The invention discloses an environment-friendly high-barrier multi-layer coextrusion medical transfusion film. The medical transfusion film adopts a seven-layer film compound structure and comprises an A layer, a B layer, a C layer, a D layer, an E layer, an F layer and a G layer which are successively arranged from outside to inside, wherein the A layer is a mixed resin outer layer prepared from PCCE and PEN by reacting, blending and esterification; the B layer is a first bonding layer composed of an ethylene methyl acrylate copolymer; the C layer is a secondary-core layer composed of metallocene linear polyethylene; the D layer is a core layer composed of a high-temperature resistant ethylene-vinyl alcohol copolymer; the E layer is a secondary-core layer composed of the metallocene linear polyethylene; the F layer is a second bonding layer composed of metallocene linear polyethylene grafted maleic anhydride; and the G layer is an inner layer composed of an ethylene-propylene copolymer. The medical transfusion film has the characteristics of environmental friendliness, good transparency, excellent thermal weldability, high-temperature resistance, chemical resistance, high barrier property, etc., and can be extensively applied to the field of high-barrier medical transfusion packaging.