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30 results about "Bird flu (avian influenza)" patented technology
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A viral infection that spreads among birds, and rarely affects humans.
Gene engineering antibody of human source neutrality for anti virus H5N1 of bird flu
This invention provides a human-derived genetic engineering antibody that can specifically bond avian influenza virus H5N1. The genetic engineering antibody is derived from antibody gene library of avian influenza virus H5N1 patients in convalescence. The recombinant antibody is decided by hypervariable region (CDRs) specific gene sequence in the antibody light chain and heavy chain gene variable region, and is effectively expressed in procaryotic cells and eukaryotic cells. The recombinant antibody is a functional neutralizing antibody can specifically bond avian influenza virus haemagglutinin protein HA. Part or all genes of the antibody in CDR can modify and produce genetic engineering antibodies with different forms in procaryotic cells, yeast, insects and eukaryotic cells, and can prevent and treat diseases related to avian influenza virus H5N1.
Owner:中国疾病预防控制中心病毒病预防控制所
Recombined newcastle disease virus LaSota attenuated vaccine strain for expressing avian influenza virus H9 subtype HA protein
The invention relates to a recombinant newcastle pestilence LaSota HCLV expressing the bird flu virus H9 subtype hemagglutinin (HA) protein, in particular the recombinant newcastle pestilence LaSota is rL-H9HA. The invention further discloses a method for preparing the recombinant newcastle pestilence LaSota HCLV and the application of the HCLV in preparing a bivalent vaccine for preventing bird flu and newcastle pestilence.
Owner:HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Triple rapid detection kit of three avian respiratory diseases, and application thereof
ActiveCN104007261AStrong specificityHigh sensitivityBiological material analysisImmunoglobulins against virusesInfectious DisorderRespiratory tract disease
The invention belongs to the field of infectious disease detection of animals, and concretely relates to a triple rapid detection kit of three avian respiratory diseases, and an application thereof. The kit comprises a test paper strip, a test card shell and a sample dilution, and the test paper strip is formed by sequentially pasting an absorbing pad, a cellulose nitrate membrane, a colloidal-gold pad and a sample pad on a non-absorbent support slice; a combination pad is coated with an anti-avian influenza virus monoclonal antibody-colloidal gold marker, an anti-Newcastle disease virus monoclonal antibody-colloidal gold marker and an anti-chicken infectious bronchitis virus monoclonal antibody-colloidal gold marker mixture, detection lines T1, T2 and T3 are coated with the anti-avian influenza monoclonal antibody, the anti-Newcastle disease virus monoclonal antibody and the chicken infectious bronchitis monoclonal antibody, and the cellulose nitrate membrane is coated with a rabbit anti-rat IgG quality control line. The kit can simultaneously complete the disease cause detection of bird flu H5 type, H9 subtype, Newcastle diseases and chicken infectious bronchitis, and has strong specificity and high sensitivity.
Owner:HUAZHONG AGRI UNIV +1
Construction and application of H9N2-subtype avian influenza virus cell high-yield vaccine strain
ActiveCN105671002AHigh titerImprove adaptabilityAntiviralsViruses/bacteriophagesAnimals vaccinesEmbryo
The invention belongs to the technical field of animal vaccine preparation and particularly relates to construction and application of an H9N2-subtype avian influenza virus cell high-yield vaccine strain. The cell vaccine strain is prepared through artificially induced mutation screening of an avian influenza isolate and is named H9N2-subtype avian influenza virus W1-HA358 strain, of which an original isolate is A / duck / Hubei / W1 / 2004 (H9N2) strain. The 3rd, 5th and 8th loca of a 3'-terminal of an HA gene non-coding region of the isolate are subjected to artificial site-specific mutagenesis, and a mutation strain is saved through reverse genetic operation, wherein the mutation strain is subjected to passage on an MDCK cell until a stable generation to obtain a high-proliferation-titer virus strain, thereby producing the H9N2-subtype avian influenza virus cell vaccine. The invention solves the problem of instable proliferation of the H9N2-subtype avian influenza on the MDCK cell, and overcomes a defect of shortage of large quantity of chick embryo during outbreak of the avian influenza, thereby increasing preparation efficiency of the vaccine.
