The invention discloses an application of myricetrin for preventing and treating
osteoporosis. Myricetrin is free from toxic effect on human mesenchymal stem cells, does not affect
cell proliferation, has a protective effect on
apoptosis of the human mesenchymal stem cells caused by H2O2, improves the
oxidative stress state induced by H2O2 in the differentiation process, has a protective effect on ossifying differential inhibition of
human bone mesenchymal stem cells caused by H2O2, has an inhibiting effect on enhancement of adipogenic differentiation of
human bone mesenchymal stem cells caused by H2O2, and can inhibit expression of bone absorption factors so as to improve
apoptosis and differential inhibition of the human mesenchymal stem cells and indirectly inhibit
osteoclast activation to protect
osteoporosis. In an osteoporotic model of a castrated mouse, the myricetrin can improve the
oxidative stress state in serum and improve the bone micro-structures of the
cancellous bone at the
distal femur and the fourth
lumbar vertebra, so that the myricetrin can improve the bone micro-structure by inhibiting
oxidative stress and exerting the effect of preventing and treating
osteoporosis.