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Health-care food composition for increasing bone mass and inhibiting bone loss, and application of health-care food composition

A technology of health food and composition, applied in the direction of application, baked food, drug combination, etc., can solve the problems of family and social burden, prone to fractures, etc., and achieve the effects of reducing bone loss, increasing bone mass, and increasing bone density

Pending Publication Date: 2020-02-11
浙江欧谱生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Osteoporosis is harmful to human health in many ways, such as causing back pain, shortness and hunchback, which affects the quality of life, but the biggest harm is prone to fractures, which brings a heavy burden to the family and society

Method used

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  • Health-care food composition for increasing bone mass and inhibiting bone loss, and application of health-care food composition
  • Health-care food composition for increasing bone mass and inhibiting bone loss, and application of health-care food composition
  • Health-care food composition for increasing bone mass and inhibiting bone loss, and application of health-care food composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] To study the effect of BB diet on bone formation, we fed 21-day-old male and female Sprague-Dawley rats with AIN-93G diet with or without 10% BB powder for 14 or 40 days, and then evaluated body growth conditions and skeletal changes. The monitoring results showed that there was no significant difference in weight gain among the groups ( figure 1 ), indicating that the BB diet had no effect on body weight.

[0034] To assess differences in bone mass between groups, the left tibia was scanned with pQCT immediately after euthanasia. The study found that after 34 days of BB diet, the amount of trabecular bone in the bone increased significantly, and the bone volume and the number of osteoblasts increased significantly compared with the control group. However, compared with the control group, the number of osteoclasts was significantly inhibited ( figure 2 ).

[0035] Further studies showed that weaning rats on the BB diet for 34 days showed increases in bone mass, inc...

Embodiment 2

[0038] To determine whether the BB diet had a positive effect on the physiological state at the skeletal cellular level, we performed histomorphometric analysis of the bones of male and female rats at 34 and 61 days of age. There was no significant difference in the overall development of the skeleton between the two groups. Long bone sections showed no significant changes in the growth plate. Compared with the control group, at 34 days of age, BB diet-fed female rats had a 30% increase in trabecular bone volume, while BB diet-fed male rats had a 50% increase in trabecular bone volume (p Figure 5 A). At 61 days, both males and females had a 50% increase in trabecular bone volume (p Figure 5 A). The increase in the number of trabeculae was similar to the increase in bone volume. Supplementing the BB diet was associated with increased osteoblast numbers, bone formation rate (BFR) and mineral attachment rate (p Figure 5 A). Rats fed a BB-supplemented diet had a decreased numbe...

Embodiment 3

[0042] Using an animal model of osteoporosis, rats were treated from post-weaning day 20 to postpartum day 34, with a short-term blueberry diet group for 14 days, and then switched to a control diet and ovariectomized. The long-term blueberry diet group adopted a blueberry diet throughout the experiment. The serial tibia sections of each rat were scanned by blind method. Data analysis were taken from slice 3 and slice 4 (mean), parameters were from pQCT analysis. Static and dynamic histomorphological parameters of female rats after OVX were collected. Tissue sections of proximal tibia were stained with VonKossa, one for each group, Von Kossa staining showed double labeling of osteocalcin. The results show that a sustained, early, short-term blueberry diet can prevent bone loss.

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Abstract

The invention discloses a health-care food composition for increasing the bone mass and inhibiting the bone loss. The health-care food composition is prepared from auxiliary materials and an effectivecomponent, and the effective component is blueberries. Formulas of different proportions are adopted according to people of different ages, through the product, the bone mass is increased, increasingof the bone volume is promoted, osteoblast proliferation and differentiation are promoted, osteoclast proliferation and differentiation are inhibited, the bone loss in an osteoporosis model is reduced, and thus the health-care food composition is used for preventing and treating osteoporosis.

Description

technical field [0001] This patent belongs to the field of health food, and specifically relates to a health food composition for increasing bone mass and inhibiting bone loss and its application. Background technique [0002] Osteoporosis (OP) refers to a systemic bone disease characterized by increased bone tissue fragility, decreased bone strength, and increased fracture risk due to low bone mass and destruction of bone microstructure. Osteoporosis has become a major disease that plagues the elderly, and its incidence rate has jumped to the third place among diseases of the elderly after diabetes and senile dementia. Osteoporosis is harmful to human health in many ways, such as causing back pain, shortness and hunchback, which affects the quality of life, but the biggest harm is prone to fractures, which brings a heavy burden to families and society. On October 19, 2018, the National Health Commission publicly released the results of the first epidemiological survey of o...

Claims

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Application Information

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IPC IPC(8): A23G3/48A23G3/44A23G3/36A23G3/42A23G3/40A23L33/10A23L33/17A23L33/175A23L33/125A23L33/115A23L33/16A23L33/15A21D13/04A21D13/06A21D13/062A21D13/064A21D13/068A21D13/80A61K36/45A61P19/10
CPCA23G3/48A23G3/44A23G3/36A23G3/42A23G3/40A23G3/362A23G3/368A23L33/10A23L33/17A23L33/175A23L33/125A23L33/115A23L33/16A23L33/15A21D13/04A21D13/06A21D13/062A21D13/068A21D13/064A21D13/80A61K36/45A61P19/10A23V2002/00A23V2200/306
Inventor 陈尽染
Owner 浙江欧谱生物科技有限公司
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