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Composition of active ingredients of alisma rhizome, and medical application

A technology of active ingredient and composition, applied in the field of active ingredient composition of Alisma, can solve problems such as complex chemical composition

Inactive Publication Date: 2006-12-06
江苏省药物研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical composition of traditional Chinese medicine is extremely complex. In order to ensure the curative effect of Alisma extract, it is necessary to clarify the content of active ingredients in Alisma extract.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of herbal extract:

[0035] Method a: Take 2 kg of dry tubers of Alisma orientalis (Sam.) Juzep., a plant of the family Alismaceae, crush them, and extract twice with 4 liters of chloroform under reflux, each time for 3 hours. The extracts were combined, and the solvent was recovered to obtain 87 grams of oily extract.

[0036] Method b: take 2 kg of dried tubers of Alisma orientalis (Sam.) Juzep., and grind them, percolate with 80% ethanol, recover ethanol, and obtain 94 grams of oil.

[0037] Method c: Take the dry tuber of Alisma orientalis (Sam.) Juzep., which is a plant of the family Alismaceae, and crush it, pass through a 20-mesh sieve, weigh 4 kg of the medicinal powder, and put it in a 10L extraction barrel for supercritical carbon dioxide extraction. Extraction conditions: the pressure of carbon dioxide is 20-45MPa, extraction temperature 46-49°C, extraction time 2.5 hours, to obtain 150g of oil.

[0038] Method d: Take 1 kg of dried tuber pieces...

Embodiment 2

[0041] Preparation of alisitol B23-acetate:

[0042]Method a: Weigh 100 grams of the oily extract of Example 1, put it on a silica gel column (500 grams) and elute it with petroleum ether and ethyl acetate (10:1), then wash it with petroleum ether and ethyl acetate (10:3) Elution, 200mL as a fraction, detected by TLC, collected the target fraction, and obtained 0.8g of crystals. Recrystallization from petroleum ether-ethyl acetate gave 0.5 g of crystals. Identified as alisol B23-acetate.

[0043] Method b: Weigh 100 grams of the oily extract of Example 1, put it on an aluminum oxide (500 grams) column and wash it with petroleum ether and chloroform (20:1), and then wash it with petroleum ether and chloroform (10:1). 200mL was taken as a fraction, detected by TLC, and the target fraction was collected to obtain 0.7g of crystals. After recrystallization from methanol, 0.5 g of crystals were obtained, which were identified as alisitol B23-acetate.

Embodiment 3

[0045] Preparation of Alisitol A24-acetate:

[0046] Method a: According to the method a of Example 2, after the petroleum ether and ethyl acetate (10:3) are eluted, then eluted with petroleum ether and ethyl acetate (10:5), detected by TLC, and the target is collected Fractions obtained 0.4 g of crystals, and recrystallized from petroleum ether-ethyl acetate to obtain 0.3 g. Identified as alisol A24-acetate.

[0047] Method b: According to the method b of Example 2, after the petroleum ether and chloroform (10:1) were eluted, then petroleum ether and chloroform (10:3) were eluted, and TLC was used to detect, collect the target fraction, and obtain crystallization 0.4 g, and 0.3 g of crystals were obtained after recrystallization from methanol. Identified as alisol A24-acetate.

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PUM

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Abstract

A medical composition is composed of the active components of alismatic rhizome, that is, the alisol A24-acetate and alisol B23-acetate in weight ratio of 1: (0.05-20). It can be used for treating hyperlipemia, fatty liver, atherosclerosis and coronary heart disease.

Description

technical field [0001] The invention relates to an alisma active component composition and its application in medicine. The composition contains alisol A24-acetate and alisol B23-acetate, and the total content of the two active ingredients is greater than 90%. The composition can be used to prepare oral preparations for treating hyperlipidemia and fatty liver, atherosclerosis and coronary heart disease caused by hyperlipidemia. Background technique [0002] With the improvement of material life, the incidence of hyperlipidemia is also increasing. The various cardiovascular and cerebrovascular diseases caused thereby have become the main culprit threatening the lives of middle-aged and elderly people. According to statistics, about 90 million people in my country suffer from hyperlipidemia. The etiology and pathogenesis of hyperlipidemia are complex, involving multiple factors and mechanisms. There are many types of hypolipidemic drugs developed for different pathogenesis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/20A61K9/48A61P1/16A61P9/10A61P3/06
Inventor 吴永平苏国强陆步实曹园边军
Owner 江苏省药物研究所有限公司
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