Owner:HUAZHONG AGRI UNIV
Preparation method and product of bird flu inactivated vaccine
InactiveCN102266554AOptimize and improve the production processSmall immune side effectsAntiviralsAntibody medical ingredientsImmune effectsAdjuvant
The invention discloses a preparation method of an inactivated bird flu vaccine and its product. The preparation method comprises: preparing a bird flu virus liquid; adding formaldehyde to the bird flu virus liquid to inactivate the virus liquid; adding an adjuvant to the inactivated virus liquid , emulsified, and obtained; wherein, before adding the adjuvant to the inactivated virus liquid, the virus liquid is subjected to the following treatment: the inactivated virus liquid is concentrated, and the concentrated virus liquid is diluted. The present invention aims at the production status of avian influenza inactivated vaccines, optimizes and improves the production process of avian influenza vaccines, does a large number of experiments on the relationship between formaldehyde concentration and immune titer, and uses virus Concentration technology effectively removes formaldehyde residues in vaccine products. Compared with existing avian influenza inactivated vaccines, the method of the present invention effectively removes 75% of formaldehyde residues in vaccine products, and the prepared avian influenza inactivated vaccines have immunity Small side effects, long storage period, high antibody level and other advantages.
Owner:哈药集团生物疫苗有限公司
Fusion protein sHA1-Fc and application
InactiveCN106117369AProtect animal organismsSimple and efficient operationSsRNA viruses negative-senseAntibody mimetics/scaffoldsSpecific immunityFc fragment
The invention discloses fusion protein sHA1-Fc and an application. The fusion protein sHA1-Fc of a highly pathogenic AIV (avian influenza virus) H5N1 and a chicken IgY Fc fragment is expressed by a Bacto-Bac expression system, has a molecular structure similar to IgY, and can penetrate a respiratory tract mucosal barrier of a chicken to enter the body under transfer of FcRy expressed in epithelial cells. A sequence of an sHA1-Fc fusion gene is represented as SEQ ID NO:1. The fusion protein is supplemented with a mucosal adjuvant and inoculates the chicken through nasal inhalation, thereby being capable of triggering an organism to generate effective mucosal immunity and triggering systemic immunity of the organism. Therefore, the organism is enabled to obtain anti-AIV local specific immunity and systemic immunity, the immune effect of the fusion protein is better than that of a commercial inactivated virus vaccine, and a new strategy is provided for development of a novel mucosal vaccine for poultry bird flu and other infectious diseases.
Owner:HUAZHONG AGRI UNIV
Separation, identification and application of avian H9N2 subtype avian influenza virus strain
ActiveCN111057682AGood correlationProtection attackSsRNA viruses negative-senseViral antigen ingredientsAnimal virusAdjuvant
The invention relates to the field of animal virology, and provides separation, identification and application of an avian H9N2 subtype avian influenza virus strain. The H9N2 subtype avian influenza virus strain is preserved in China General Microbiological Culture Collection Center on July 02, 2019 with the preservation number of CGMCC No. 18172. The antigen variation condition of the separated strain is explained from the molecular level; the virus strain is inactivated with formaldehyde, and then is processed together with a 605 adjuvant to prepare an inactivated vaccine, 21-day-old SPF chickens are immunized, the immune effect is evaluated through a serological method and an immune challenge method, it is proved that the strain is good in protection effect, and the strain can be used as an avian influenza H9N2 subtype vaccine candidate strain. The invention provides an idea for bird flu prevention and control, provides technical teaching for bird flu candidate strain screening, andhas great public health significance.
Owner:BEIJING HUAXIA XINGYANG BIOLOGICAL SCI & TECH +1
Chinese medicine feed additive for avian influenza prevention
The present invention discloses a Chinese medicine feed additive for avian influenza prevention, which is characterized in that raw materials of the Chinese medicine feed additive comprise, by weight: 10 to 15 parts of hypericum perforatum, 10 to 15 parts of heartleaf houttuynia herb, 5 to 10 parts of folium perillae and 15 to 20 parts of rosa laevigata. According to the present invention, the Chinese medicine feed additive has effects of clearing heat, removing toxicity, fighting bacteria, eliminating inflammation, treating common cold, wind cold, aversion and fever of cold, and enhancing immunity. Adding the Chinese medicine feed additive to poultry feed can effectively prevent poultry from being infected with bird flu virus, and has no potential side effects on people who eat the poultry.
