Medicinal composition for lowering blood lipid level

Abstract

The present invention provides an excellent medicinal composition for lowering blood lipid level. The medicinal composition containing an HMG-CoA reductase inhibitor and bile acids.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for lowering blood lipids containing HMG-CoA reductase inhibitors and bile acids. Background technique [0002] Statins are drugs that specifically and competitively inhibit HMG-CoA reductase in vivo and lower blood cholesterol levels. [0003] In addition, the known effects of bile acid components include: improving cholestasis, dissolving cholesterol-like gallstones, inhibiting cholesterol absorption from the intestine, etc. ぅ). [0004] On the other hand, in some literatures, the combined use of statins and bile acid components is mostly about the therapy of dissolving cholesterol gallstones, and others have also reported about the bile flowing out to the duodenum due to certain reasons. Literature on the treatment of induced biliary liver disease, biliary cirrhosis, cholestatic jaundice, secondary hypercholesterolemia, etc. [0005] Examples of combined use of statins and bile acid com...

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Problems solved by technology

[0012] Concomitant use of bile acids with statins further reduces cholesterol concentrations in bile and is therefore consistent with the usefulness of gallstone-dissolving therapy, with no opposing views and data

[0013] On the other hand, in known documents that report the effect on blood lipids when statin drugs are used in combination with bile acids, the results are different from the above-mentioned evaluation.

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