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Preparation method and application of clean fine-core sterile heterogeneous sigmoid membrane

A fine-core, heterogeneous technology, applied in medical science, bandages, prostheses, etc., to achieve the effect of inhibiting scar hyperplasia, reducing disability rate, and reducing hypermetabolism

Inactive Publication Date: 2015-05-13
刘邑卿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the rapid development of tissue engineering, great progress has been made in the basic research and clinical application of allogeneic skin substitutes, but there are still some problems to be solved before skin transplantation

Method used

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  • Preparation method and application of clean fine-core sterile heterogeneous sigmoid membrane
  • Preparation method and application of clean fine-core sterile heterogeneous sigmoid membrane
  • Preparation method and application of clean fine-core sterile heterogeneous sigmoid membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] A kind of preparation method of clean fine nuclei aseptic heterogeneous B film is characterized in that it is carried out according to the following steps:

[0061] a. Selection of raw materials: Select 40-60kg Ukrainian white pig back (60X90)㎝2 fresh membranes, use bromelain diluted to 0.1%-0.3% (w / w), soak in pure water at 30-40°C for 10-35 minutes, wash Afterwards, dry in the shade until the water content is 5%~8% (w / w); immerse again in water, shake dry and level off, dry on the glass operating table for 5~10 minutes, cut the width of 60cm, divide each film into equal parts, press " "Standard" specifications are divided into machine peeling film;

[0062] b. Clean the nail film on the glass surface. After manual fat removal, the nail film and the film B are driven off, and the collagen layer of the nail film is removed. The film B is ￠0.2㎝ input to the drum stripper to a thickness of 0.5㎜±0.02㎜, and put into the cleaning tank. Use 0.5% (w / w) physiological saline ...

Embodiment 2

[0072] The preparation method of the net fine nuclei sterile heterogeneous B membrane:

[0073] a. Selected raw materials: select 40kg Ukrainian white pig back (60X90)㎝2 fresh diaphragms, use bromelain diluted to 0.1% (w / w), soak in pure water at 30°C for 10 minutes, wash and dry in the shade until the water content is 5% (w / w); Immerse again in water, dry and level off, dry on the glass operating table for 5 minutes, cut to a width of 60cm, divide each film into equal parts, and separate them into machine peeling films according to the "standard" specification;

[0074] b. Clean the nail film on the glass surface. After manual fat removal, the nail film and the film B are driven off, and the collagen layer of the nail film is removed. The film B is ￠0.2㎝ input to the drum stripper to a thickness of 0.5㎜±0.02㎜, and put into the cleaning tank. Use 0.5% (w / w) normal saline to soak again under the liquid surface for 30 minutes, wash it twice with 39℃±2℃ pure water, dry it for ...

Embodiment 3

[0082] The preparation method of the net fine nuclei sterile heterogeneous B membrane:

[0083] a. Selection of raw materials: select 60kg Ukrainian white pig back (60X90)㎝㎝2 fresh membranes, use bromelain diluted to 0.3% (w / w), soak in 40°C pure water for 35 minutes, wash and dry in the shade until the water content is 8% (w / w); Immerse again in water, dry and level off, dry on the glass operating table for 10 minutes, cut to a width of 60cm, divide each film into equal parts, and divide them into machine peeling films according to the "standard" specification;

[0084]b. Clean the nail film on the glass surface. After manual fat removal, the nail film and the film B are driven off, and the collagen layer of the nail film is removed. The film B is ￠0.2㎝ input to the drum stripper to a thickness of 0.5㎜±0.02㎜, and put into the cleaning tank. Use 0.5% (w / w) physiological saline under the liquid surface, soak it again for 40 minutes, wash it twice with 39℃±2℃ pure water, dry ...

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Abstract

The invention discloses a clean fine-core sterile heterogeneous sigmoid membrane as well as a preparation method and clinical application thereof. A clean fine-core sterile heterogeneous sigmoid membrane biological novel material is successfully manufactured. A pig sigmoid membrane is taken as an animal model and subjected to experimental investigation of substrate application. The heterogeneous sigmoid membrane prepared by the preparation method disclosed by the invention can block body stress response of a patient with extensive burns, can lower super-high metabolism and can keep the remaining skin structure necessary for later-period skin regeneration. After the wound surface is cleaned and sterilized in a treatment process, the dressings can be not changed, skin can be not grafted, operation can be not carried out, the wound surface is protected from pollution and complication is avoided, so that cure rate for extensive burns is improved; moreover, scar hyperplasia is restrained, and disability rate of the patient is reduced.

Description

technical field [0001] The invention belongs to the technical field of disposable sterile medical devices, in particular to the field of biological dressings for surgical use in which the core and wall of the biological "B film" are driven away and presents a grid-like membrane, and in particular relates to "clean fine nuclei sterile heterogeneous B membrane matrix" and its preparation method and application. Background technique [0002] Disposable sterile medical biological dressings play an important role in saving lives in the treatment of patients with extensive burns and scalds. With the rapid development of tissue engineering, great progress has been made in the basic research and clinical application of allogeneic skin substitutes. However, there are still some problems to be solved before skin transplantation. In recent years, dermatologists at home and abroad have been seeking for good compatibility of wound repair covering materials, in order to eliminate reject...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/36A61L15/40
Inventor 刘邑卿
Owner 刘邑卿
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