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Pharmaceutical composition for treating bone diseases, injection thereof and preparation methods thereof

A composition and bone disease technology, applied in drug combination, bone disease, drug delivery, etc., can solve the problem of inability to extract active ingredients from pig limb bones and melon seeds, limit the application of bone melon extract injections, and poor dissolution of active ingredients, etc. problem, to achieve the effect of non-toxic side effects, reduced content, mild acidity and alkalinity

Active Publication Date: 2014-11-05
哈尔滨圣泰生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Bone diseases are common clinical diseases, mainly including rheumatoid arthritis, degenerative osteoarthritis, ankylosing spondylitis, lumbar disc herniation, gout and osteoporosis, etc. These common bone diseases have plagued patients for a long time and are difficult to cure. Easy to relapse, causing great pain to patients
[0003] Bone melon extract is a drug made from the dried and mature seeds of pig limb bones and melons. It mainly contains the following components: polypeptide bone metabolism factors, melon seed extract, various free amino acids, and organic calcium and inorganic calcium. , phosphorus ions, inorganic salts and trace elements; because this product contains a variety of active peptides for bone metabolism, it can regulate bone metabolism, stimulate osteoblast proliferation, promote new bone formation, regulate calcium and phosphorus metabolism, and increase bone metabolism. Calcium deposition, prevention and treatment of osteoporosis, anti-inflammatory and analgesic effects, often used to treat bone diseases such as rheumatoid arthritis; but the curative effect of the bone melon extract on gout is not significant
[0004] Secondly, the current preparation methods of bone melon extract are all using conventional extraction, water precipitation, acid-base precipitation and other processes, which cannot fully extract the active ingredients in pig limb bones and melon seeds
[0005] In addition, the injections prepared from the extracts of the bone melon have problems such as poor stability and poor dissolution of active ingredients, which limit the application of the injections of the extracts of the bone melon

Method used

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  • Pharmaceutical composition for treating bone diseases, injection thereof and preparation methods thereof
  • Pharmaceutical composition for treating bone diseases, injection thereof and preparation methods thereof
  • Pharmaceutical composition for treating bone diseases, injection thereof and preparation methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] A pharmaceutical composition for treating bone diseases, the pharmaceutical composition consists of the following components by weight:

[0075] Pig limb bone extract 30 Melon seed extract 15

[0076] Preparation:

[0077] 1) Preparation of pig limb bone extract:

[0078] 1.1 Broken: Wash the raw pig limb bones until no foreign matter is visible to the naked eye, and then crush them;

[0079] 1.2 Extraction: Put the broken pig limb bones into the extraction tank, add purified water, and extract twice by hot pressing. The amount of purified water added each time is twice the weight of the raw material, and each time is 1h. 121°C to obtain the extract;

[0080] 1.3 Concentration: Put the extract into the settling tank through the material pump, cool down to 30°C, let it stand still until the oil comes out, concentrate the extract after deoiling in a single-effect concentrator, and control the vacuum degree during concentration. -0.05Mpa, the temperature is controlled ...

Embodiment 2

[0099] A pharmaceutical composition for treating bone diseases, the pharmaceutical composition consists of the following components by weight:

[0100] Pig limb bone extract 60 Melon seed extract 22.5

[0101] Preparation method: prepared according to the method of Example 1.

Embodiment 3

[0103] A pharmaceutical composition for treating bone diseases, the pharmaceutical composition consists of the following components by weight:

[0104] Pig Limb Bone Extract 50 Melon Seed Extract 30

[0105] Preparation method: prepared according to the method of Example 1.

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Abstract

The invention relates to a pharmaceutical composition for treating bone diseases, an injection thereof and preparation methods thereof. The pharmaceutical composition is composed of an extraction liquid of pig four limbs and a melon seed extraction liquid. Further, the pharmaceutical composition is added with mixed extraction liquids respectively prepared from commen bomhax flower, flos buddlejae and herba eupatorii. The prepared pharmaceutical composition has substantially improved treatment effect on rheumatoid arthritis, degenerative osteoarthritis, ankylosing spondylitis, sciatica, lumbar disc herniation and other bone diseases, is improved in treatment effect on gout and has no toxic and side effects. Additionally, the provided injection has extremely high stability and is substantial in effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating bone diseases, an injection and a preparation method thereof. Background technique [0002] Bone diseases are common clinical diseases, mainly including rheumatoid arthritis, degenerative osteoarthritis, ankylosing spondylitis, lumbar disc herniation, gout and osteoporosis, etc. These common bone diseases have plagued patients for a long time and are difficult to cure. Easy to relapse, bring great misery to the patient. [0003] Bone melon extract is a drug made from the dried and mature seeds of pig limb bones and melons. It mainly contains the following components: polypeptide bone metabolism factors, melon seed extract, various free amino acids, and organic calcium and inorganic calcium. , phosphorus ions, inorganic salts and trace elements; because this product contains a variety of active peptides for bone met...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61K36/56A61K9/08A61P29/00A61P19/08A61P19/02A61P25/02A61P19/06A61K35/32
Inventor 宋洋
Owner 哈尔滨圣泰生物制药有限公司
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