The invention discloses a preparation method of multi-taste Maotai-flavor white spirit. Eleven flavor types of white spirits are taken as seasoning liquors, the preparation method is characterized by comprising the following steps of: finishing and soaking grains; cooking, gelatinizing and mixing with Luzhou-flavor white spirit fermented grains and Maotai-flavor white spirit fermented grains; spreading out and airing, stirring distiller's yeast, adding Maotai-flavor ending liquor, Luzhou-flavor yellow wine, Maotai-flavor fermented grains and Maotai-flavor yeast, and accumulating and fermenting; fermenting in a cellar, and spraying mixed solution of the Maotai-flavor ending liquor and the Luzhou-flavor yellow wine on the surface of each distilled grain layer; making sand and adding the Luzhou-flavor white spirit fermented grains, cooking and gelatinizing, then adding the Maotai-flavor ending liquor, the Luzhou-flavor yellow wine, the Maotai-flavor fermented grains and the Maotai-flavoryeast, accumulating and fermenting, and storing in the cellar and spraying the mixed solution of the Maotai-flavor ending liquor and the Luzhou-flavor yellow wine on each distilled grain layer; steaming by using a rice steamer to obtain unblended wine in rounds of 1, 2, 3, 4, 5, 6 and 7, and the wine in the seven rounds are combined according to taste and-flavor characteristics, so as to obtain combined Maotai-flavor unblended wine; and then blending the combined unblended wine with flavoring liquor, thus obtaining the multi-taste Maotai-flavor white spirit. The preparation method disclosed by the invention has the advantages of enriching-flavor of Maotai-flavor white spirit, meeting market demand and promoting development of the Maotai-flavor white spirit.