Owner:CENXI FOREIGN TRADE CHICKEN FARM COMPANY
Compound astragalus polysaccharide granule for preventing and treating avian influenza
PendingCN113855729ASolve the problem of preventive medicineOrganic active ingredientsAntiviralsBiotechnologyAngelica Sinensis Root
The invention discloses a compound astragalus polysaccharide granule for preventing and treating avian influenza, which can effectively solve the problem of drug use for avian influenza, and adopts the technical scheme that the compound astragalus polysaccharide granule is prepared from the following raw material drugs in parts by weight: 20-30 parts of astragalus, 10-20 parts of honeysuckle, 15-35 parts of radix isatidis, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of angelica sinensis, 10-30 parts of fructus forsythiae, 20-30 parts of radix ranunculi ternati and 5-15 parts of semen momordicae, and after the raw material drugs are extracted and concentrated by adopting the modern process, and auxiliary materials are added to prepare granules, wherein auxiliary materials are one or mixture of more than two of starch, powdered sugar and dextrin. According to the compound astragalus polysaccharide granule, the raw materials are rich, the price is low, the medication is safe, no irritation or toxic-side effect is generated on poultry, the bird flu prevention and treatment effect on poultry is good, the compound astragalus polysaccharide granule is good in use effect, and is an innovation of traditional Chinese veterinary medicines for preventing and treating avian influenza. Meanwhile, the preparation method is simple, the cost is low, the use is convenient, the prevention effect on the bird flu of poultry is very good, and the compound astragalus polysaccharide granule is suitable for large-scale popularization and application.
Owner:河南纳瑞森生物药业有限公司 +2
Method and test strip for rapid detection of avian influenza and human influenza susceptible population
ActiveCN106771120BPracticalEasy to detectDisease diagnosisBiological testingSaliva sampleSusceptible population
The invention discloses a method for rapidly detecting susceptible populations of bird flu and human flu and a test strip, including a sample pad, a gold standard pad, a detection and control area arranged in sequence along the chromatographic direction, and a pad for absorbing excess liquid in the detection sample. Water-absorbing pad; The detection and control area includes a detection zone and a quality control line arranged in sequence; The gold standard pad includes colloidal gold-labeled lectin MAL-II or SNA; A stable internal control lectin or a stable internal control lectin that does not bind to the lectin SNA. Insert one end of the sample pad of the test strip into the saliva sample or contain it in the oral cavity. After 10 to 15 minutes, take out the test strip, observe the color development state of the test strip and the quality control line, and obtain the test result. The invention truly realizes non-invasive , Safe and simple detection of avian influenza and human influenza virus susceptible populations.
Owner:陕西中药研究所
A rapid detection method for distinguishing between strong and weak viruses of h7n9 subtype avian influenza virus
ActiveCN109680101BQuick judgmentHigh sensitivityMicrobiological testing/measurementDNA/RNA fragmentationNucleotideBird flu (avian influenza)
The invention provides a rapid detection method for distinguishing the strong and weak viruses of H7N9 subtype avian influenza virus. By comparing the nucleotide sequences of the HA and NA genes of the H7N9 subtype avian influenza virus isolated in recent years, they are respectively designed in their conserved regions. Primers and probes were identified, and a real-time fluorescence quantitative RT-PCR nucleic acid rapid detection method that can distinguish between strong and weak H7N9 subtype avian influenza virus was established. The real-time fluorescent RT-PCR method for distinguishing the strong and weak viruses of the H7N9 subtype avian influenza virus provided by the present invention can detect and distinguish the strong and weak viruses of the H7 subtype avian influenza virus in the same reaction tube, and can also detect the N9 subtype bird flu virus. It has high sensitivity, short detection time, and does not require open links such as electrophoresis. It can be completed in a closed reaction tube with only one fluorescent PCR instrument, and the reaction curve can be viewed in real time during the detection process to make a quick judgment on the result.
Owner:CHINA ANIMAL HEALTH & EPIDEMIOLOGY CENT
A kind of traditional Chinese veterinary medicine against chicken Newcastle disease virus disease and avian influenza and preparation method thereof
The invention relates to a traditional Chinese veterinary medicine for resisting chicken Newcastle disease virus disease and avian influenza, which is prepared from the following components in parts by weight: 10-50 parts of honeysuckle, 10-50 parts of Houttuynia cordata, 6-20 parts of Daqingye, and 8 parts of forsythia ~40, Scutellaria baicalensis 10~40. The invention also discloses a preparation method of the traditional Chinese veterinary medicine against chicken Newcastle disease virus disease and bird flu. The composition of the invention has reasonable formula and synergistic effect, and has obvious control effect on chicken Newcastle disease virus disease and prevention and treatment of avian influenza; it is green, safe, stable, easy to transport and store; it is used for drinking water administration, convenient to use, and has good efficacy. The application and popularization prospect; the preparation method is simple; the resource-rich medicinal materials are used in the compound preparation, which reduces the cost; at the same time, no drug residues will be generated in chicken products, which is beneficial to ensuring food safety.
