34results about How to "Inhibit scar hyperplasia" patented technology

The invention relates to a polysaccharide artificial blood vessel and a preparation method and application thereof. The polysaccharide artificial blood vessel is characterized in that the compact artificial blood vessel is prepared from water-insoluble polysaccharide fibers and colloidal solution which are prepared from polysaccharide; the polysaccharide is one or two of carboxymethylcellulose, hydroxy propyl cellulose, hydroxyethylcellulose, hyaluronic acid, alginate, heparin, chondroitin sulfuric acid, chitin, carboxymethyl chitin, hydroxypropyl chitin, hydroxyethyl chitin, carboxymethyl hydroxypropyl chitin, carboxymethyl hydroxyethyl chitin, hydroxypropyl hydroxyethyl chitin, sulfonated chitin, chitosan, carboxymethyl chitosan, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl hydroxyethyl chitosan, carboxymethyl hydroxypropyl chitosan, hydroxypropyl hydroxyethyl chitosan, sulfonated chitosan or succinyl chitosan. The polysaccharide artificial blood vessel has the high compactness, stretchability, bendability, mechanical strength and flexibility, can be implanted into bodies during the operation of trauma repair, and is used as artificial blood vessels to replace hurt vessels and improve blood-supply condition.

The invention relates to a Chinese medicinal composition for treating burns and scalds. The Chinese medicinal composition is composed of, by mass: 3-5 parts of propolis, 0.5-1 part of borneol, 5-15 parts of phellodendron, 10-20 parts of beeswax, 5-10 parts of Sanguisorba officinalis, 5-10 parts of radix rehmanniae, 5-10 parts of Rhizoma Coptidis, 5-10 parts of rhubarb, 5-10 parts of Scutellaria baicalensis, 1-3 parts of lithospermum, and 450-550 parts of sesame oil. The preparation method of the Chinese medicinal composition includes: grinding borneol, radix rehmanniae, Rhizoma Coptidis, and lithospermum into a fine powder respectively, and sieving the powder by a sieve of 80-120 meshes for standby use; putting sesame oil and beeswax into a pot, conducting heating and stirring simultaneously, and after melting of the beeswax, performing cooling to 70-80DEG C, adding borneol, further conducting cooling to 40-50DEG C, adding the residual components, stirring the mixture uniformly, thus obtaining a thick paste or paste. The Chinese medicinal composition provided by the invention solves the problems of long treatment cycle and slow effect in existing ointments for treating burns and scalds, has the effects of clearing away heat and toxic materials, removing necrotic tissues and promoting granulation, relieving pain, promoting blood circulation and removing blood stasis, and can effectively prevent infection and inhibit scar hyperplasia.

The invention discloses a composition containing earthworm protein as well as a preparation method and application of the composition. Effective components in the formula comprise the following components in parts by weight: 10-15 parts of earthworm freeze-dried powder or earthworm dry powder, 5-8 parts of a trollflower extract, 5-8 parts of a papaya extract, 5-8 parts of a centella asiatica extract, 3-5 parts of vitamin E and 5-8 parts of a humectant. Earthworm protein is adopted as a main active component, extracts of trollius chinensis bunge, pawpaw, centella asiatica and the like are matched according to a corresponding proportion to jointly serve as the active component, and the composition is used for repairing couperose skin hormone acne and has the effect of inhibiting scar hyperplasia of cystic or polymeric abscess. In the use process of the earthworm protein composition, pigmentation and scars on the skin of a patient suffering from hormonal acne can be prevented.

The invention belongs to the field of medical dressing, and particularly relates to wound surface restoration composite gel and a preparation method thereof. The wound surface restoration composite gel is prepared from the following ingredients in parts by weight: 1 to 5 parts of modified regeneration cellulose, 1 to 5 parts of chitosan, 10 to 20 parts of water, 1 to 5 parts of asiaticoside, 1 to 5 parts of anti-inflammatory agents, 3 to 8 parts of glycerol and 5 to 10 parts of gelatin. The wound surface restoration composite gel provided by the invention has the effects of obviously improving the hemostasis performance of chitosan materials, improving the mechanical strength of the chitosan gel and realizing the hypertrophic scar inhibition performance at the same time.

