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Polysaccharide artificial blood vessel and preparation method and application thereof

A technology of artificial blood vessels and polysaccharides, applied in the field of polysaccharide artificial blood vessels and its preparation, can solve the problems of no side leakage prevention, prevention and treatment of stenosis, and can not be used as artificial blood vessel substitutes, so as to improve blood supply, promote growth, and have no immunogen sexual effect

Active Publication Date: 2011-01-05
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two invention patents, because they are woven into a mesh structure, can allow liquids such as blood to pass through the mesh, and have no side leakage prevention effect, so they can only be used for the prevention and treatment of stenosis in the lumen of blood vessels after surgery, and cannot be used as a substitute for artificial blood vessels

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take a stainless steel rod-shaped artificial blood vessel mold with a length of 30 cm and a diameter of 2 mm, uniformly wind the chitin polysaccharide fiber on the above-mentioned stainless steel rod-shaped artificial blood vessel mold to form a dense tubular structure, and then coat the chitin polysaccharide fiber tubular structure Cloth mass percentage concentration is the acetic acid hydrocolloid solution (the mass percentage concentration of acetic acid in the acetic acid hydrocolloid solution is 1%) of the chitosan of 2% (the same below), naturally dry into dense chitosan polysaccharide film, carefully The dense tubular structure made of chitin polysaccharide fiber and chitosan polysaccharide film was removed from the stainless steel rod-shaped artificial blood vessel mold, and then cut, packaged, 60 Co sterilized to prepare a polysaccharide artificial blood vessel with a cross-sectional inner diameter of 2 mm.

Embodiment 2

[0014] Take a stainless steel rod-shaped artificial blood vessel mold with a length of 30 cm and a diameter of 4 mm, and carboxymethylcellulose polysaccharide fibers are evenly wound on the above-mentioned stainless steel rod-shaped artificial blood vessel mold to form a dense tubular structure, and then wrapped in carboxymethyl cellulose The acetic acid hydrocolloid solution (the mass percentage concentration of acetic acid in the acetic acid hydrocolloid solution is 1%) of chitosan whose mass percentage concentration is 2% (the same below) is coated on the polysaccharide fiber tubular structure, and naturally dried into a compact shell Polysaccharide polysaccharide film, carefully remove the dense tubular structure made of carboxymethylcellulose polysaccharide fiber and chitosan polysaccharide film from the stainless steel rod-shaped artificial blood vessel mold, after cutting, packaging, 60 Co sterilized to prepare a polysaccharide artificial blood vessel with a cross-sectio...

Embodiment 3

[0016] Take a glass rod-shaped artificial blood vessel mold with a length of 20 cm and a diameter of 6 mm, and spin the thread made of chitosan polysaccharide fiber and chitin polysaccharide fiber at a mass ratio of 3:7, along the stainless steel rod-shaped artificial blood vessel mold. Weave to form a dense tubular structure, coat the above-mentioned 2% carboxymethyl chitin hydrocolloid solution on the tube, dry it naturally to form a dense carboxymethyl chitin polysaccharide film, carefully remove the above-mentioned from the glass rod-shaped artificial blood vessel mold A dense tubular structure made of chitin polysaccharide fiber, chitosan polysaccharide fiber and carboxymethyl chitin polysaccharide film, after cutting, packaging, 60 Co sterilized to prepare a polysaccharide artificial blood vessel with a cross-sectional inner diameter of 6 mm.

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Abstract

The invention relates to a polysaccharide artificial blood vessel and a preparation method and application thereof. The polysaccharide artificial blood vessel is characterized in that the compact artificial blood vessel is prepared from water-insoluble polysaccharide fibers and colloidal solution which are prepared from polysaccharide; the polysaccharide is one or two of carboxymethylcellulose, hydroxy propyl cellulose, hydroxyethylcellulose, hyaluronic acid, alginate, heparin, chondroitin sulfuric acid, chitin, carboxymethyl chitin, hydroxypropyl chitin, hydroxyethyl chitin, carboxymethyl hydroxypropyl chitin, carboxymethyl hydroxyethyl chitin, hydroxypropyl hydroxyethyl chitin, sulfonated chitin, chitosan, carboxymethyl chitosan, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl hydroxyethyl chitosan, carboxymethyl hydroxypropyl chitosan, hydroxypropyl hydroxyethyl chitosan, sulfonated chitosan or succinyl chitosan. The polysaccharide artificial blood vessel has the high compactness, stretchability, bendability, mechanical strength and flexibility, can be implanted into bodies during the operation of trauma repair, and is used as artificial blood vessels to replace hurt vessels and improve blood-supply condition.

Description

technical field [0001] The invention relates to a medical material, in particular to a polysaccharide artificial blood vessel and its preparation method and application. Background technique [0002] Artificial blood vessels play an important role in the treatment of vascular diseases and wound repair in young and middle-aged people. Artificial blood vessels were first successfully developed and used clinically in the 1950s. After a development experience from simple to complex, their performance has been continuously improved, and they are getting closer and closer to the performance requirements of ideal artificial blood vessels. Polyester, polytetrafluoroethylene, polyurethane and other materials have achieved satisfactory results in the manufacture of large-caliber (>6mm) artificial blood vessels, and the 5-year patency rate can reach more than 90%, so they are often used for large and medium-caliber arterial grafts. However, the above-mentioned materials have many p...

Claims

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Application Information

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IPC IPC(8): A61L27/20
CPCA61L27/34A61L27/20A61L27/507
Inventor 刘万顺韩宝芹孔晓颖潘学理
Owner 青岛博益特生物材料股份有限公司
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