82results about How to "Lower LDL" patented technology

The invention relates to a multi-functional health care soy sauce and a preparation method thereof. The soy sauce comprises the following main components by mass percentage: 10%-20% of potato, 10%-15% of sweet potato, 2%-5% of formosan lattuce herb, 3%-6% of lotus nut, 2%-5% of lalang grass rhizome, 3%-6% of hawthorn, 2%-5% of purslane, 1%-3% of citric acid, 1%-3% of eggshell, 1%-3% of sorbic acid, 1%-3% of donkey-hide gelatin, 1%-3% of gastrodia elata, 1%-3% of bezoar, 1%-2% of Chinese yam and water. The health care soy sauce has remarkable effects for treating and preventing constipation and anemia, and simultaneously has an effect of reducing blood pressure and blood fat to a certain extent.

A composition containing EPA and EHA, preferably derived from fish oil, in combination with at least one of oleuropein, allicin, and policosanol having anti-inflammatory, anti-thrombotic, immunomodulatory activity as well as activity to lower triglycerides and low density lipoprotein, to increase high density lipoprotein, and to lower both systolic and diastolic blood pressure.

The present invention is directed to a novel methods and compositions for the therapeutic intervention of vascular complications associated with diabetes, hyperlipidemias, and various cardiovascular disorders including but not limited to recalcitrant hypertension, coronary artery disease, pulmonary arterial hypertension, congestive heart failure, and hemolytic anemias. More specifically, the specification describes methods and compositions for treating such vascular disorders using compositions comprising BH4 and derivative thereof. Combination therapies of BH4 and other therapeutic regimens are contemplated.

The invention provides application of theaflavin as a feed additive and corresponding feed, belonging to the technical field of feed additives. The first purpose of the invention is to provide an application of the theaflavin as a feed additive, and the use method is that the weight of the theaflavin is added according to the total weight of the feed, namely, being 0.015-0.045% of the total weight. The second purpose of the invention is to provides a feed using the theaflavin as the feed additive. The feed comprises the components of fish meal, bean pulp, peanut meal, cuttlefish cream, beer yeast, shrimp shell powder, fish oil, soya-bean oil, choline chloride, soyabean lecithin, monocalcium phosphate, vitamin premix, high gluten flour and theaflavin. According to invention, the theaflavin is taken as the feed additive, so that the immunocompetence of bred animals is improved, and the problems of drug residue and the like caused by using antibiotics are avoided; and the oxidation resistance of the bred animals can be improved, so that the toxic and side effects caused by adding chemosynthesis antioxidant are avoided. Theaflavin can be widely used in feed additives.

The invention provides compounds of Formula I:wherein R1, R2, R3, R4, R6, R7, R8, and A are as defined. Compounds of formula I have activity inhibiting production of Aβ-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.

A method of treating cholesterol imbalance, high LDLs, and other metabolic syndrome problems and symptoms of osteoarthritis. The regimen preferred embodiment includes lipids as 60% or more of daily caloric content, protein up to 10%-15% of daily caloric content; and carbohydrates up to 25% or less of daily caloric content, primarily in the form of non-starchy, low-glycemic fresh fruit and vegetables, and nuts, along with a daily intake of 35 grams of dietary fiber, with a significant percentage of this as soluble fiber; average daily cholesterol intake of less than 10 mg, and 30 grams of cocoa solids.

The invention relates to health-care sauce which is characterized by comprising the following main components as per mass percentage: 10-20% of Chinese yams, 10-15% of rapeseeds, 3-5% of folium artemisiae argyi, 3-6% of walnut meat, 2-5% of polygonum multiflorum, 3-6% of agaric, 2-5% of astragalus membranaceus, 1-3% of ganoderma, 1-2% of sodium hydroxide, 1-2% of calcium propionate, 1-4% of alcohol, 1-3% of Chinese-dates, 1-3% of lotus seeds, 1-3% of Ligusticum chuanxiong Hort, and the balance of water. According to the invention, the health-care sauce has the function of preventing and curing diseases under the premise that the normal seasoning function is guaranteed, particularly has remarkable effect on curing and preventing anaemia and malnutrition, and can improve the immunity of human body.

The present invention provides an excellent medicinal composition for lowering blood lipid level. The medicinal composition containing an HMG-CoA reductase inhibitor and bile acids.