The invention relates to the field of a traditional Chinese medicine, and particularly relates to a drug for repairing a skin injury and a preparation method of the drug. The drug comprises a topical agent prepared from the following components in parts by weight: 20-25 parts of egg yolk oil, 15-25 parts of tetrastigma hemsleyanum, 15-20 parts of angelica oil, 10-15 parts of lavender essential oil and 25-40 parts of sesame oil. The drug for repairing the skin injury has good treatment effects on various degrees of skin injuries, and especially has a unique curative effect on deep second skin trauma. The curative effect is mainly reflected as follows: the skin injury can be cured by direct external application, does not need skin grafting, and is short in treatment cycle. The clinical test proves that the deep second skin trauma can be cured after 2-3 weeks when being treated by using the drug for repairing the skin injury. Compared with the traditional skin grafting, the treatment course is shortened by at least 10-30 days, and the drug can be used for stopping pain, resisting bacteria and diminishing inflammation, protecting the wound from being polluted, promoting wound healing, and carrying out reducing repairing on the skin, and is safe and free of a side effect.

The invention provides a composition for improving scar hyperplasia and hyperpigmentation in a skin repair process. The composition comprises the following raw materials: asiaticoside, heparin sodium, allantoin and indispensable auxiliary materials, and the composition further comprises the following raw materials in parts by weight: 0.03-0.5 part of clostridium histolyticum collagenase. By adopting the composition for improving the scar hyperplasia and hyperpigmentation in the skin repair process, scar tissue can be quickly softened, the drug can be quickly absorbed under the condition of realizing quick application operation of the drug, and acne pits and depression scars can also be improved.

The invention provides a preparation method and application of traditional Chinese medicinal hydrogel. The traditional Chinese medicinal hydrogel is prepared from cortex phellodendri extracting solution and hydrophilic matrix and has the effects of inhibiting hypertrophic scar, accelerating scar softening and preventing formation of scar tissue after operation; meanwhile, a preparation method is simple, and side effect is small, so that the traditional Chinese medicinal hydrogel can be widely applied in prevention of formation of scar tissue after operation.

The invention provides a composition for preventing scar proliferation. The composition comprises a scar removing component, a skin moisturizing component I and a skin moisturizing component II. The scar removing component comprises, by weight, 0.4-0.6 part of beef tallow tree butter, 0.4-0.6 part of avocado oil, 0.1-0.3 part of allantoin and 0.15-0.25 part of ginseng extract. The invention further provides a repairing cream, repairing gel and a repairing set. The repairing cream is made from the scar removing component and the skin moisturizing component I. The repairing gel is made from the skin moisturizing component II. The repairing set comprises the repairing cream and the repairing gel. The repairing set for preventing scar proliferation has the advantages that scar proliferation can be inhibited effectively, and wound healing can be promoted; the beef tallow tree butter, the avocado oil, the allantoin and the ginseng extract in the repairing cream have the effect of promoting wound healing and inhibiting scar proliferation; the rest components have the skin moisturizing effect; the repairing gel can promote cell renewing, keep cell activity and further improve scar suppression effect.

An artificial vessel of polysaccharide is composed of a layer of polysaccharide fiber and a film layer which is formed by coating polysaccharide solution on the layer of polysaccharide fiber. The polysaccharide is one or two compounds selected from the group consisting of carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, hyaluronic acid, alginate, heparin, chondroitin sulfate, chitin, hydroxymethyl chitin, hydroxypropyl chitin, hydroxyethyl chitin, carboxymethyl hydroxypropyl chitin, carboxymethyl hydroxyethyl chitin, hydroxypropyl hydroethyl chitin, sulfonated chitin, chitosan, carboxymethyl chitosan, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl hydroxyethyl chitosan, carboxymethyl hydroxypropyl chitosan, hydroxypropyl hydroethyl chitosan, sulfonated chitosan or succinyl chitosan. The artificial vessel of polysaccharide has good tightness, tensility, pliability, mechanical strength and flexibility.

