A method for synthesizing a 2-position arylpyrido[2, 3-d]
pyrimidine derivative comprises the following steps: firstly, dissolving 3-aminomethylpyridin-2-amine and
aryl aldehyde in
acetonitrile, and then adding
cuprous chloride, 2, 2, 6, 6-tetramethylpiperidin-1-
oxide free radical and triethylene
diamine into a reaction solution in an
oxygen atmosphere, refluxing till the completion of a reaction,removing a
solvent, and performing thin-layer
chromatographic separation on a residue to obtain a 2-substituted pyrido[2, 3-d]
pyrimidine. The method has the advantages as follows: 1), the preparation of a catalyst is simple and high in efficiency; 2), the catalyst does not contain precious metals, is low in price, and has very high
chemical stability; 3), the catalytic process is good in selectivity, free of other side reactions, high in efficiency and environment-friendly; the operation is convenient, the cost is low, the yield is high,
mass synthesis can be performed, and the method is applicable to industrial production.