The invention relates to the technical field of antibody engineering and specifically discloses an anti-PCSK9 monoclonal antibody. The invention comprises an amino acid sequence coding an antibody variable region and a CDR region as well as an acquisition method and an application of the monoclonal antibody. The monoclonal antibody disclosed by the invention is prepared by the following steps: screening out anti-PCSK9 monoclonal antibodies from a phage library; performing affinity maturation by a method of establishing phage library through strand displacement; screening the mutant libraries of light-chain CDR1, 2, and 3 regions of the monoclonal antibody obtained by primary screening, and selecting the monoclonal antibodies with relatively high affinity; and screening the mutant libraries of heavy-chain CDR1, 2, and 3 to finally obtain the anti-PCSK9 monoclonal antibody with high affinity. In the invention, the obtained PCSK9 antibody has good affinity on PCSK9 and can inhibit combination of the PCSK9 with ligand thereof and can be used for treating dyslipidemia, cardiovascular and cerebrovascular diseases and thrombosis-obstructive diseases.

The invention discloses a compound gingko health product solid preparation which is prepared by mixing ginkgo leaf extract, salvia miltiorrhiza bunge, American ginseng, seabuckthorn flavone and gelatin or an enteric substrate. The compound gingko health product solid preparation comprises the following effective components in parts by weight: 1-60 parts of ginkgo leaf extract, 1-60 parts of salvia miltiorrhiza bunge, 1-30 parts of American ginseng and 0.5-20 parts of seabuckthorn flavone. The gingko, the salvia miltiorrhiza bunge, the American ginseng and the seabuckthorn flavone are comprehensively mixed to achieve the effects of convenient use and comprehensive nourishing. The health product of the compound gingko health product solid preparation has values as both food and medicine and can be used by a patient with a cerebral-vascular disease and a patient with higher blood fat and used for resisting cancer, resisting fatigue, resisting anoxia, resisting radiation, resisting aging, strengthening immunity, and the like by a healthy person. The compound gingko health product solid preparation mainly has two formulations of pills and soft capsules, is convenient for use, is beneficial to absorption and meets the requirement on health by wide consumers.

The invention discloses a lactobacillus probiotic strain. The preservation number of the strain is CGMCC NO. 12422, and the preservation date is May, 6th, 2016. The 16S rRNA sequence of the strain is shown as SEQ ID NO: 2. The invention also discloses an application of the strain in preparing a lipid-lowering drug, food and a healthcare product. The strain is harmless to animals and has effects of regulating and lowering blood fat.

The invention relates to the technical field of biology, in particular to dendrobium officinale and a dendrobium officinale extract combined probiotics for regulating blood sugar and blood fat, and improving diabetes and metabolic syndrome and alleviating occurrence of related complications so as to maintain metabolic stability of organisms. The dendrobium officinale has the effects of regulatingand controlling blood sugar, enhancing body immunity and the like; the probiotics is an active microorganism beneficial to a host, can regulate intestinal flora balance, and can generate an exact health effect so as to improve the micro-ecological balance of the host and play a beneficial role. According to the invention, the dendrobium officinale exerts the effects of reducing blood sugar and blood fat, prebiotics can promote the growth of probiotics and regulate glucose uptake and improve the gastrointestinal irritation caused by taking the probiotics alone, so that the probiotics and dendrobium officinale can better play the role in reducing blood sugar, complications are reduced, and a pharmaceutical composition for preventing or treating diabetes mellitus and metabolic syndromes can be prepared by the probiotics and dendrobium officinale. Therefore, the product provides a new application for improving diabetes and metabolic syndrome related diseases.

The invention relates to the technical field of antibody engineering and in particular discloses a PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) resistant monoclonal antibody. The monoclonal antibody disclosed by the invention comprises an amino acid sequence coding an antibody variable region and a CDR region. The invention further discloses an acquiring method and application of the monoclonal antibody. The method comprises the following steps: screening a PCSK9 resistant monoclonal antibody from a phage antibody library, performing affinity maturation through a method for constructing the phage antibody library by virtue of strand displacement, performing mutant library-construction screening on light-chain CDR1, 2 and 3 regions of the monoclonal antibody obtained by preliminaryscreening, selecting a monoclonal antibody with high affinity, performing mutant library-construction screening on heavy-chain CDR1, 2 and 3 regions of the monoclonal antibody, and finally screeningthe PCSK9 resistant monoclonal antibody with high affinity. The PCSK9 resistant monoclonal antibody obtained in the invention has excellent affinity to PCSK9, is capable of inhibiting binding betweenthe PCSK9 and ligands thereof, and can be used for treating dyslipidemia, cardiovascular and cerebrovascular diseases and thrombosis-obstructive diseases.