Owner:山东德信生物科技有限公司 +1
A kind of bird flu synthetic peptide vaccine and preparation method thereof
ActiveCN109206492BSynthetic Effective CopingNo biosecurity issuesSsRNA viruses negative-senseViral antigen ingredientsChemical synthesisEngineering
Owner:CHINA ANIMAL HUSBANDRY IND
A feed feeding device capable of preventing bird flu
The invention relates to the technical field of breeding fodder production, and discloses a fodder feeder capable of preventing avian influenza. The fodder feeder comprises a shell, multiple flow guiding holes are formed in the shell, clamping grooves are formed in the portion, outside the flow guiding holes, of the shell, the flow guiding holes are located in the bottom of the clamping grooves, the edges of the clamping grooves are hinged with clamping plates, a fodder ball against each clamping groove is arranged on the exterior of the shell, a pushing plate matched with each clamping groove is arranged between each fodder ball and the corresponding clamping groove, a medicine liquid ball is arranged in the shell, multiple through holes are formed in the medicine liquid ball, all the through holes are sealed by films, steel wires are arranged in the shell and wrapped with cotton threads, one end of each steel wire is fixed to each film, the other end of each steel wire penetrates the corresponding flow guiding hole and pushing plate and is fixed to the pushing plate, the end, penetrating the corresponding pushing plate, of each steel wire penetrates into the corresponding fodder ball , and the cotton threads are connected between the adjacent steel wires. By means of the fodder feeder, the defect can be overcome that existing fodder needs to be mixed with medicine manually, and medicine efficacy failure is prevented.
Owner:贵州松羽禽业有限公司
A traditional Chinese medicine feed additive for preventing bird flu
Owner:CENXI FOREIGN TRADE CHICKEN FARM COMPANY
A kind of bursa active hexapeptide for promoting the immune response of bird flu and/or Newcastle disease vaccine and its application
ActiveCN109180784BImproving immune potencyImprove immune activityViral antigen ingredientsAntiviralsAnimals vaccinesImmunogenicity
The invention relates to isolation, identification and application of a Fabricius bursa active hexapeptide for promoting an immunoreaction of avian influenza and / or a Newcastle disease bivalent vaccine. The Fabricius bursa active hexapeptide has an amino acid composition of Lys Gly Asn Arg Val Tyr, has a simple structure and is extremely weak in immunogenicity. The active peptide has the functionof promoting the immune response of the vaccine and can promote the antibody reaction against the AIV antigen and the antibody reaction against the NDV antigen in the mouse in the mouse immunization experiment. The active peptide can promote the cellular immune response, improve lymphocyte viability and an antigen presentation reaction and improve the vaccine immunopotency, can be used as a vaccine adjuvant or immunopotentiator in animal vaccine application research, can improve the immune response of animal organisms to specific antigens, can improve the immune efficacy of vaccines and can improve the ability of animal organisms resisting epidemic disease infection.
Owner:NANJING AGRICULTURAL UNIVERSITY
Method for detecting bird flu and avian infectious bronchitis viruses in livestock farm
InactiveCN113881809APrecisely control the control effectAvoid infectionMicrobiological testing/measurementDNA/RNA fragmentationDiseaseBird flu (avian influenza)
The invention provides a method for detecting bird flu and avian infectious bronchitis viruses in a livestock farm, and relates to the field of biological detection. The method for detecting bird flu and avian infectious bronchitis viruses in the livestock farm comprises the following steps: S1, designing and synthesizing a digital PCR primer probe; S2, selecting and treating a sample; S3, carrying out RT-dPCR process operation; S4, performing a dual RT-dPCR sensitivity experiment; and S5, performing a dual RT-dPCR specificity experiment, wherein the avian influenza virus primer probe group comprises AIV-F, AIV-Probe and AIV-R, and the avian infectious bronchitis virus primer probe group comprises IBV-F, IBV-Probe and IBV-R. By detecting the two pathogens through adoption of the detection method, not only can the detection sensitivity be improved, but also samples with low virus content can be detected, the disease control effect can be accurately controlled, large-scale avian influenza infection is avoided, the economic loss of breeding enterprises is reduced, the detection method can also be used for simultaneously detecting the two pathogens, and therefore, the detection efficiency is obviously improved.
