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Application of gastrodin for preventing and treating osteoporosis

A technology of osteoporosis and gastrodin, which is applied in the direction of medical preparations containing active ingredients, bone diseases, plant raw materials, etc., can solve the problems of damaging cell structure and function, so as to increase the rate of bone formation, improve bone microstructure, Effect of improving oxidative stress state

Inactive Publication Date: 2014-11-05
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, high concentrations of ROS can lead to oxidation reactions of nucleic acids, proteins, and lipids, damage the structure and function of cells, and cause diseases

Method used

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  • Application of gastrodin for preventing and treating osteoporosis
  • Application of gastrodin for preventing and treating osteoporosis
  • Application of gastrodin for preventing and treating osteoporosis

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Embodiment Construction

[0032] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, which are explanations rather than limitations of the present invention.

[0033] MC3T3-E1 is an osteoblast precursor cell line that can differentiate into osteoblasts, and is a more commonly used cell model for studying the growth and differentiation of osteoblasts. Hydrogen peroxide (H 2 o 2 ) treatment is also a commonly used in vitro oxidative stress model. In order to observe the effect of gastrodin on osteoblast apoptosis and differentiation, and its anti-oxidative damage, MC3T3-E1 was selected as the cell model. H 2 o 2 Treated as an in vitro model of oxidative stress. As an animal model, the ovariectomized (castrated) mouse model is commonly used to simulate postmenopausal osteoporosis in women.

[0034] 1. Protective effect of gastrodin on MC3T3-E1 apoptosis induced by oxidative stress

[0035] 1.1 Toxic effect of pure gastrodin on cells

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Abstract

The invention discloses an application of gastrodin for preventing and treating osteoporosis, gastrodin has nontoxic effect to osteoblast precursor cells, and has no influence on cell proliferation; gastrodin has protection effect on apoptosis of MC3T3-E1 caused by hydrogen peroxide; improves oxidative stress state induced by H2O2 in a differentiation process of the MC3T3-E1, and has protective function on MC3T3-E1 osteogenic differentiation inhibition caused by H2O2; besides, gastrodin can inhibit expression of a bone absorption factor. Therefore, gastrodin can play a role of protecting osteoporosis through improvement on osteoblast apoptosis and differentiation inhibition, and indirect inhibition of osteoclast activation. In an osteoporosis model of castrated mice, gastrodin can improve oxidative stress state in serum, improves a bone micro-structure of cancellous bone of distal femur and lumbar vertebra, and increases osteogenesis rate of distal femur, so that gastrodin can improve bone micro-structure by inhibiting the oxidative stress state and has the effect for preventing and treating osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of prevention and treatment of osteoporosis, and relates to the application of gastrodin in the prevention and treatment of osteoporosis. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a degenerative, systemic, and metabolic bone disease. It is caused by a variety of causes of bone tissue loss, structural changes, and biomechanical decline. It is prone to fractures and poses a serious threat to middle-aged and elderly people. people's physical and mental health. [0003] Oxidative stress is a state in which highly active substances such as ROS (Reactive oxygen species) are produced excessively in the body, which exceeds the body's ability to remove them, resulting in an imbalance between oxidation and anti-oxidation. ROS in the physiological range play an important role in regulating normal functions of the human body, such as cell apoptosis, gene expression, and signal transduction. Howe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K36/8988A61P19/10A61P19/08
Inventor 孟国林黄强高博杨柳罗卓荆
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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