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172 results about "Skin transplantation" patented technology

Skin grafting is a type of medical grafting involving the transplantation of skin. The transplanted tissue is called a skin graft.

Complaint implantable medical devices and methods of making same

InactiveUS6936066B2Give flexibilityFacilitating transmural endothelializationStentsHeart valvesSurgical GraftMetallic materials
Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and / or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
Owner:VACTRONIX SCI LLC

Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same

Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and / or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
Owner:VACTRONIX SCI LLC

Silver-containing, sol/gel derived bioglass compositions

Silver-containing, sol-gel derived bioactive glass compositions and methods of preparation and use thereof are disclosed. The compositions can be in the form of particles, fibers and / or coatings, among other possible forms, and can be used, for example, for treating wounds, improving the success of skin grafts, reducing the inflammatory response and providing anti-bacterial treatments to a patient in need thereof. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating the compositions into or onto the implanted materials. The compositions can also be used to prepare devices used for in vitro and ex vivo cell culture.
Owner:IMPERIAL INNOVATIONS LTD

Multi-directional and variably expanded sheet material surfaces

Expandable surfaces made from sheet materials with slits distributed on the surface of sheet material where the surfaces expand by application of force along or / and across the surface of sheet material. The unexpanded surfaces are flat sheets, or closed surfaces like cylinders, spheres, tubes, or custom-designed organic shapes marked with pre-formed or post-formed slit designs. The expanded surfaces can be single units or modules which can be attached to one another through various means. The sheet materials range from hard surfaces like metals, to softer materials like papers and plastics, or pliable materials like fabrics, rubbers, synthetic surfaces or bio-surfaces. The slits are arranged in patterns ranging from periodic, non-periodic to irregular designs. The slits can be straight, bent, curved or irregularly shaped with even or uneven spacing. Slitting can be achieved by digital cutting or punching devices like laser-cutting, water-jet cutting, digital punching, automated dies, etc. or pre-formed when casting the sheet material. Force can be applied manually with tools or through the use of machines and special set-ups. Applications range from architectural surfaces, walls, ceilings, panel systems, structures and sculpture. On a smaller scale, applications include containers, packaging material, fabrics and human wear. On micro- to nano-scale, applications range from expandable surfaces for gauzes, band-aids, stent designs, skin grafts, semi-permeable membranes and micro-filters for various industries including purification of fluids and chemical substances.
Owner:LALVANI HARESH

Skin grafting devices and methods

ActiveUS20050234485A1Ease reproducibilityShorten speedSurgeryWound drainsSkin graftingDonor skin
The present invention provides skin grafting and devices that comprise a systematic approach to the process of skin grafting, i.e., harvesting, post-excision processing and application of donor skin and pre and post-graft treatment of the recipient site.
Owner:KCI LICENSING INC

Microblister skin grafting

ActiveUS20130204273A1Reducing patient harm and discomfortAdd featureSurgical instruments for heatingSkin graftingBlisters
The present invention generally relates to devices for harvesting a skin graft(s). The present invention provides a blister raising device integrated with a member for cutting the blister.
Owner:3M INNOVATIVE PROPERTIES CO

Method for performing qualitative and quantitative analysis of wounds using spatially structured illumination

A method of noncontact imaging for performing qualitative and quantitative analysis of wounds includes the step of performing structured illumination of surface and subsurface tissue by both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform. Structured illumination of a skin flap is performed to monitor a burn wound, a diabetic ulcer, a decubitis ulcer, a peripheral vascular disease, a skin graft, and / or tissue response to photomodulation. Quantitative imaging of optical properties is performed of superficial (0-5 mm depth) tissues in vivo. The step of quantitative imaging of optical properties of superficial (0-5 mm depth) tissues in vivo comprises pixel-by-pixel demodulating and diffusion-model fitting or model-based analysis of spatial frequency data to extract the local absorption and reduced scattering optical coefficients.
Owner:RGT UNIV OF CALIFORNIA