Owner:山东省动物疫病预防与控制中心
Compound astragalus polysaccharide soluble powder for preventing and treating avian influenza
PendingCN113750132AAbundant raw materialsLow priceOrganic active ingredientsPowder deliveryBiotechnologyAstragalus polysaccharide
The invention relates to compound astragalus polysaccharide soluble powder for preventing and treating bird flu, which can effectively solve the problem of medicine use for avian influenza, and adopts the technical scheme that the soluble powder is prepared by taking 550-650g of astragalus polysaccharide, 180-220g of achyranthes bidentata polysaccharide, 110-130g of radix ranunculi ternati polysaccharide and 75-85g of semen momordicae cream as raw material medicines and adding auxiliary materials accounting for 3% of the weight of the raw material medicines, wherein the auxiliary material is prepared by uniformly mixing powdered sugar and dextrin according to the weight ratio of 4: 1, crushing, drying at 60 DEG C, and sieving with a 80-mesh sieve. The traditional Chinese veterinary medicine is rich in raw materials, low in price, safe in medication, free of toxic and side effects and good in use effect, and is an innovation of traditional Chinese veterinary medicines for preventing and treating avian influenza.
Owner:河南纳瑞森生物药业有限公司 +2
Pharmaceutical composition for treating avian influenza and preparation method thereof
InactiveCN111544561AImprove immunityImprove stress resistanceInorganic active ingredientsAntiviralsBiotechnologySide effect
The invention discloses a pharmaceutical composition for treating avian influenza. The pharmaceutical composition comprises the following components in parts by weight: 10-16 parts of cornu bubali, 35-55 parts of nacre, 18-26 parts of bryozoatum, 18-26 parts of fructus gardeniae, 10-16 parts of fructus arctii, 10-16 parts of roasted herba ephedrae, 6-12 parts of fresh ginger, 6-12 parts of rhizomapicrorhizae, 6-12 parts of rhizoma acori graminei and 4-8 parts of liquorice. The composition has the advantages of being small in toxic and side effects, free of drug resistance, not prone to residues and the like, the organism immunity and the anti-stress capacity of poultry can be remarkably improved, and bird flu generation and transmission are resisted.
Owner:SHIJIAZHUANG HENGTAIHE ANIMAL PHARMACY CO LTD
Method of preparing Oral liquid vaccine for preventing and controlling avian influenza of domestic animals and domestic birds
InactiveCN101279028BReduce infection rateBird flu prevention and controlUnknown materialsPlant ingredientsBird fluZoology
The invention relates to a veterinary pharmaceutical composition and a preparation method thereof. The veterinary pharmaceutical composition of the invention is a vaccine oral solution for the prevention and the treatment of bird flu of domestic animal and fowl, and is prepared by the raw materials according to the following parts by weight: 10 to 20 parts of forsythia suspensa, 10 to 25 parts ofasarum, 5 to 20 parts of ilex pubescens, 15 to 30 parts of rhizoma anemarrhenae, 8 to 20 parts of wild chrysanthemum, 10 to 20 parts of polygalae, 10 to 25 parts of lobelia chinensis, 2 to 5 parts ofsnake galls, 10 to 25 parts of ox to gall, 40 to 60 parts of aloe, 25 to 40 parts of rock sugar, 5 to 15 parts of rimantadine and 3 to 10 parts of azithromycin. The oral solution of the invention canbe directly used as daily feed for feeding domestic animals and fowl, which can effectively inhibit bird flu virus, reduce the infection rate of respiratory tract and lung and prevent domestic animaland fowl from being infected by bird flu.
Owner:辽宁天鹏生物科技股份有限公司
Feed additive for preventing and treating bird flu and preparation method thereof
ActiveCN105901381BImprove the immunityImprove immunityAnimal feeding stuffAccessory food factorsBiotechnologyAnimal science
The invention relates to a feed additive for preventing avian influenza; the feed additive is composed of the following raw materials in parts by weight: 30-60 parts of folium isatidis, 20-40 parts of common St.John's wort herb, 10-30 parts of radix astragali, and 10-25 parts of liquorice. The invention also discloses a preparation method of the feed additive. The feed additive not only can prevent and control avian influenza but also can improve the immunity of animals, and has the characteristics of small side effects, low cost, simple process and easy industrialization.
