The invention discloses a
docetaxel freeze-dried
microemulsion preparation and a preparation method thereof. The
docetaxel freeze-dried
microemulsion preparation comprises the following raw materials by weight: 0.05-5 parts of
docetaxel, 0.1-40 parts of an
oil phase, 5-30 parts of a surfactant, 0-40 parts of a cosurfactant, 5-85 parts of a hydrophilic phase, 0-15 parts of a cosolvent, 0-5 parts of an
antioxidant, and 1-40 parts of a freeze-
drying protective agent. Specifically, the surfactant is one or several of
polyethylene glycol-8-caprylin / caprin,
polyoxyethylene castor oil, polyoxyethylene hydrogenated
castor oil,
poloxamer,
polyethylene glycol-12-hydroxystearate,
polyethylene glycol stearate 15 and
sorbitan monooleate. The preparation method includes: preparing the raw materials into a
microemulsion according to the ratio, and then conducting freeze-
drying. Before clinical use, the docetaxel freeze-dried microemulsion preparation has no need for a tedious two-step
dilution process, after redissolving, the docetaxel freeze-dried microemulsion preparation can be subjected to intravenous injection, and has no vascular
irritation and small
allergic reaction. Hemolytic experiments show that the docetaxel freeze-dried microemulsion preparation does not generate
hemolysis.