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Forsythoside A and preparation method thereof

A technology for forsythiaside and forsythia, which is applied in the field of preparation of extracting forsythiaside A, achieves the effects of low production cost, good stability and strong practicability

Inactive Publication Date: 2011-05-11
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention overcomes the deficiencies of previous techniques and provides a method for preparing high-content forsythiaside A, which is novel in technique, easy to operate, energy-saving and environmentally friendly, and has good practicability. At present, there is no relevant patent or literature report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 50kg of forsythia medicinal material, add 350L water to heat and reflux to extract twice, each time for 2 hours, combine the extracts, filter, and cool; adjust the pH value of the filtrate to 9.0 with NaOH, add 350L ethyl acetate to extract three times, the upper layer Concentrate the extract at 65°C to a thick paste, weigh 5.4kg; add 100kg of purified water to the thick paste, heat to dissolve at 40°C, and filter; put the filtrate on a HPD-100 macroporous adsorption resin column, after the column is completed, add water After fully eluting to remove the large polar impurities, use 150L of ethanol with a concentration of 50% to elute until there is no forsythiaside A in the eluent, collect the eluate, concentrate under reduced pressure to a thick paste; add to the thick paste 2 L of methanol was heated to dissolve, cooled, and a small amount of forsythiaside A crystals with a purity of 90.2% were added as seed crystals, stirred, allowed to stand for 12 hours to crys...

Embodiment 2

[0031]Take 50kg of Forsythia medicinal material, add 350L of ethanol, heat and extract once at 75°C, extract for 2 hours, collect the extract, filter, and cool; adjust the pH value of the filtrate to 11.0 with NaOH, add 350L of n-butanol to extract twice , the upper layer extract was concentrated at 85°C to a thick paste, weighing 5.2kg; adding 100kg of purified water to the thick paste, heated to dissolve at 40°C, and filtered; the filtrate was placed on a HPD-400 macroporous adsorption resin column, and after the , after adding water to fully elute and remove the large polar impurities, use 150L of ethanol with a concentration of 20% to elute until there is no forsythiaside A in the eluent, collect the eluate, concentrate under reduced pressure to a thick paste; Add 2L of acetone, heat to dissolve, cool, add a small amount of forsythiaside A crystals with a purity of 90.5% as seed crystals, stir, let stand for crystallization for 10 h, filter, and dry to obtain 256 g of forsy...

Embodiment 3

[0034] Take 100kg of forsythia medicinal material, add 700L of water to heat and reflux for extraction once, extract for 2 hours, collect the extract, filter, and cool; adjust the pH value of the filtrate to 8.0 with sodium carbonate, add 700L of ethyl acetate to extract three times, and extract the upper layer Concentrate the liquid at 65°C to a thick paste, weighing 10.7kg; add 200kg of purified water to the thick paste, heat to dissolve at 40°C, and filter; put the filtrate on the HPD-500 macroporous adsorption resin column, after the column is completed, add water fully After removing the large polar impurities by eluting, use 300L of ethanol with a concentration of 35% to elute until there is no forsythiaside A in the eluent, collect the eluate, concentrate under reduced pressure to a thick paste; add ethanol to the thick paste 4L, heated to dissolve, cooled, added a small amount of forsythiaside A crystal with a purity of 91.4% as a seed crystal, stirred, allowed to stand...

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PUM

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Abstract

The invention provides a forsythoside A and a preparation method thereof, and belongs to the field of medicines. In the preparation method, fruits of a traditional Chinese medicine of fructus forsythia are taken as raw materials, and are extracted, separated, crystallized, recrystallized and the like, and the high-content forsythoside A with good effect of clearing heat and releasing toxin and capacity of preventing acute or chronic hepatic injury is prepared; and a high performance liquid chromatography is adopted for measuring, and the content range is 60-99.8 percent. The modern separation and purification technology for traditional Chinese medicines is adopted, so the preparation method is novel in process, simple and convenient to operate and suitable for industrial production, and has high practicability.

Description

technical field [0001] The invention relates to a preparation method for extracting forsythiaside A from medicinal plants, belonging to the field of medicine. Background technique [0002] Forsythia is one of the traditional Chinese medicines commonly used in clinical practice in China, also known as Huanghuatiao, Lianhu, Qingqiao, Luoqiao, Huangqidan, etc. Forsythia (Forsythia suspensa (Thunb.) Vahl), a plant of the genus Forsythia (Oleaceae) in the Pharmacopoeia of the People's Republic of China, is the dried fruit of Forsythia suspensa (Thunb.) Vahl, which is green when the fruit is first ripe. Harvesting is called Qingqiao, and harvesting when the fruit is ripe and the color turns yellow is called Laoqiao. [0003] Forsythia has antibacterial, cardiotonic, diuretic, antiemetic and other pharmacological effects. Forsythia is commonly used to treat acute wind-heat cold, carbuncle sore, lymph node tuberculosis, urinary tract infection and other diseases. It is Shuanghuangl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/08A61K31/7032A61P31/12
Inventor 钟慧袁红波柏强强杨永安季浩
Owner JIANGSU TIANSHENG PHARMA
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