Dicot, and especially Brassicaceae sprout preparations are employed as a dietary agents that significantly reduce oxidized species in human serum. In one especially preferred aspect, contemplated compositions are employed to reduce serum oxLDL and to increase serum HDL levels.

The invention discloses a medicine for treating liver cancer. The medicine comprises the following Chinese herbal medicines of virgate wormwood herb, szechwan chinaberry fruit, cassia seed, tuber fleeceflower root, leech, ginseng, hawthorn fruit and the like in a weight ratio. According to the medicine, the effective rate of treating primary cancer liver in moderate and advanced stages is 76.2 percent, and tumors are stable and difficultly relapse after treatment. Experiments on hearts, livers, spleens, lungs and kidneys of animals are performed within the range of treatment dose, and the toxic or side effects are not obvious.

The invention provides edible oil without saturated fatty acid. The edible oil is characterized by comprising the following main ingredients by weight percentage: 75 to 90 percent of vegetable-oil acid, 8 to 20 percent of linoleic acid, and 2 to 5 percent of linolenic acid. The edible oil without the saturated fatty acid has the advantages of the following physiological functions: reducing serum cholesterase, triglyceride and low density lipoprotein, reducing blood viscosity, preventing formation of thrombus, promoting insulin beta-cell to secrete insulin, resisting the sensibility of a receptor to the insulin, providing strong functions of anticoagulation and hemangiectasis through transforming the edible oil into a precursor substance of male prostaglandin, namely prostacyclin, providing the edible oil without saturated fatty acid indispensable to a human body, playing certain effect in preventing high blood pressure, high blood fat, coronary heart disease and thrombosis and diabetes, synthesizing ficosapentenoic acid and docosahexenoic acid through reacting with relevant enzyme, and further playing roles in reducing blood fat and the like of the edible oil.

The invention discloses a feed special for raising fat liver ducks. The feed consists of the following components in percentage by weight: 97.75 percent of corn, 0.35 percent of table salt, 0.45 percent of mountain flour, 0.80 percent of calcium hydrophosphate, 0.50 percent of premix and 0.15 percent of astragalus. A preparation method for the feed comprises the following steps of: crushing the corn into powder with the diameter of less than or equal to 1mm by using a crushing machine, adding other various materials in the proportion (the astragalus is also crushed into powder and added), mixing the materials, fully blending, and quantitatively packaging. The invention has the advantages that: a fat liver is health-care food for preventing cardiovascular disease and strengthening brain; without residue of harmful chemical components, the fat liver can be safely and reliably eaten; and the product has a high added value, a broad market prospect and a remarkable benefit.

The invention provides a weight-losing composition containing bacillus subtilis and a preparing method and application of the weight-losing composition. The weight-losing composition is prepared fromthe following components in percentage by mass: 70-80% of the bacillus subtilis, 20-30% of soybean meal, 5-10% of glucose, and 0.1-0.15% of dipotassium phosphate, wherein the sum of the percentage ofthe weight-losing composition does not exceed 100%. According to the weight-losing composition, probiotics and dietary fibers are combined, the screened bacillus subtilis serves as a main ingredient and is mutually synergistic with the soybean meal, the glucose and the dipotassium phosphate according to the specific proportion, the obvious weight-losing effect is achieved, the blood fat content ofobese mice is significantly decreased, a formula is concise, the toxic and side effects are avoided, and the wide application prospects are achieved.

The present invention relates to a process for producing eggs with low cholesterol level. Different concentrations of fermented red mold rice are added to hens feeds. The fermented red mold rice contains Monacolin K, which has an effect on reducing cholesterol level. The cholesterol level in eggs produced by the present process is much lower than that in eggs produced by the prior art process. Furthermore, the serum triglyceride of hens is reduced. People are paying more attention to health, thus lowering consumption of high cholesterol food. Since cholesterol in eggs accounts for more than 50% of daily take-up, consumption of egg can hardly increase. Therefore, low cholesterol eggs can not only be beneficial to the public's health, but also bears business advantage.

A related production method for a liquid curing material with abundant nutrition is characterized in that the curing material comprises the main compositions in percent by mass: 10-20% of carrot, 10-15% of five-spice powder, 1-3% of folium artemisiae argyi, 1-2% of walnut kernel, 1-2% of laver, 2-4% of auricularia auricula, 2-5% of sea-tangle, 1-3% of haw, 40-50% of salt, 1-3% of jujube, 1-3% of lotus seed, 1-3% of rhizoma chuanxiong, and the balance water.