The invention relates to the technical field of navel-protecting patches, and particularly relates to a manufacturing method of a silica gel navel-protecting patch. A backing layer is bonded to the lower surface of centrifugal paper I; the lower surface of the backing layer is coated with a silica gel layer; an absorption pad is bonded to the lower surface of the silica gel layer; a PE film is bonded to the lower surface of the absorption pad; an anti-sticking layer is bonded to the lower surface of the PE film; centrifugal paper II is bonded to the lower surface of the anti-sticking layer; and easy-to-tear openings are formed in the middle sections of the centrifugal paper II and the centrifugal paper I. The silica gel navel-protecting patch is simple in preparation process, can effectively avoid bacterium breeding, prevent wound infection and increase the wound healing speed, is waterproof, breathable, free of pain during stripping, convenient to carry and use and capable of inhibiting scar hyperplasia and avoiding the problem that sweat causes inflammation to the umbilical cord of an infant.

The invention provides a pharmaceutical composition for treating burns and scalds as well as a preparation method and application thereof. The pharmaceutical composition is prepared from an effectivecomponent a and an effective component b, <0}{0><}0{>wherein the component a has the effects of clearing away heat and toxic materials as well as diminishing inflammation and relieving pain and is prepared from the following raw materials: 10-40 parts of giant knotweed rhizome, 5-35 parts of dandelion herb, 5-35 parts of lithospermum herb and 1-20 parts of borneol; <0}{0><}0{>and the component b has the effects of promoting blood circulation and removing blood stasis as well as removing necrotic tissue and promoting tissue regeneration and is prepared from the following raw materials: 10-40 parts of radix et rhizoma rhei, 10-40 parts of garden burnet root, 1-20 parts of radix codonopsis, 1-20 parts of radix astragali and 50-200 parts of egg white. <0}{0><}0{>The pharmaceutical compositionhas the advantages that medicines are respectively applied according to different effects of the traditional Chinese medicines, so that synergetic effects of the Chinese traditional medicine components can be fully exerted; compared with single drug prescription administration, the pharmaceutical composition has more obvious and stable curative effects; <0}{0><}0{>the pharmaceutical composition ismainly used for treating diseases caused by red, swollen, hot and painful wounds in preliminary and intermediate stages of burns and scalds and obvious exudation, reducing wound infection, accelerating wound healing and effectively reducing formation of ulcers at burn and scald parts, and is low in cost and free of toxic or side effect; <0}{0><}0{>and the preparation method of the pharmaceuticalcomposition is simple and feasible, all parameters are controllable, and large-scale production is facilitated.

The present invention provides a composition for preventing scar hyperplasia, comprising a scar-removing component, an emollient component I and an emollient component II, and the scar-removing component includes the following ingredients in parts by weight: shea butter 0.4 ~0.6 parts, avocado oil 0.4~0.6 parts, allantoin 0.1~0.3 parts and ginseng root extract 0.15~0.25 parts. The present invention also provides the repairing cream made from the scar removing component and the moisturizing component I, the repairing gel made from the moisturizing component II, and the repairing suit composed of the repairing cream and the repairing gel. The repair kit for preventing scar hyperplasia provided by the present invention can effectively inhibit scar hyperplasia and promote wound healing; shea butter, avocado oil, allantoin and ginseng extract in the repair cream have the functions of promoting wound healing and inhibiting scar hyperplasia function; the rest of the ingredients have the effect of moisturizing and emollient; the repair gel can promote cell renewal, maintain cell activity, and further improve the effectiveness of scar suppression.

The invention provides an anti-scar biomaterial, a preparation method and use thereof, and relates to the technical field of biomedical materials. The material includes polysaccharide hydrogel and small molecule compound CSF1-R inhibitor. The anti-scar biomaterial of the invention can effectively inhibit the formation of hypertrophic scar and improve the curative effect of clinical tissue healing.

