumarate ester.

Suggested are oil-based agrochemical compositions with increased viscosity, comprising (a) biocides, (b) hydrophobic carriers, and (c) polymers selected from the group consisting of poly(meth)acrylates, polymaleates and polyfumarates.

The invention relates to an antiviral drug tenofovir disoproxil fumarate and a novel preparation method thereof, belonging to the field of medicines. Content of related substances in the tenofovir disoproxil fumarate, especially content of impurity K is effectively lowered by taking toluenesulfonyloxy diethyl methylphosphonate as a starting material through hydrolysis, condensation and salifying. Moreover, the preparation method is gentle in reaction condition, low in production cost, simple and convenient to operate, and suitable for large-scale industrial production.

Provided are a resin composition characterized by containing 30-99 mass% of a cellulose resin represented by general formula (1) below, and 70-1 mass% of a fumaric acid ester polymer containing 30 mol% or more of fumaric acid residue units represented by general formula (2) below; an optical compensation film employing the same; and a production method for an optical compensation film. (1) (2) (In the formulas, R1-R3 represent C1-12 substituent groups, and R4 and R5 represent C1-12 alkyl groups.)

The invention discloses a low-fading-tendency crease-proof antirust paint. The invention is characterized in that the antirust paint is prepared from the following raw materials in parts by weight: 3-5 parts of fine sheet glass, 2-3 parts of zirconia, 4-6 parts of titanium white, 3-4 parts of potassium silicate, 1-2 parts of triallyl isocyanurate, 1-2 parts of fumarate, 1-2 parts of 2,6-di-tert-butyl-para-cresol, 4-6 parts of aluminum tripolyphosphate, 2-3 parts of amine benzoate, 12-14 parts of melamine formaldehyde resin, 32-35 parts of E-44 epoxy resin, 1-2 parts of zinc cyanurate, 14-17 parts of amino resin, 10-13 parts of xylene, 10-15 parts of ethyl formate and 4-7 parts of assistant. The paint film has the advantages of high adhesive force, high hardness, high smoothness, low fading tendency, crease proofness and rust prevention; and the added assistant has the sound insulation function, and can reduce the injury of noise to the human body. The paint has the advantages of high cost performance and favorable decoration performance, and is worthy of popularization.

The present invention provides a polymorph of a CDK9 inhibitor and a preparation method for the polymorph and use thereof. Specifically, disclosed are 4-(((4-(5-chloro-2-(((1R,4r)-4-(((R)-1-methoxypropyl-2-yl)amino)cyclohexyl)amino)pyridine-4-yl)thiazole-2-yl)amino)methyl)tetrahydro-2H-pyrano-4-methylnitrile maleate or fumarate or polymorphs thereof and applications thereof. In addition, also disclosed are a pharmaceutical composition containing the substance and an application of the pharmaceutical composition.

The invention belongs to the drug technology field, and particularly relates to a preparation method of a compound 9-[[(R)-2-[[diethoxy]phosphinyl] methoxy]propyl]adenine (I). The compound can be used for preparing an intermediate of tenofovir disoproxil fumarate (a chemical name: 9-[(R)-2-[[bis[[(isopropoxycarbonyl)oxy]methoxy]phosphinyl]methoxy]propyl]adenine fumarate).

The present invention relates to a polyurea coating composition comprising (A) a polyisocyanate; (B) a polyaspartic ester; and (C) an aspartic ester. The polyaspartic ester (B) is represented by the structure (I), where Z = a cycloalkyl, alkyl or aryl group, R1, R2 = alkyl groups containing 1-10 carbon atoms; and n = 2-4. The aspartic ester (C) is derived from a secondary heterocyclic amine in a 3-7 membered ring compound bearing at least one secondary amine functionality. This invention also relates to use of a polyurea coating composition comprising (A)-(C) for the preparation of a polyureacoating. This invention further relates to a process for preparing a polyaspartic / aspartic ester mixture in-situ by initially reacting an ester of fumaric acid or maleic acid with a polyamine and thenreacting the unreacted ester of fumaric acid or maleic acid to completion with a secondary heterocyclic amine. This method makes it possible to prepare a polyurea coating without maleic acid or fumaric acid esters thereby providing a safer and more environmentally friendly product.