Device for light irradiation onto tissue

A method and device for inducing or promoting growth and proliferation of skin cells or tissue or for controlling bacterial skin infection is described. The skin cells are irradiated with a low-intensity broad spectrum light at a wavelength of between about 340 to 3,000 nm. The increase in rate of cultivated cells is useful for example to obtain skin-like tissue needed for skin grafts or for promoting healing of skin wounds or lesions. Light-induced skin bacteria control is useful for example in the treatment of bacterial infections of the skin.
Owner:QRAY

Dermal substitute consisting of amnion and biodegradable polymer, the preparation method and the use thereof

The present invention relates to a dermal substitute comprising the biodegradable polymer such as collagen and the biomaterial such as amnion, the preparation method and the use thereof. Specifically, the present invention provides with an amnion-collagen sponge complex structure prepared by attaching, inserting or incorporating an amnion obtained from placenta to / in collagen. Inventive dermal substitute can be applied to surgery and wound requiring skin graft, for example, severe burns such as second-degree burn, without rejection by immune system. Further, inventive dermal substitute with amnion instead of silicone membrane has several advantages, such as better biocompatibility, anti-inflammatory activity and promoting activity of wound healing and commercial utilization as basement membrane. Also, inventive complex structure can be used as the basic matrix of bio-artificial skin for culturing cells and the biodegradable basic matrix for preparing artificial organs.
Owner:SK BIOLAND CO LTD

Protein-free defined media for the growth of normal human keratinocytes

Improvements are made to a novel media that replace the requirement for all protein growth factors by the addition to the medium of physiological concentrations of retinyl acetate. The media are serum-free, companion cell or feeder layer-free and organotypic, matrix free solutions for the cultivation of clonally competent basal keratinocytes. The media and methods are useful in the production of epidermal epithelial tissue that is suitable for skin grafting.
Owner:BIOPLAST MEDICAL

Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same

InactiveUS20070250156A1Give flexibilityFacilitating transmural endothelializationStentsBlood vesselsSurgical GraftMetallic materials
Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and / or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
Owner:VACTRONIX SCI LLC

Dermatome with ultrasonic cutting blade

InactiveUS20090138027A1Ultrasonic frequency is limitedSurgeryEye treatmentSkin graftingSkin transplantation
A dermatome assembly is operable to harvest a skin graft and includes an ultrasonic dermatome and a power supply. The ultrasonic dermatome includes a body and an ultrasonic blade assembly mounted in the body. The blade assembly includes a frequency generator and a cutting horn powered by the frequency generator. The cutting horn is spaced apart from the body so that the body is restricted from damping vibrational movement of the cutting horn. The dermatome assembly is operable to precisely control the thickness of the cut skin graft and also restrict the cutting horn from overheating.
Owner:DADSON MFG CORP

Devices and systems for separating and preparing skin

InactiveUS20050101972A1Eliminate unsuccessfulEliminate rudimentaryDiagnosticsSurgerySkin graftingPreparing skin
A skin graft preparing system includes a surgical device having a housing with a front end defining a forward direction and a rear end defining a rear direction for moving along skin in the forward direction. Cutting structure is moveably coupled to the housing for separating skin from the body where the cutting structure has a cutting portion. The cutting portion cyclically translates in the forward and rear direction without lateral movement. The skin graft preparing system also includes a skin graft preparing device having a base structure, one or more skin feeding structures, one or more skin preparing structures, and one or more skin collecting structures coupled to the base structure. The skin supporting structure from the surgical device provides the skin feeding structure of the skin graft preparing device.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Hand-held device for preparation of a skin graft by tangential excision of layers of tissue

Hand-held appliance for preparation of an excised skin graft, that is placed upon a plane surface, by tangential excision of tissue below the epidermis to produce a trimmed skin graft of desired remaining tissue layers and thickness with a blade that is held between two holding rods, that can be placed on a plane surface and that is held in a height-adjustable axis parallel to the surface. The end regions of the rods are shaped so that the distance between the axis and the contact surface of the edge of the end regions to the surface changes at least by sections, while the minimal distance and the maximal distance define the lowest and the highest cutting plane, respectively, so that the distance of the cutting plane is defined by the operating angle between the plane of the rods and the surface.
Owner:KASTEN KLAUS