The invention discloses a Chinese medicinal composition for dispelling scars. The composition is prepared from oral administration medicaments and externally-applied medicaments, wherein the oral administration medicaments comprise but are not limited to the following raw material medicaments: angelica dahurica, peach seed, largehead atractylodes rhizome, job stears, Chinese angelica, Szechuan lovage rhizome, dipsacus asperoides, glabrous sarcandra herb, achyranthes root, earthworm, ground beetle, codonopsis pilosula, rhizoma drynariae, williams elder twig and white paeony root; and the externally-applied medicaments comprise but are not limited to the following raw material medicaments: dragon's blood, myrrh, safflower, Chinese angelica, suberect spatholobus stem, rose mallow root, pseudoginseng root, dipsacus asperoides, spreading hedyotis herb, frank incense, angelica dahurica, pearl, root of red-rooted salvia, williams elder twig, loofah sponge, rose and cortex moutan. The Chinesemedicinal composition is used for treating various burn scares and various scars formed after surgery and trauma and has the effects of activating blood and dissolving stasis, relaxing tendons and activating collaterals, detoxicating and diminishing swelling, softening hardness to dissipate stagnation, inhibiting scar hyperplasia, relieving scar itching, and softening the scars.

The invention discloses a clean fine-core sterile heterogeneous sigmoid membrane as well as a preparation method and clinical application thereof. A clean fine-core sterile heterogeneous sigmoid membrane biological novel material is successfully manufactured. A pig sigmoid membrane is taken as an animal model and subjected to experimental investigation of substrate application. The heterogeneous sigmoid membrane prepared by the preparation method disclosed by the invention can block body stress response of a patient with extensive burns, can lower super-high metabolism and can keep the remaining skin structure necessary for later-period skin regeneration. After the wound surface is cleaned and sterilized in a treatment process, the dressings can be not changed, skin can be not grafted, operation can be not carried out, the wound surface is protected from pollution and complication is avoided, so that cure rate for extensive burns is improved; moreover, scar hyperplasia is restrained, and disability rate of the patient is reduced.

Provided is a hydrogel scar removing patch and a preparation method. The hydrogel scar removing patch comprises a compound aloe hydraulic fixing layer, a silicone gel film and a polypropylene film stripping layer, the aloe hydraulic fixing layer is connected with the silicone gel film, and the upper portion of the silicone gel film is provided with the polypropylene film stripping layer. The hydrogel scar removing patch is used for treating bruises, scalds, scratches, cuts and the like.

The invention discloses an oligomeric chitosan medical wound care film and a preparation method thereof. The medical wound care film uses water-soluble oligomeric chitosan as a base material and can be made into solutions, sprays, etc., and has the functions of hemostasis, reducing The function of interstitial fluid exudation and prevention of tissue adhesion makes the product have good biocompatibility, hemostasis, antibacterial and moisturizing properties, and at the same time, it can also effectively prevent the liquefaction of wound fat. It can be used for wound treatment to prevent wound infection and promote rapid wound healing. , especially for the care of chronic hard-to-heal or burn wounds.

The invention relates to a medical composite nanofiber dressing and a preparation method thereof. The dressing is divided into inner and outer layers, wherein the inner layer contains polyvinyl alcohol, collagen and quaternized chitosan, and the outer layer contains polycaprolactone and dodecyl substituted quaternized silicone, polyvinyl alcohol, After mixing collagen and quaternized chitosan, the inner layer PCQC5 was prepared by electrospinning; polycaprolactone and dodecyl-substituted quaternized silicone QP12 were used as raw materials, and on the basis of the inner layer PCQC5, The outer layer was prepared by electrospinning. The dressing can be used in tissue repair or scar repair, and has wide applications in the field of antibacterial materials or medical devices.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating burns and inhibiting scar hyperplasiaand application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-20 parts of rhizoma coptidis, 5-20 parts of cortex phellodendri, 5-20 parts of radix scutellariae, 5-20 parts of raw rhubarb, 5-20 parts of polygonum cuspidatum, 5-20 parts of sanguisorba officinalis, 5-20 parts of tetrandrine, 5-20 parts of schisandra chinensis, 5-20 parts of angelica sinensis roots, 5-20 parts of dandelion herb, 1-3 parts of borneol and 800-1500 parts of vegetable oil. The traditional Chinese medicine composition has the effects ofremoving necrotic tissue, promoting granulation, promoting blood circulation to remove blood stasis, clearing away heat and toxic materials, inhibiting scar hyperplasia and promoting granulation to relieve pain. The traditional Chinese medicine composition has a remarkable curative effect on treatment of burns, scalds, diabetic feet, eczema and the like.