Owner:INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
A kind of avian influenza virus-like particle antigen, vaccine and its preparation method and application
ActiveCN112079905BGood cross reactivityInhibition of replicationSsRNA viruses negative-senseAntibody mimetics/scaffoldsBird fluEmbryo
The invention discloses an avian influenza virus-like particle antigen, a vaccine and its preparation method and application. It is formed by self-assembly of a recombinant baculovirus transfected insect cells based on serial expression of H7N9 subtype avian influenza virus HA, NA, and M1 genes Bird flu virus-like particle antigen; the virus-like particle antigen prepared by the present invention is used to prepare vaccine. The vaccine prepared by the invention can produce higher titers of HI antibody, neutralizing antibody and IgY antibody after immunizing chickens, can provide 100% clinical protection against H7N9 subtype highly pathogenic avian influenza virus, and can effectively inhibit shedding . The invention does not rely on chicken embryos, has low production cost and short cycle; only one immunization with a low dose can induce strong protective ability. The invention provides a basis for the industrialized production of VLP vaccines.
Owner:YANGZHOU UNIV
Method for expressing duck-derived avian influenza virus ns1 protein and application of the method
ActiveCN108130340BEfficient expressionStable expressionSsRNA viruses negative-senseVirus peptidesTGE VACCINEMetallothionein
The present invention relates to a method for expressing the NS1 protein of duck-derived avian influenza virus and the application of the method. The method mainly includes the following steps: (1) construction of Tetrahymena expression vector pD5H8-NS1; (2) Tetrahymena recombinant cells Construction and screening of strains; (3) induced expression and identification of NS1 protein; the application of the NS1 protein expression method of duck-derived avian influenza virus is used in the preparation of avian influenza virus differential diagnosis kit and vaccine preparation, the present invention Tetrahymena expression system is selected as the expression system of duck-derived avian influenza virus NS1 protein, which can efficiently and stably express duck-derived avian influenza virus NS1 protein. The transgenic expression vector pD5H8 used in the Tetrahymena cell expression system selected by the present invention contains high The metallothionein gene MTT5 promoter provides an important guarantee for the high-efficiency expression of foreign genes in Tetrahymena.
Owner:INST OF ANIMAL HUSBANDRY & VETERINARY FUJIAN ACADEMY OF AGRI SCI +1
A kind of traditional Chinese medicine granules for preventing and treating bird flu and improving immunity of chickens and preparation method thereof
ActiveCN108403866BImprove immunityLow cost of treatmentAnthropod material medical ingredientsAntiviralsHouttuyniaTherapeutic effect
The invention discloses a traditional Chinese medicine granule for preventing and treating bird flu and improving the immunity of chicken flocks and a preparation method thereof, belonging to the technical fields of animal husbandry and veterinary medicine and traditional Chinese medicine. ~15 parts, Nepeta 8~16 parts, mulberry leaves 10~20 parts, Astragalus 10~25 parts, Guanzhong 3~15 parts, Schisandra chinensis 10~20 parts, honeysuckle 10~25 parts, Echinacea chinensis 15~25 parts, fish 10-18 parts of Houttuynia cordata, 8-15 parts of Clover, and 3-12 parts of Vitex. The traditional Chinese medicine granule provided by the invention has reasonable formula, low cost, convenient drug material acquisition, simple preparation, remarkable preventive and therapeutic effects on bird flu, can improve the immunity of chickens, and has no toxic and side effects.
Owner:CHINA ANIMAL HEALTH & EPIDEMIOLOGY CENT
Chicken feed feeding equipment for preventing bird flu
InactiveCN107646733BRealize automatic mixingGuaranteed efficacyFodderAvicultureBird fluBreeding chicken
Owner:贵州松羽禽业有限公司
Medicine for preventing and treating bird flu and preparation method thereof
The invention discloses a drug for preventing and curing avian influenza. The drug is prepared through the steps as follows: firstly, measuring raw materials: measuring the following raw materials in parts by weight: 71-87 parts of astragali radix, 71-87 parts of taraxacum, 71-87 parts of sculellaria barbata, 29-35 parts of glycyrrhiza, 71-87 parts of grassleaf sweelflag rhizome, 71-87 parts of panax ginseng, 72-87 parts of privet leaves, 72-87 parts of folium isatidis, 71-87 parts of horsetail, 72-88 parts of uncaria, 86-106 parts of lotus roots, 71-87 parts of rosa laevigata, 72-88 parts of mentha; secondly, crushing and uniformly mixing the raw materials, and obtaining the drug for preventing and curing avian influenza. According to the invention, the immunity of the poultry uninfected by avian influenza virus such as chickens and ducks can be improved if the drug is taken in advance, and the drug is good in prophylactic effect and has an excellent curing effect on the poultry with the symptoms of avian influenza.
