41 results about "Bis(trichloromethyl) carbonate" patented technology

The chemical synthesis method of 3-phenyl-5-methyl-4-isoxazolecarboxylic acid chloride, using bis (trichloromethyl) carbonate and 3-phenyl-5-methyl-4-isoxazolecarboxylic acid as The raw material is prepared by acyl chloride reaction in organic solvent, and the product is the key intermediate of oxacillin. The synthesis method is a chemical synthesis method of 3-phenyl-5-methyl-4-isoxazolecarbonyl chloride with reasonable process, safe and reliable production, high reaction yield, low production cost and basically no three wastes.

The invention discloses a synthetic method of emtricitabine intermediates, namely, (2R, 5S)-5-(5'-fluoro-cytimidine-1-group)-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester having the structural formula of (VI), (2R, 5S)-5-hydroxy-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester having the structural formula of (III) is taken as raw material to obtain chloro compounds having the structural formula of (IV) by chlorination reaction, then the chloro compounds (IV) are treated with condensation and hydrolyzation reactions with N, O-bis(trimethoxy)5-flurocytosin having the structural formula of (V), thus obtaining the (2R, 5S)-5-(5'-fluoro-cytimidine-1-group)-1, 3-oxathiolane-2-carboxylic acid-L-menthyl ester (VI). The invention uses bis(trichloromethyl) carbonic ester to replace the thionyl chloride in the prior art so as to be taken as a chlorination reagent, thus having the advantages of safe and reliable operation and environmental protection.

The invention discloses a lamivudine intermediate, that is, (2R,5S)-5-(5-cytosine-1-yl)-1,3-oxothioheterocycle with the structure shown in formula (VI) The synthetic method of pentane-2-carboxylic acid-L-menthyl ester is based on (2R, 5S)-5-hydroxyl-1,3-oxathiolane-2 as shown in formula (III) -Carboxylic acid-L-menthyl ester is raw material, obtains structure as the chlorinated product shown in formula (IV) by chlorination reaction, chlorinated product (IV) and structure as shown in the N of formula (V), O-bis( Trimethylsilyl) 5-cytosine condensation, hydrolysis in the system. The present invention uses bis(trichloromethyl)carbonate instead of thionyl chloride in the prior art as the chlorination reagent, and has the advantages of safe and reliable operation, and environmental protection.

The invention relates to the field of chemically synthesized drug, in particular to a new synthetic process of drug for preventing and curing poultry coccidiosis, i.e., toltrazuirl. The synthetic process includes allowing trifluoromethylthiophenol and 2-chloro-5-nitrotoluene as raw material to condense, performing the reduction reaction with hydrogen in presence of Pd / C catalyst, reacting with bis (trichloromethyl) carbonate for esterifying isocyanic acid, and finally adding diethyl carbonate and methylurea for synthesizing toltrazuirl. The new synthetic process of toltrazuirl has easy operation, simple required equipment, low pollution, easily the prior raw material, low cost, and high yield with a total one of up to about 50%.

The invention relates to the technical field of addition type carbonate flame retardants and provides a method for preparing a phenoxy tetrabromobisphenol A carbonate flame retardant. The method comprises the following steps: (1) dissolving phenol and tetrabromobisphenol A in a chloralkane solution, and uniformly stirring; (2) dissolving bi(trichloromethyl) carbonate in the chloralkane solution in a reaction container at room temperature; (3) adding a catalyst into the reaction container; (4) dropwise adding alkaline liquor and a mixture dissolving solution prepared in the step (1) into the reaction container at a constant speed, and reacting for 1-2 hours at room temperature; (5) washing the solution prepared in the step (4) until the solution does not contain chloridion, and splitting the organic layer; and (6) dropwise adding the organic layer into hot water at the temperature of 70-95 DEG C, and separating out the coarse product by crystallization. According to the method, the target product, namely phenoxy tetrabromobisphenol A carbonate is directly obtained, the molecular weight controllability of the product is improved, the operation process is simple, and the operability is high.