The invention discloses an LC oscillator magnetosensitive biosensor based on the on-chip switched capacitor in-situ self-calibration technology, which belongs to the technical field of biosensors. The sensor includes: n LC oscillator sensing units on a CMOS chip, n LC oscillator in-situ self-calibration switch capacitor, power management module, buffer, encoder / decoder, mixer, low-pass filter, and off-chip frequency counter; among them, n switch capacitors and n LC oscillators Sensor sensing units form a sensor microarray, n is a positive integer; the output of each LC oscillator sensing unit is connected to a switched capacitor. On the basis of achieving a good noise suppression effect, the chip area is saved, the cost and complexity are reduced, and the detection sensitivity is improved. After tape-out experiments, all indicators of biochips using this in-situ calibration technology have reached the highest level of similar technologies.