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Phenethyl alcohol glycoside-containing callicarpa kochiana extractive and preparation method thereof

A technology of phenethyl glucoside and extract, applied in the field of medicine, can solve the problems of low yield of phenethyl glucoside compounds, large toxic and side effects of organic solvents, unattainable concentration, etc., achieves the treatment of senile dementia, and is beneficial to industrialized production , the effect of high extraction rate

Inactive Publication Date: 2010-08-11
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented process involves creating new plant material called melon seeds that have enhanced levels of flavonoids like quercetone or caffeine due to their unique structure. These materials are extracted by various methods such as liquid nitrogen coolant immersion for 3 hours at room temperature followed by filtrate drying. By doing this they provide valuable health benefits when taken through these treatments over time.

Problems solved by technology

This patented technical problem addressed in this patent relates to developing new methods for studying plant biomarkers related to various degenerations caused by oxidized stressors like nitrogen monoxytrasonicsulfonium ion(NMTS)/dihydroxynitransferase/transglutaminase complexes (DNTF)) and chemotherapy agents targeted at different stages of neuronal injury due to amputation associated with brain tissue loss. Current techniques involve collecting samples containing pure products obtained from plants grown under specific conditions over time, but current separating and purifying processes require expensive equipment and consume significant amounts of organismsolvant resources.

Method used

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  • Phenethyl alcohol glycoside-containing callicarpa kochiana extractive and preparation method thereof
  • Phenethyl alcohol glycoside-containing callicarpa kochiana extractive and preparation method thereof
  • Phenethyl alcohol glycoside-containing callicarpa kochiana extractive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0128] Take 5kg of dried loquat leaf purple pearl and grind it into coarse powder.

[0129] Take loquat leaf purple pearl coarse powder, add 20 times of water, soak for 1 hour, heat and reflux under normal pressure for 1.5 hours, filter while hot, add 15 times of water to the dregs, heat and reflux for 1 hour, filter while hot, and combine the two extracts , concentrated under reduced pressure to a specific gravity of 1.15 (50°C), added ethanol until the alcohol content reached 60%, refrigerated for 12 hours, poured out the supernatant, filtered the remaining suspension, and combined the supernatant and filtrate. Concentrate the ethanol extract under reduced pressure until there is no alcohol smell, centrifuge at 2000rpm at 5-20°C, take the supernatant, and put it on a macroporous adsorption resin column (AB-8 type macroporous adsorption resin, produced by Tianjin Nankai University Chemical Plant), after the adsorption is saturated, first use 8 times of column volume water to ...

example 2

[0135] Take 6kg of dried loquat leaf purple pearl and grind it into coarse powder.

[0136] Take loquat leaf purple pearl coarse powder, add 30 times of water, soak for 1 hour, heat and reflux under normal pressure for 1.0 hour, filter while it is hot, add 20 times of water to the dregs, heat and reflux for 1 hour, filter while it is hot, combine the two extracts, Concentrate under reduced pressure to a specific gravity of 1.12 (50°C), add ethanol until the alcohol content reaches 60%, refrigerate for 12 hours, pour out the supernatant, filter the remaining suspension, and combine the supernatant and filtrate. Concentrate the ethanol extract under reduced pressure until there is no alcohol smell, centrifuge at 2000rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin (produced by Tianjin Nankai University Chemical Factory) to The flow rate of 2BV / h (column volume per hour) is applied to the macroporous adsorption resin column. After th...

example 3

[0138] Take 10kg of dried loquat leaf purple pearl and grind it into coarse powder.

[0139]Take loquat leaf purple pearl coarse powder, add 30 times of water, soak for 1 hour, heat and reflux under normal pressure for 1.0 hour, filter while it is hot, add 20 times of water to the dregs, heat and reflux for 1 hour, filter while it is hot, combine the two extracts, Concentrate under reduced pressure to a specific gravity of 1.12 (50°C), add ethanol until the alcohol content reaches 60%, refrigerate for 12 hours, pour out the supernatant, filter the remaining suspension, and combine the supernatant and filtrate. Concentrate the ethanol extract under reduced pressure until it has no alcohol smell, centrifuge at 2000rpm at 5-20°C, take the supernatant and add it to the treated AB-8 macroporous adsorption resin at 2BV / h (column volume per column volume) hour) flow rate on the macroporous adsorption resin column, after the adsorption is saturated, first use 6 times of column volume ...

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Abstract

The invention provides a phenethyl alcohol glycoside-containing callicarpa kochiana extractive. The main component of the attractive is phenethyl alcohol glycosides compound. The preparation method of the extractive comprises the steps of: extracting the stem leaf of callicarpa kochiana to obtain extracting solution by reflowing water or 50-75% (v/v) alcohol; and purifying the extracting solution with macroporous resin to the extractive, wherein the extractive comprises 40-55% (w/w) forsythoside A and 10-30% (w/w) verbascoside. The animal experiment shows that the extractive can strengthen or improve the learning and memory functions to normal mice and various model animals with damaged memory, and can be used for preparing the medicine for curing the senile dementia and particularly preparing the medicine for curing vascular dementia (VD).

Description

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Claims

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Application Information

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Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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