104 results about "Aortic rings" patented technology

The invention relates to actuators based on electroactive polymeric materials for use in pumping fluids or in other applications where a contractile actuation is required, in particular although not necessarily exclusively for use in vascular pulsation devices such as a variable aortic tension device. Embodiments disclosed include an actuator (10) comprising: an inner tubular structure (15, 12); an outer tubular structure (13, 14) surrounding the inner tubular structure (15, 12) and comprising a plurality of layers of a dielectric elastomeric material (13) and a tubular elastic support structure (14), the elastic support structure (14) configured to maintain a pre-stress in the layers of the dielectric elastomeric material (13), wherein the outer tubular structure (13, 14) is configured to contract in a radial direction around the inner tubular structure (12, 15) upon application of an actuation voltage signal across the dielectric elastomeric material layers (13).

The combination of amlodipine and atorvastatin act to synergistically synthesize NO production. Moreover, the addition of a tertiary compound complements this combination of amlodipine and atorvastatin in NO production.

The invention discloses application of FAM210B in the preparation of diagnostic tools for abdominal aortic aneurysm. Experiments prove that FAM210B has expression differences in normal control tissues and abdominal aortic aneurysm tissues; therefore, it is reckoned that FAM210B is a molecular marker for diagnosing abdominal aortic aneurysm. Experiments via in-vitro cultured cells prove that by accelerating the expression of FAM210B, it is possible to inhibit the apoptosis of human aortic smooth muscle cells; therefore, it is reckoned that FAM210B is a drug target for treating abdominal aortic aneurysm. As a new molecular marker for diagnosing and treating abdominal aortic aneurysm, the molecular marker has a promising clinical application prospect.

The invention provides a method for obtaining an interested aortic pressure curve, and a storage medium. The method comprises the following steps of obtaining aortic pressure Pa data; extracting a stable pressure waveform according to the aortic pressure Pa; generating an aortic pressure waveform image according to the stable pressure waveform; obtaining a moment of interest; and selecting a corresponding aortic pressure curve from the aortic pressure waveform image according to the interested moment. According to the method, the interested aortic pressure curve part can be obtained from the continuous aortic pressure curve, in this way, the influence of the objective environment can be avoided, and meanwhile the defect that clinically analyzing the aortic pressure curve only depends on observation and experience is overcome.

The present invention is directed to methods and compositions for preventing or reducing atherosclerotic lesions and plaques. Specifically, the instant invention provides methods for using humanin and its analogues to prevent or reduce the formation of atherosclerotic plaques. Also provided are methods of using humanin and its analogues to improve the survival of endothelial cells, particularly aortic endothelial cells.

The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compositions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments, in combination with an inhibitor of the discoidin (DS) domain of ACLP, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of ACLP-mediated activation of a member of the TGFβ receptor superfamily.

The invention relates to a recombinant virus silencing a T1 protein, and a construction method and an application thereof, and belongs to the technical field of biomedicine. Firstly, a shRNA silencingthe T1 protein is designed and synthesized and then is introduced into a viral vector, and then the viral vector is packed to prepare the recombinant virus silencing the T1 protein. The recombinant virus can highly efficiently infect aorta endothelium in mouse bodies, is expressed in aortic endothelial cells for a long time, can protect integrity of endothelial barrier of atherosclerotic model mice, promotes the expression of endothelial cadherin, and significantly inhibits the development of atherosclerosis. The recombinant virus silencing the T1 protein is expected to become a genetic drugfor treatment of atherosclerosis related diseases.

The invention belongs to the technical field of pharmaceutical preparations and nanomedicine, and relates to a bionic nano-drug for preventing and treating aortic dissection, in particular to a mononuclear/macrophage membrane bionic modified multidrug co-loaded anti-inflammatory liposome and a preparation method thereof. The liposome is composed of cationic phospholipid and neutral phospholipid, co-loading of multiple anti-inflammatory drugs can be achieved in the liposome, anti-inflammatory cell-penetrating peptide is covalently modified on the surface of the liposome, and then mononuclear/macrophage membrane protein is used for bionic modification. According to the bionic anti-inflammatory liposome, multiple receptors and adhesion molecular ligands mediated and chemotactic on the surface of a mononuclear/macrophage membrane are utilized to realize a natural targeting effect on an inflammatory site, and non-specific clearance of a reticuloendothelial system (RES) to the liposome is reduced by virtue of modification of leukocyte self-recognition molecules. The bionic anti-inflammatory lipidosome can effectively cross a vascular endothelial barrier, gather and release anti-inflammatory drugs at the early lesion part of the aortic dissection in a targeted manner, play a synergistic anti-inflammatory role, inhibit inflammation-related cells from chemotaxis and infiltration into the lesion part, and further prevent and treat the occurrence and development of the aortic dissection.

The invention provides a preparation method of a single-cell suspension of aortic cells, which comprises the following steps: firstly treating aortic vascular tissues, and then carrying out secondary digestion reaction to obtain the single-cell suspension with high single cell yield, large quantity, high cell activity and strong cell function. The technical problem that a traditional aortic cell single-cell suspension is low in efficiency, and obtained cells are poor in quality is solved.

A pulse wave conduction parameter measurement system and method comprises: acquiring, by one or more processors, first vibration information of a supine subject from a first fiber optic sensor, the first fiber optic sensor being configured to be placed under a back region corresponding to the fourth thoracic vertebral body of the supine subject (step 711); acquiring, by the one or more processors, second vibration information of the supine subject from a second fiber optic sensor, the second fiber optic sensor being configured to be placed under a lumbar region corresponding to the fourth lumbar body of the supine subject (step 713); and generating, by the one or more processors, first hemodynamic related information on the basis of the first vibration information, and generating second hemodynamic related information on the basis of the second vibration information (step 715), thereby determining an aortic Pulse Wave Transit Time of the supine subject (step 719).

