71 results about "Forsythoside A" patented technology

The present invention relates to process of purifying forsythia extract to obtain forsythoside A. Specifically, forsythia phenols are further purified to obtain high purity forsythoside A in high extracting efficiency.

The present invention relates to the applications of forsythia ester glycoside in preparing a sensitivity-enhancing and toxicity-reducing medicine in resisting tumor chemotherapy or AIDS. The present invention is a medicinal compound prepared by forsythia ester glycoside and pharmaceutical carrier and / or excipient. The prepared medicinal compound is used for enhancing sensitivity and reducing toxicity in resisting tumor chemotherapy or AIDS, which has the advantages of good curing effect, less side effects and increasing the living quality of patients.

The invention relates to the technical field of drug quality control and in particular relates to a quality control reference substance for antelope's horn tablets for common cold. The retention time of chlorogenic acid, liquiritin, rhamnosylvitexin, isorhamnetin-3-O-neohesperidin, forsythoside A, forsythin and arctiin is respectively 9.954, 38.591, 39.767, 43.191, 43.807, 60.715 and 62.065 minutes, the separation degree of each component from the adjacent peak is higher than 1.5, and the numbers of theoretical plates are respectively 10940, 49640, 22085, 257778, 205587, 376909 and 499904. According to the reference substance, multiple Chinese patent medicines and traditional Chinese medicinal materials can be qualitatively, semi-quantitatively and quantitatively researched, and the reference substance has the characteristics of convenience, rapidness, accuracy and high adaptability and has high application potentials.

The invention discloses a preparation method for forsythoside A. The preparation method for the forsythoside A comprises the following steps of: (1) immersing raw material medicament in acid, and extracting; (2) separating by using resin; (3) separating by using polyamide; (4) separating by using resin; (5) purifying by using reverse phase silica gel; and (6) purifying by using dextrangel. According to the method, an alcohol-water system is used for extraction and separation, and resin materials used in the process are recycled, so the production cost is reduced. By the extraction method of the preparation method for the forsythoside A, the content of the final product forsythoside A is up to 90 to 95 percent; therefore, the process is simple and efficient, and is suitable for industrial production.

The invention provides a forsythoside A and a preparation method thereof, and belongs to the field of medicines. In the preparation method, fruits of a traditional Chinese medicine of fructus forsythia are taken as raw materials, and are extracted, separated, crystallized, recrystallized and the like, and the high-content forsythoside A with good effect of clearing heat and releasing toxin and capacity of preventing acute or chronic hepatic injury is prepared; and a high performance liquid chromatography is adopted for measuring, and the content range is 60-99.8 percent. The modern separation and purification technology for traditional Chinese medicines is adopted, so the preparation method is novel in process, simple and convenient to operate and suitable for industrial production, and has high practicability.

The subject invention provides a novel and advantageous method for preventing and treating viral infection. Specifically exemplified herein are therapeutic uses of forsythoside A and jacaranone, compounds isolated from traditional Chinese medicinal material such as Fructus forsythiae (Lian Qiao). Also provided is use of a Yin Qiao San composition for preventing and treating viral infection.

The invention belongs to the field of medicines and health-care products, and particularly relates to application of a phenolic glycoside mixture in preparation of medicines or health-care products for preventing and treating hepatic fibrosis, in particular to a phenolic glycoside mixture of a total phenolic glycoside extract of lamiophlomis rotata, and an extraction method of the total phenolic glycoside extract of lamiophlomis rotata. The total phenolic glycoside extract of the lamiophlomis rotata comprises eight symbolic components, namely verbascoside, forsythiaside B, 4-hydroxybenzoic acid, icariin H1, Decaffeoylverbascoside, cosmosiin, luteolin and apigenin, has an anti-hepatic fibrosis effect, and can be used for preparing a medicine for preventing and treating hepatic fibrosis or a health-care product for assisting in treating CCl4 liver injury. According to the extraction method of the lamiophlomis rotata total phenolic glycoside extract, the polyacrylamide gel resin is adopted, so that separation and purification of the lamiophlomis rotata total phenolic glycoside extract are smoother, and the yield is higher.

The invention discloses a method for determining the contents of seven components in lonicera and forsythia powder by adopting dual-wavelength quantitative analysis of multi-components by a single marker, which comprises the following steps of: respectively taking neochlorogenic acid, chlorogenic acid, forsythiaside A, isochlorogenic acid A, isochlorogenic acid C, forsythin and arctiin as reference substances and forsythiaside A as an internal reference substance, calculating the relative correction factors of arctiin and forsythin at 237 nm, calculating the relative correction factors of neochlorogenic acid, chlorogenic acid, isochlorogenic acid A and isochlorogenic acid C at 327 nm, taking a forsythiaside A reference substance solution and a test solution, injecting the solutions into a high performance liquid chromatograph, and calculating the contents of seven components including forsythiaside A, forsythin, arctiin, neochlorogenic acid, chlorogenic acid, isochlorogenic acid A and isochlorogenic acid C in the lonicera and forsythia powder according to the relative correction factors. According to the invention, the same test solution is adopted to determine the contents of seven components under two absorption wavelengths, so that the detection efficiency is improved, and the detection cost is reduced.

The invention belongs to the technical field of medicine analysis and specifically relates to an establishment method for a fructus forsythiae medicine fingerprint. The method specifically is realizedby the following steps of preparing a reference substance solution, taking appropriate amount of forsythin, forsythoside A, isoforsythiaside, rutin and forsythingenin reference substances, and preparing the reference substances into the reference substance solution; preparing a test sample solution, weighing fructus forsythiae medicine powder, carrying out heating reflux extraction, taking subsequent filtrate, carrying out filtering through utilization of filter membrane, taking the subsequent filtrate as a sample solution, measuring the sample solution and a puerarin water solution, and carrying out mixing uniformly to obtain the test sample solution; and carrying out detection through adoption of a high performance liquid chromatography and establishing the fingerprint. According to themethod, high performance liquid chromatography detection is carried out on the fructus forsythiae medicine through adoption of different gradient elution, a separation effect is good; through external addition of an internal standard, the established fingerprint has a semiquantitative function, so change of components among samples can be effectively expressed, and quality of the samples can be judged relatively precisely; and quality monitoring can be carried out on the raw material fructus forsythiae medicine relatively comprehensively.

The invention provides an application of forsythia flower yellow pigment in preparing an anti-oxidative stress injury drug. The preparation step of the yellow pigment is as follows: adding dried forsythia flower powder into 95% ethanol according to a solid-liquid ratio of 1:100, performing water bath at 50 DEG C, and performing extraction by a hot reflux method; and performing suction filtration separation, repeating extraction twice, collecting the extractive liquid, performing rotary evaporation concentration, carrying out freeze drying, and collecting dry powder. The yellow pigment contains: rutin, forsythoside A, rosin, forsythin and the like. The yellow pigment can effectively eliminate ROS free radicals in caenorhabditis elegans body by up-regulating the expression of DAF-16 and SKN-1 target genes, increase the activity of antioxidant enzymes in elegans body, reduce the free radical content in the elegans body and weaken the oxidative stress damage in the elegans body by juglone,and can significantly prolong the lifespan of wild-type elegans N2 and daf-16 mutant elegans under oxidative stress, thereby increasing the resistance of elegans to oxidative stress. The yellow pigment can also be used in the preparation of functional foods resistant to oxidative stress damage.