Hazelnut table vinegar is provided. The hazelnut table vinegar is a product obtained by adopting hazelnut kernel as a raw material and by steps of roasting, pulping, saccharifying, fermenting by alcohol and acetic acid, and sterilizing. Preparation of the hazelnut table vinegar includes steps of: treating the raw material, pulping, evaporating the raw material at normal pressure, performing size mixing, saccharifying, preparing a mixed liquor liquid, fermenting by alcohol, inoculating acetic bacteria, preparing grains and adding into a tank, fermenting by acetic acid, adding salt, curing, dipping and spraying, sterilizing, and clarifying to obtain a hazelnut table vinegar finished product. The hazelnut table vinegar is table vinegar and maintains original nutrients of hazelnut. The hazelnut table vinegar has functions of strengthening the spleen and the stomach, tonifying the liver, improving eyesight, boosting body activity functions, and the like, has high nutrition and an anti-ageing function, and is organic healthy table vinegar.

The invention relates to the technical field of biology, in particular to application of probiotics, which is combined with a phyllanthus emblica xtract in regulating blood sugar and blood fat, improving diabetes and metabolic syndrome, slowing down occurrence of related complications and further maintaining metabolic stability of organisms. The probiotics is an active microorganism beneficial toa host, can regulate intestinal flora balance, and can generate an exact health effect so as to improve the micro-ecological balance of the host and play a beneficial role; the phyllanthus emblica hasthe effects of regulating blood sugar, enhancing body immunity and the like. The phyllanthus emblica is found to play a role in reducing blood sugar and blood fat; the phyllanthus emblica component can provide a good environment for the growth of probiotics; meanwhile, the probiotics are promoted to regulate glucose uptake, and the gastrointestinal tract stimulation effect generated by taking theprobiotics alone is improved, so that the probiotics and the phyllanthus emblica can better play a role in reducing blood sugar, complications are reduced, and the material can be prepared into a pharmaceutical composition for preventing or treating diabetes and metabolic syndrome. Therefore, the invention provides a new application for improving diabetes and metabolic syndrome related diseases.

The invention provides a compound lipid-decreasing soft capsule and a preparation method thereof. The compound lipid-decreasing soft capsule is characterized by mainly comprising the following main parts: folium ginkgo, pseudo-ginseng, gynostemma pentaphylla, red yeast rice and seabuckthorn seed oil. According to the invention, the compatibility between traditional Chinese medicines and raw materials is mainly used, so as to develop a Chinese medicinal formulae for effectively preventing and decreasing lipid, meanwhile, for overcoming defects of inconvenience in decoction, carrying and taking, incomplete decocted components, bad mouthfeel and the like in the conventional dosage form decoction at present, the decoction is prepared into modern soft capsule form achieving accurate quantification through a modern drug mean, the bioavailability is improved, the compound lipid-decreasing soft capsule is enabled to be more remarkable in effect and convenient to take, objectionable odors and bitter taste in the traditional Chinese medicines can be covered up, so as to be accepted by people easily, and the lipid-decreasing effect can be better achieved.

Provided are lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia. Lucid ganoderma and strigose hydrangea juvenile leaves serve as a culture medium, the culture medium is inoculated with Chinese caterpillar fungus strains after being sterilized, culture is carried out till mycelia grow on the whole culture medium, and then the culture medium where the mycelia grow is crushed to obtain the mycelia. By means of the mycelia, lucid ganoderma, strigose hydrangea juvenile leaves and cordyceps militaris are combined through the biotechnology to form a special combination, namely, the lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia, the formed product is special and novel, nutrition is enriched better, and the functions and the healthcare effect are more remarkable. The lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia are a novel and special healthcare product. The production and preparation process of the final product, namely, the lucid ganoderma, strigose hydrangea juvenile leaf and cordyceps militaris mycelia has the advantages of being short in culture period, simple, high and stable in product production efficiency and the like. In addition, the formed product is wide in application range, and can serve as a raw material for preparing medicine, healthcare products and special food additives. Very good market prospects are achieved, and the generated economic benefits are very remarkable.

