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Olive total phenylethanoid glycoside composition and preparation and application thereof

A technology for phenethyl glucoside and tetragonus can be applied in the field of rapid preparation of phenethyl glucoside components, which can solve the problems of low yield of phenethyl glucoside compounds, difficulty in industrialization and the like, and achieves good liver protection effect and good resistance to liver fiber. to avoid the effects of poor stability

Inactive Publication Date: 2012-09-19
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this document reports the extraction and separation method of phenylethanol glycosides, the yield of its phenylethanol glycosides is extremely low, and it is obtained from 200 grams of n-butanol extract (3.6 kg of original medicinal materials), and the decaffeoyls Acteoside (cistanoside E, 31.5mg), calcellarioside B (26.5mg), acteoside (verbascoside, 82.3mg), isoverbascoside (54.3mg), alyssonoside (28.6mg)
The samples obtained in the research are all at the milligram level, which is difficult to industrialize. In addition, there are also problems in the application of toxic organic solvents in the research process

Method used

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  • Olive total phenylethanoid glycoside composition and preparation and application thereof
  • Olive total phenylethanoid glycoside composition and preparation and application thereof
  • Olive total phenylethanoid glycoside composition and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The total phenylethanol glycosides composition of Silenseed hemp in this embodiment contains the following compounds 1-6 in weight percent:

[0037] Compound 1: decaffeoyl acteoside (cistanoside E), 4.1%;

[0038] Compound 2: calcellarioside B, 6.4%;

[0039] Compound 3: verbascoside, 16.6%;

[0040] Compound 4: isoverbascoside, 28.3%;

[0041] Compound 5: forsythoside B, 25.3%;

[0042] Compound 6: alyssonoside, 2.6%;

[0043]The remainder is other low levels of phenylethanol glycosides and unavoidable impurities.

[0044] The total phenylethanol glycoside composition of Silenseed hemp in this embodiment is extracted by the following method:

[0045] 1) Take 1 kg of dried and crushed four-lens hemp of 60 mesh, add 15 kg of 60% ethanol and soak and extract at a temperature of 50°C for 10 hours, then add 60% ethanol to the residue and soak and extract at a temperature of 50°C for 8 hours , repeated the extraction three times, combined the extracts, and reclaimed et...

Embodiment 2

[0059] The total phenylethanol glycosides composition of Silenseed hemp in this embodiment contains the following compounds 1-6 in weight percent:

[0060] Compound 1: decaffeoyl acteoside (cistanoside E), 3.8%;

[0061] Compound 2: calcellarioside B, 7.2%;

[0062] Compound 3: verbascoside, 18.9%;

[0063] Compound 4: isoverbascoside, 26.8%;

[0064] Compound 5: forsythoside B, 22.3%;

[0065] Compound 6: alyssonoside, 2.2%;

[0066] The remainder is other low levels of phenylethanol glycosides and unavoidable impurities.

[0067] The total phenylethanol glycoside composition of Silenseed hemp in this embodiment is extracted by the following method:

[0068] 1) Take 3 kg of dry and crushed 60-mesh four-lens hemp, add 60 kg (20 times) of 70% ethanol and soak and extract at a temperature of 40°C for 9 hours, then add 70% ethanol to the residue at a temperature of 40°C Soak and extract for 9 hours, repeat the extraction four times, combine the extracts, recover ethanol und...

Embodiment 3

[0075] The total phenylethanol glycosides composition of Silenseed hemp in this embodiment contains the following compounds 1-6 in weight percent:

[0076] Compound 1: decaffeoyl acteoside (cistanoside E), 3.6%;

[0077] Compound 2: calcellarioside B, 6.8%;

[0078] Compound 3: verbascoside, 16.9%;

[0079] Compound 4: isoverbascoside, 25.7%;

[0080] Compound 5: forsythoside B, 22.4%;

[0081] Compound 6: alyssonoside, 3.2%;

[0082] The remainder is other low levels of phenylethanol glycosides and unavoidable impurities.

[0083] The total phenylethanol glycoside composition of Silenseed hemp in this embodiment is extracted by the following method:

[0084] 1) Take 5 kg of dried and crushed four-lens hemp of 60 meshes, add 50 kg (10 times) of 40% ethanol and soak and extract at a temperature of 60°C for 10 hours, then add 40% ethanol to the residue at a temperature of 60°C Soak and extract for 9 hours, repeat the extraction five times, combine the extracts, recover eth...

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Abstract

The invention discloses an olive total phenylethanoid glycoside composition. The olive total phenylethanoid glycoside composition comprises 6 types of particular phenylethanoid glycoside compositions which include cistanoside E, calcelarioside B, verbascoside, isoverbascoside, forsythoside B and alyssonoside and are varied from a general formula A. Pathological tests show that the olive total phenylethanoid glycoside composition in the general formula A has good anti-liver fibrosis and liver protection effects, can be used as an active ingredient of medicines for resisting liver diseases, canbe independently used or combined with proper excipients and the like, and is prepared into oral or non-oral dosage forms by conventional methods to be used for preparing medicines for treating liverdiseases.

Description

technical field [0001] The invention relates to a rapid preparation of phenylethanol glycosides components from the national medicine Tetrasporum, the extract mainly containing these compounds, their preparation method and their application in anti-hepatic fibrosis. Background technique [0002] Hepatic fibrosis is the repair response of liver tissue to chronic liver injury. It is the result of a series of complex effects of various types of cells, oxidative stress, cytokines, and growth factors. The excessive proliferation and abnormality of extracellular matrix (ECM) components Deposition is the main feature. Liver fibrosis is not an independent disease. Chronic liver diseases caused by various etiologies, including viral hepatitis, fatty liver, alcoholic liver, etc., may lead to liver fibrosis. Liver fibrosis is an important pathological feature of chronic liver disease, and it is also the prelude and necessary intermediate link of liver cirrhosis. 25% to 40% of liver fi...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61K36/53A61P1/16
Inventor 邓瑞雪刘普梁菊尹卫平柴元武孙鲜明
Owner HENAN UNIV OF SCI & TECH
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