Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition of voriconazole phosphate for injection or pharmaceutically acceptable salt thereof and preparation method thereof

A technology for voriconazole phosphate and medicinal salts, applied in the field of medicine, can solve problems such as loss, fracture, renal dysfunction, etc., and achieve the effects of easy operation, good appearance and stable performance

Active Publication Date: 2014-10-29
HC SYNTHETIC PHARMA CO LTD
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Then there are significant changes in organelles, such as mitochondrial swelling and deformation, cells at the base of the Golgi apparatus and smooth endoplasmic reticulum, and irreversible rupture of intercellular tight junctions, which directly lead to decline or even loss of renal function

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition of voriconazole phosphate for injection or pharmaceutically acceptable salt thereof and preparation method thereof
  • Composition of voriconazole phosphate for injection or pharmaceutically acceptable salt thereof and preparation method thereof
  • Composition of voriconazole phosphate for injection or pharmaceutically acceptable salt thereof and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the preparation of voriconazole phosphate for injection

[0020] Prescription: Voriconazole Phosphate 200g

[0021] Water for injection 2000ml

[0022] __________________________________

[0023] Makes 1000 bottles

[0024] Add 1500ml of water for injection into the liquid preparation container, add the exact prescription amount of voriconazole phosphate, stir to dissolve, slowly add sodium hydroxide, adjust the pH to 8.0, add water to the full amount, and then add 0.05% (W / V) The medicinal charcoal was stirred for 60 minutes, decarbonized by coarse filtration with a sand filter rod, and finely filtered with a 0.22 μm microporous membrane until the clarity was qualified; after the content of the intermediate was determined to be qualified, the fixed amount was packed in vials, Add half stopper, decarburize the sample by coarse filtration with a sand filter rod, and fine filter it with a 0.22 μm microporous membrane until the clarity is qualified; after ...

Embodiment 2

[0025] Embodiment 2: the preparation of voriconazole disodium phosphate for injection

[0026] Prescription: Voriconazole Disodium Phosphate 200g

[0027] Water for injection 2000ml

[0028] __________________________________

[0029] Makes 1000 bottles

[0030] Add 1500ml of water for injection into the liquid preparation container, add voriconazole phosphate disodium phosphate in the exact prescribed amount, stir to dissolve, slowly add acetic acid, adjust the pH to 8.5, add water to the full amount, and then add 0.05% (W / V) The medicinal charcoal was stirred for 60 minutes, decarbonized by coarse filtration with a sand filter rod, and finely filtered with a 0.22 μm microporous membrane until the clarity was qualified; after the content of the intermediate was determined to be qualified, the fixed amount was packed in vials, Add a half stopper, decarburize the sample by coarse filtration with a sand filter rod, and fine filter with a 0.22 μm microporous membrane until the...

Embodiment 3

[0031] Embodiment 3: the preparation of voriconazole phosphate for injection

[0032] Prescription: Voriconazole Phosphate 200g

[0033] Mannitol 2g

[0034] Water for injection 2500ml

[0035] __________________________________

[0036] Makes 1000 bottles

[0037] Add 2000ml of water for injection in the liquid preparation container, add voriconazole phosphate of accurate prescription amount, under stirring of 2 g of mannitol, slowly add sodium bicarbonate, adjust pH to 7.8, add water to full amount, then add 0.05% (W / V) medicinal charcoal, stirred for 60 minutes, decarbonized by coarse filtration with a sand filter rod, and finely filtered with a 0.22 μm microporous membrane until the clarity is qualified; after the determination of the intermediate content is qualified, the fixed amount is packed in vials In the medium, add half stopper, decarburize the sample by coarse filtration with a sand filter rod, and fine filter with a 0.22 μm microporous membrane until the cla...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides voriconazole phosphate ester for injection and a medicinal salt thereof and a preparation method for the voriconazole phosphate ester for injection and the medicinal salt thereof. The preparation method comprises the following steps: adding 5 to 98 percent water for injection in a liquid preparation container; adding 90 to 110 percent of the accurate formula dosage of voriconazole phosphate ester and the medicinal salt thereof in the container; stirring the mixture; slowly dropwise adding a pH value regulator; regulating pH to between 6.0 and 11; supplementing water to the full dosage and then adding 0.01 to 1.0 percent (weight in volume) medicinal carbon into the product; stirring the mixture for 15 to 60 minutes; using a sand filter stick to carry out rough filtration and decarburization on the obtained product, and using a 0.22mum millipore filter to carry out fine filtration on the product until the clarity is qualified; after determining that the content of the midbody is qualified, determining the filling quantity and subpackaging the finished product in the vial; adding the semi-plug; carrying out freezing and drying on the sample; controlling the moisture content between 1 and 8 percent; pressing the plug; and carrying out capping.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to a composition of voriconazole phosphate for injection or a medicinal salt thereof and a preparation method thereof. technical background: [0002] Voriconazole is a broad-spectrum triazole antifungal drug indicated for the following: treatment of invasive aspergillosis. Treatment of severe invasive infections caused by fluconazole-resistant Candida species (including Candida krusei). Treatment of serious infections caused by Actinomycetes and Fusarium species. This product should be used primarily for the treatment of progressive, potentially life-threatening infections in immunocompromised patients. The prodrug of voriconazole phosphate voriconazole can be rapidly hydrolyzed into voriconazole in the body to take effect. Since voriconazole has very little water solubility, a method of encapsulating voriconazole with hydroxypropyl-β-cyclodextrin is used to solubilize voriconazo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K31/506A61K47/02A61K47/12A61K47/18A61P31/10
Inventor 杨成
Owner HC SYNTHETIC PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com