The invention discloses a pharmaceutical composition capable of reducing hyperlipidemia and losing weight. The pharmaceutical composition comprises the following raw materials in parts by weight: 14-16 parts of ginseng, 14-16 parts of lotus leaf, 9-11 parts of balsam pear, 8-10 parts of rhizoma pinellinae praeparata, 11-13 parts of prepared rehmannia root, 18-22 parts of semen cassia, 18-22 parts of raw ossa draconis, 18-22 parts of semen coicis, 11-13 parts of rhizoma alismatis, 4-6 parts of chrysanthemum, 9-11 parts of angelica sinensis, 4-6 parts of polygonum cuspidatum, 14-16 parts of hyacinth bean, 14-16 parts of herba epimedii, 14-16 parts of root of kudzu vine and 4-6 parts of uncaria. A corresponding treatment method is adopted in term of main pathogenesis, so that low density lipoprotein of a patient is reduced, high-density lipoprotein is increased, the cholesterol is lowered, and a plurality of bitter traditional Chinese medicines are adopted, so that the appetite of the patient is lowered, and absorption of gastrointestinal tracts of the patient on grease also can be reduced.

The invention relates to dietary fabric compositions containing konjac glucomannan and their preparing process, wherein the compositions can be made into capsules or chewing tablets, and comprise konjac glucomannan 30-90 wt%, acacia gum 5-60 wt%, laminaria powder 5-10 wt%, green tea powder 1-10 wt%, and conventional food additives, such as 0-20 wt% of microcrystalline cellulose.

The invention provides a traditional Chinese medicine composition for treating fatty liver, wherein the traditional Chinese medicine composition is prepared from the following raw materials by weight: 15-45 parts of hawthorn, 25-55 parts of salvia miltiorrhiza, 9-39 parts of pericarpium citri reticulatae, 15-45 parts of codonopsis pilosula, 5-35 parts of rhizoma alismatis, 15-45 parts of pollen typhae, and 15-45 parts of radix curcumae. The invention also provides a preparation method of the traditional Chinese medicine composition and a use of the traditional Chinese medicine composition in preparation of drugs for preventing and / or treating fatty liver and hyperlipemia. The prepared traditional Chinese medicine composition has the fatty liver treating clinical total effective rate of 93.33%, has the advantages of high efficiency, low cost, convenience, safety and the like, and provides a new scheme for preventing and / or treating fatty liver and hyperlipidemia.

The invention discloses a tenacious biscuit containing red jujube residues and Kunlun chrysanthemum and a making method of the tenacious biscuit. A formula, which is optimized by tests, of the biscuitcontaining red jujube residues and Kunlun chrysanthemum comprises 1000 parts of flour, 200 parts of butter, 200 parts of xylitol, 20 parts of starch, 6 parts of salt, 6 parts of baking soda, 5 partsof ammonium bicarbonate, 10-30 parts of the red jujube residues, 2-20 parts of a Kunlun chrysanthemum water extract and 2-10 parts of sodium alginate. Meanwhile, the tenacious biscuit containing red jujube residues and Kunlun chrysanthemum is obtained through steps of pretreatment, conditioning, roll pressing, forming, baking and packing according to scientific design. Functional tests prove thatthe prepared tenacious biscuit has a remarkable effect on reduction of total cholesterol, triglyceride and low-density lipoprotein of rats, the blood fat can be reduced effectively, and experiments show that the clearance rate of the tenacious biscuit to DPPH.free radicals can reach 41.25%, and the anti-ageing effect is remarkable.

The invention relates to the technical field of biology, in particular to probiotics, which is combined with dendrobium officinale, phyllanthus emblica and the extracts to regulate blood sugar and blood fat, improve diabetes mellitus and metabolic syndrome, slow down occurrence of related complications and further maintain metabolic stability of organisms. The probiotics is an active microorganismbeneficial to a host, can regulate intestinal flora balance, and can generate an exact health effect so as to improve the micro-ecological balance of the host and play a beneficial role; the phyllanthus emblica has the effects of regulating blood sugar, enhancing body immunity and the like. The dendrobium officinale and phyllanthus emblica are found to play a role in reducing blood sugar and blood fat; the dendrobium officinale and phyllanthus emblica components can provide a good environment for the growth of probiotics; meanwhile, the probiotics are promoted to regulate glucose uptake, andthe gastrointestinal tract stimulation effect generated by taking the probiotics alone is improved, so that the probiotics and the phyllanthus emblica can better play a role in reducing blood sugar, complications are reduced, and the material can be prepared into a pharmaceutical composition for preventing or treating diabetes and metabolic syndrome. Therefore, the invention provides a new application for improving diabetes mellitus and metabolic syndrome related diseases.