The invention discloses a preparation method and application of inonotus obliquus polysaccharide. Through water extraction and alcohol precipitation, repeated freeze thawing, deproteinization, dialysis, freeze drying, affinity chromatography and other methods, a polysaccharide component with antioxidant and anti-aging functions is separated and purified from inonotus obliquus; the inonotus obliquus polysaccharide component has strong antioxidant activity; through pretreatment of the inonotus obliquus polysaccharide, etoposide-induced proliferation inhibition and apoptosis of rat aortic smoothmuscle cells can be inhibited, and etoposide-induced cellular senescence beta-galactosidase activity increase, senescence-related heterochromatin aggregation and mitochondrial membrane potential decline can be inhibited; through pretreatment of the inonotus obliquus polysaccharide, etoposide-induced increase in expression levels of p53, p21 and p16 protein and mRNA can be inhibited. The inonotus obliquus polysaccharide components prepared according to the preparation method provided by the invention has good antioxidant and anti-aging activity and has a broad application prospect as a novel anti-aging protective medicine.

The embodiment of the invention discloses an aortic dissection evaluation method anddevice, equipment and a storage medium. The method comprises acquiring a to-be-processed image and clinical information of a current object, and constructing a geometric model comprising a target segmentation part according to the to-be-processed image; meshing the geometric model, determining an inlet and at leastone outlet of the geometric model, determining boundary conditions of the inlet and at least one outlet of the geometric model according to the to-be-processed image and the clinical information, andperforming hemodynamic simulation based on the boundary conditions; verifying the hemodynamic simulation result according to the clinical information; when the hemodynamic simulation result does notpass the verification, adjusting the boundary conditions of the geometric model, and performing hemodynamic simulation on the geometric model based on the adjusted boundary conditions; and taking theverified hemodynamic simulation result as an evaluation result of the aortic dissection. The aortic dissection is evaluated from the perspective of hemodynamics, and the accuracy of an aortic dissection evaluation result is improved.

The invention provides an instantaneous waveform-free ratio generation method and a device thereof, equipment and a medium, and the method comprises the steps: building the corresponding relation between the pressure waveform features of an aorta and the coordinates of a target point through the self-learning capability of an artificial neural network with a feature enhancement layer; obtaining the current pressure waveform features of the current aorta of the patient; and determining a current target point coordinate corresponding to the current pressure waveform feature through the corresponding relation; specifically, the step of determining the current target point coordinates corresponding to the pressure waveform feature comprises the steps that the target point coordinates corresponding to the pressure waveform feature which is same as the current pressure waveform feature in the corresponding relation are determined as the current target point coordinates; and a current instantaneous waveform-free ratio is generated according to the current target point coordinate. The high-level space information is used for positioning a target point, so that the information expression robustness is higher, the feature enhancement layer is added, and unobvious feature points caused by individual differences can be positioned.

The invention discloses application of millet bran active polyphenol in preparation of a product for preventing and treating atherosclerosis. Experiments prove that the millet bran active polyphenol can significantly inhibit migration ability of human aortic smooth muscle cells, can significantly inhibit lipid phagocytosis ability of the human aortic smooth muscle cells and human mononuclear macrophages, and can inhibit formation of in-vivo atherosclerotic plaques, thereby preventing and treating atherosclerosis. The millet bran active polyphenol is taken as a main component and can be used for preparing functional foods or medicines for preventing and/or treating atherosclerosis.

The invention provides a primary mouse thoracic aortic endothelial cell separation and culture method, which solves the problems of great difficulty in primary VECs (vascular endothelial cell) in-vitro culture, low cell activity and little output in the prior art. The method comprises: (Step 1) a mouse thoracic aortic section is obtained, and after separation and purification, the mouse thoracic aortic section is produced into an aortic ring; (Step 2) a matrigel is used for pretreating the bottom of a culture vessel; (Step 3) the aortic ring is inoculated to the surface of the matrigel, an endothelial cell culture medium which contains an endothelial cell growth-assisting factor and heparin is then added into the culture vessel for culture; (Step 4) after 3 to 7 days of culture, the aortic ring is removed, and culture is continued. The method is easy and convenient to implement, economical and applicable, and has the advantages of decreasing the probability of impurity cell contamination, increasing the survival rate and output of cells, enabling VECs to have high activity and high multiplication rate, etc..

The invention belongs to the technical field of aortic aneurysm auxiliary diagnosis, and particularly relates to a deep learning-based computed tomography aortic aneurysm auxiliary diagnosis method, which comprises the following steps of: 1, data acquisition: firstly, retrospectively collecting a plurality of common CT scans with aorta from a hospital area of a hospital; 2, data processing: dividing the data into three data sets: a training set, an internal test set and an external test set; and 3, establishing a model, constructing an auxiliary diagnosis tool by using an Attention-Unet convolutional neural network, evaluating the risk, detection sensitivity, specificity and accuracy of the aortic aneurysm in a test set by using the auxiliary diagnosis tool. The method is reasonable in design and has good diagnosis capability on aortic aneurysm; when the method is used in combination with radiologists, the film reading and decision-making capabilities of the radiologists can be remarkably enhanced, and the overall strength of imaging departments is improved. Therefore, the performance of the advanced technology proves that the non-invasive, cheap and convenient method has the potential of clinical tests.