The invention provides a traditional Chinese medicine composition comprising extracts of Coptidis Rhizoma, Myrrha, Dandelion, Viola didin and peppermint oil. The present invention comprehensively utilizes the pharmacological effects of each medicinal material, and combines them to exert a synergistic effect, significantly improving the therapeutic effect of a single herb or several of them, and can be combined with a moisturizing and non-irritating matrix to make a compound Chinese medicine Ointment, which can specifically treat and alleviate skin diseases caused by tumor-targeting drugs.

The invention discloses an aerosol silicone dressing, and specifically relates to external use preparation compositions. The dressing consists of, by weight percentage, 0.5-60% of silicone, 0.1-12% offumed silica, 0.1-1% of an organosilicon antibacterial agent, and 0.01-3% of an anti-oxidant, with the balance being cyclopentasiloxane. The dressing is reasonable in formula and convenient in preparation, and can be used for the nursing of wounds after surgical or obstetric operations, especially the wound nursing of lateral episiotomy during spontaneous delivery; the dressing can make the wounds maintain moistening environments, so that the healing of the wounds can be effectively promoted, and scar hyperplasia can be inhibited; and the bacteriostatic ability of the dressing on staphylococcus aureus and escherichia coli can reach 95%.

The invention relates to a Chinese medicinal composition for treating burns and scalds. The Chinese medicinal composition is composed of, by mass: 3-5 parts of propolis, 0.5-1 part of borneol, 5-15 parts of phellodendron, 10-20 parts of beeswax, 5-10 parts of Sanguisorba officinalis, 5-10 parts of radix rehmanniae, 5-10 parts of Rhizoma Coptidis, 5-10 parts of rhubarb, 5-10 parts of Scutellaria baicalensis, 1-3 parts of lithospermum, and 450-550 parts of sesame oil. The preparation method of the Chinese medicinal composition includes: grinding borneol, radix rehmanniae, Rhizoma Coptidis, and lithospermum into a fine powder respectively, and sieving the powder by a sieve of 80-120 meshes for standby use; putting sesame oil and beeswax into a pot, conducting heating and stirring simultaneously, and after melting of the beeswax, performing cooling to 70-80DEG C, adding borneol, further conducting cooling to 40-50DEG C, adding the residual components, stirring the mixture uniformly, thus obtaining a thick paste or paste. The Chinese medicinal composition provided by the invention solves the problems of long treatment cycle and slow effect in existing ointments for treating burns and scalds, has the effects of clearing away heat and toxic materials, removing necrotic tissues and promoting granulation, relieving pain, promoting blood circulation and removing blood stasis, and can effectively prevent infection and inhibit scar hyperplasia.

The invention relates to a medical colloid dressing and application thereof, in particular to a medical colloid dressing with the effects of easing pain, promoting surface of burns and scalds healing and restraining bacteria and application thereof. The dressing mainly comprises water-soluble chitin and chlorhexidine.

The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises extracts of coptis chinensis, myrrh, dandelion and herba violae and peppermintoil. The pharmacological effects of the medicinal materials are comprehensively utilized and combined to achieve the synergistic effect, the treatment effect of one or more of the medicinal materialsis remarkably improved, the medicinal materials can be matched with a moisturizing and non-irritant matrix to be prepared into compound traditional Chinese medicine ointment, and skin diseases causedby tumor targeted medicine can be treated and relieved in a targeted mode.

The invention provides a traditional Chinese medicine composition for treating burn and scald and an ointment prepared by adopting the composition. The ointment has the effects of having obvious anti-inflammation and anti-infection properties, protecting the wound surface and reducing exudation, can obviously promote tissue regeneration and promote wound surface healing, and also can inhibit scarhyperplasia.