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Wound surface restoration composite gel and preparation method thereof

A composite gel and wound repair technology, applied in medical science, bandages, etc., can solve the problems of poor anti-scar hyperplasia, low mechanical strength of gel, unsatisfactory hemostatic effect, etc. Infected, scar-free aesthetic results

Inactive Publication Date: 2017-08-22
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve technical problems such as the unsatisfactory hemostatic effect of the existing chitosan material, the low mechanical strength of the gel and the poor effect of resisting scar hyperplasia, and to provide a chitosan material that can significantly improve the hemostatic property and at the same time Composite dressing for improving mechanical strength of chitosan gel and imparting inhibition of scar hyperplasia

Method used

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  • Wound surface restoration composite gel and preparation method thereof
  • Wound surface restoration composite gel and preparation method thereof
  • Wound surface restoration composite gel and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0033] A wound repair composite gel is characterized in that it consists of the following components in parts by weight:

[0034] 1 part modified regenerated cellulose, 5 parts chitosan, 18 parts water, 1 part asiaticoside, 2 parts ciprofloxacin, 6 parts glycerin, 5 parts gelatin.

[0035] A preparation method of a wound repair composite gel, the specific process steps are as follows:

[0036] S1. Preparation of modified regenerated cellulose: immerse the regenerated cellulose fiber knitted fabric in an aqueous solution of sodium periodate with a mass percentage of 1%, adjust the pH value of the solution to 3; then place it in dark conditions at a temperature of 35 Continue to stir and react at ℃ for 2h; add 0.05mol / L ethylene glycol washing solution to remove all IO4-; then wash with high-purity water for 5 times, and freeze-dry to obtain substance 1; wash substance 1 and soak in silver ammonia In the solution, the molar ratio of the substance 1 to the solute in the silver-a...

Embodiment 2

[0041] A wound repair composite gel is characterized in that it consists of the following components in parts by weight:

[0042] 3 parts modified regenerated cellulose, 1 part chitosan, 10 parts water, 3 parts asiaticoside, 5 parts rifamycin, 3 parts glycerin, 10 parts gelatin.

[0043] A preparation method of a wound repair composite gel, the specific process steps are as follows:

[0044]S1. Preparation of modified regenerated cellulose: immerse the regenerated cellulose fiber knitted fabric in an aqueous solution of sodium periodate with a mass percentage of 4%, adjust the pH value of the solution to 2; then place it under dark conditions at a temperature of 30 Continue to stir and react at ℃ for 3h; add 0.08mol / L 1,3-propanediol washing solution to remove all IO4-; then wash with high-purity water for 3 times, and freeze-dry to obtain substance 1; wash substance 1, soak in In the silver-ammonia solution, the molar ratio of the substance 1 to the solute in the silver-ammo...

Embodiment 3

[0049] A wound repair composite gel is characterized in that it consists of the following components in parts by weight:

[0050] 4 parts modified regenerated cellulose, 3 parts chitosan, 15 parts water, 2 parts asiaticoside, 4 parts metronidazole, 4 parts glycerin, 6 parts gelatin.

[0051] A preparation method of a wound repair composite gel, the specific process steps are as follows:

[0052] S1. Preparation of modified regenerated cellulose: immerse the regenerated cellulose fiber knitted fabric in an aqueous solution of sodium periodate with a mass percentage of 3%, adjust the pH value of the solution to 2.5; then place it in dark conditions at a temperature of 40 Continue to stir and react at ℃ for 1 h; add 0.1mol / L polyethylene glycol washing solution to remove all IO4-; then wash with high-purity water for 4 times, and freeze-dry to obtain substance 1; wash substance 1 and immerse in silver In the ammonia solution, the molar ratio of the substance 1 to the solute in t...

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Abstract

The invention belongs to the field of medical dressing, and particularly relates to wound surface restoration composite gel and a preparation method thereof. The wound surface restoration composite gel is prepared from the following ingredients in parts by weight: 1 to 5 parts of modified regeneration cellulose, 1 to 5 parts of chitosan, 10 to 20 parts of water, 1 to 5 parts of asiaticoside, 1 to 5 parts of anti-inflammatory agents, 3 to 8 parts of glycerol and 5 to 10 parts of gelatin. The wound surface restoration composite gel provided by the invention has the effects of obviously improving the hemostasis performance of chitosan materials, improving the mechanical strength of the chitosan gel and realizing the hypertrophic scar inhibition performance at the same time.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a composite gel for wound repair and a preparation method thereof. Background technique [0002] In China, and even in the world, trauma is the main cause of wound formation and even death of patients. In addition, millions of surgical wounds are performed every year, making repairing appearance and maximizing the restoration of limb function become the challenges faced by orthopedic surgeons in many domestic medical institutions. problem. Although for patients without underlying diseases, most of the small wounds can be successfully closed, but for chronic wounds, complex wounds, local infections, the elderly and infirm or combined with underlying diseases, such as diabetes, vascular diseases, and tumors, etc. In patients, wound repair is difficult, and the relevant pathophysiological mechanism is still unclear. At the same time, the formation of some pathological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08B15/04
Inventor 卢亢陈锦涛熊亮
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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