Preparation method of tissue engineering skin containing hair follicles

InactiveCN101775366APerfect development conditionsOvercoming small quantitiesEpidermal cells/skin cellsPharmaceutical delivery mechanismEpitheliumCuticle
The invention relates to a preparation method of tissue engineering skin containing hair follicles. In the invention, tissue engineering hair follicles are evenly inoculated in a tissue engineering dermal layer formed by compounding a bracket material and cells, then the tissue engineering dermal layer is covered by epidermal cells, and the tissue engineering skin containing the hair follicles is formed after culture; the invention overcomes the defects of little number of the hair follicles in the skin, no uniformity and uncontrollable quantity of the hair follicles caused by mixed injection formerly, and the prepared tissue engineering skin contains an epidermis, dermis and hair follicle type tissue structure, wherein the number of the hair follicles approaches to the natural number, the hair follicles are evenly distributed in artificial pores and develop continuously after in-vitro culture and transplantation, a multi-layer concentric circle structure is formed, an inner layer is hair papilla cells wrapt by micro-capsule membranes, and an outer layer is epithelium class cells; and the skin cultured in vitro or transplanted in vivo finally forms functional skin containing a hair follicle accessory structure, and the regeneration of the hair follicles after skin transplantation can be realized.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY +1

Tissue-Engineered Constructs

Constructs including a tubular biodegradable polyglycolic acid scaffold may be coated with extracellular matrix proteins and are substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, an arterial graft, a venous graft, a duct graft, a skin graft, or a urinary graft or conduit.
Owner:HUMACYTE INC

Multimeric tie 2 agonists and uses thereof in stimulating angiogenesis

The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.
Owner:SUNNYBROOK HEALTH SCI CENT

Methods for ex vivo propagation of somatic hair follicle stem cells

ActiveUS20050272147A1Enhance guanine nucleotide biosynthesisSuppressing asymmetric cell kineticsBiocideEpidermal cells/skin cellsCell kineticsSomatic cell
The present invention is directed to methods for readily propagating somatic hair follicle stem cells or melanocyte stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods. For example, the resulting cultured somatic hair follicle stem cells can be used for a variety of applications including cell replacement therapies such as hair transplants, gene therapies, and tissue engineering applications, such as the generation of artificial skin and skin regeneration strategies including skin grafts.
Owner:MASSACHUSETTS INST OF TECH

Organization engineering skin containing peripheral hematopoietic stem cells and method of preparing the same

The present invention is a tissue engineering skin containing the peripheral blood stem cell and the preparation method. The present invention puts the peripheral blood stem cell and the skin fibroblast cell inside the biological frame. The active tissue engineering skin containing the peripheral blood stem cell is built by planting the epidermal cell on the surface. The tissue engineering skin is similar to the natural skin tissue in structure. Compared with the present skin replacing product, the present invention has properties of improving the blood supply in the wound and promoting the wound healing. The present invention can improve the elastic and toughness properties of the skin as well as the mechanical wear tolerance. The present invention can also reduce the scar proliferation and improve the healing quality. The present invention can improve the success rate of the artificial skin planting and can be effectively applied in repairing the skin defect, which is hard to heal.
Owner:陕西艾尔肤组织工程有限公司

Integrated implant system (IIS) biocompatible, biodegradable and bioactive, comprising a biocompatible sterile porous polymeric matrix and a gel, integrating in situ the tridimensional matrix structure

The present invention refers to an Integrated Implant System constituted as a gel-matrix-cells integrated system, that allows providing implants in a brief time period, for covering a great skin extension to be treated, with a successful acceptance in patients with burns, chronic damage or wound skin, needing of a skin grafting.
Owner:UNIV TECNICA FEDERICO SANTA MARIA +2

Double-layered artificial skin and its prepn process

The present invention provides one kind of double-layered artificial skin implant comprising one hypodermal layer containing polyglycollic acid and other biodegradable material, fibroblast and matrix protein; and one epidermal layer on the hypodermal layer. The artificial skin has continuous epidermal cell growing on the surface of the fibroblast-PGA composite, well cell differentiation and obvious lamination. The slice shows the artificial skin has the tissue structure characteristic similar to that of normal body skin. The preparation process and use of the artificial skin is also provided.
Owner:上海组织工程研究与开发中心
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