Owner:衡阳市武顺循环农牧绿色生态科技有限公司
Novel antiviral peptide against avian influenza virus h9n2
InactiveUS20110135676A1Preventing disease and spreadHinders its propagationSsRNA viruses negative-senseBiocideBinding siteAvian influenza virus
The present invention relates to recombinant phages carrying fusion peptides that bind to avian influenza virus (AIV). Such phages are useful as diagnostic reagents to replace anti-AIV antibodies because the phages are capable of competing with the latter antibodies for binding sites on the virus. Synthetic peptides with the sequence CNDFRSKTC, either in linear or cyclic conformations, or fusion phages bearing the above said peptides inhibited AIV propagation in embryonated egg as well as in MDCK cell lines. Therefore they may be used as'therapeutic agents to control, to treat and to eradicate bird flu caused by avian influenza virus.
Owner:UNIVERSITI PUTRA MALAYSIA
A kind of preparation method of recombinant baculovirus vaccine for prevention and treatment of avian influenza h5n1
The invention relates to a preparation method of a recombinant baculovirus vaccine for preventing and treating avian influenza H5N1, in particular to an H5N1 virus vaccine strain for expressing avian influenza virus hemagglutinin HA gene and a preparation method thereof. The preparation method concretely comprises the following steps of 1) building pS-ITRs-HA plasmids; 2) converting the pS-ITRs-HA plasmids into E .coli DH10 Bac; 3) transfecting Sf9 insect cells by recombinant baculovirus shuttle vectors; 4) amplifying the recombinant baculovirus. When the recombinant H5N1 virus vaccine strain obtained through preparation is used for performing immunodetection on blood serum of immune chicken; the level of IgG antibodies in the blood serum of the immune chicken can reach 0.966 to the highest degree; the concentrations of IL-2, IL-4 and IFN-gamma can respectively reach 89 .67ng / L, 80 .21ng / L and 64 .24ng / L to the highest degree. The results show that the recombinant baculovirus vaccine can effectively irritate the chicken bodies to simultaneously generate the body fluid immunity and the cell immunity; the dual immunity protection effect is provided for the chicken group; the invention lays the theoretical foundation for the research and development of the avian influenza virus based on the baculovirus.
Owner:HEILONGJIANG UNIV
A kind of algae feed that can prevent bird flu and its application
ActiveCN103820459BReduce manufacturing costImproving immunogenicityUnicellular algaeMicroorganism based processesAntigenChlamydomonas reinhardtii
The invention discloses an algae feed capable of preventing avian influenza and application thereof, discloses an artificially synthesized avian influenza antigen gene optimized by a codon preferred by chlamydomonas reinhardtii, establishes a recombined expression vector suitable for expressing the avian influenza antigen gene in the chlamydomonas reinhardtii, and transfers the recombined expression vector into host chlamydomonas reinhardtii to obtain transgenic chlamydomonas reinhardtii. Animal experiments show that a mouse eating the transgenic chlamydomonas reinhardtii can generate an avian influenza antibody; the algae feed has a wide application prospect and can prevent the avian influenza.
Owner:深圳市微宇藻业科技有限公司
Avian influenza virus latex agglutination assay kit and its use
The invention discloses a reagent box of latex agglutination which is used for quickly detecting the birds flu virus. Putting the hare birds flu anti-virus nuclein IgG couple to the surface of carboxylation polystyrene latex particles, founding the method to test the latex agglutination of birds flu virus, then supplemented by other match reagents prepared the reagent box of detect the bird flu virus latex agglutination. the reagent box of detect the bird flu virus latex agglutination is composed of box body and latex diagnostic reagents, sample handling liquid of A which is located in box, sample handling liquid of B, positive contrast sample and negative contrast sample. The reagent box is referred directly detect the birds flu virus, its notable advantages are that strong specificity, high sensitivity, simple operation and rapid diagnosis.
Owner:WUHAN KEQIAN BIOLOGY CO LTD
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