A kind of medical composite nanofiber dressing and its preparation method and application

Abstract

The invention relates to a medical composite nanofiber dressing and a preparation method thereof. The dressing is divided into inner and outer layers, wherein the inner layer contains polyvinyl alcohol, collagen and quaternized chitosan, and the outer layer contains polycaprolactone and dodecyl substituted quaternized silicone, polyvinyl alcohol, After mixing collagen and quaternized chitosan, the inner layer PCQC5 was prepared by electrospinning; polycaprolactone and dodecyl-substituted quaternized silicone QP12 were used as raw materials, and on the basis of the inner layer PCQC5, The outer layer was prepared by electrospinning. The dressing can be used in tissue repair or scar repair, and has wide applications in the field of antibacterial materials or medical devices.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a medical composite nanofiber dressing with functions of hemostasis, antibacterial and anti-inflammatory, wound repairing and scar repairing functions, and a preparation method and application thereof. Background technique [0002] Trauma and postoperative hemostasis, infection prevention and scar treatment have always been the key and difficult problems to be solved urgently in clinical practice. Poor healing caused by trauma and postoperative wound repair time and complicated conditions, and even complications such as severe infection, sepsis, and ulcer cancer, may endanger the patient's life. [0003] Wound healing is the body's repair response to skin tissue defects. Normal skin wound healing consists of four distinct but overlapping phases, hemostatic, inflammatory, proliferative, and remodeling. When the four stages of wound healing are interrupted, chronic refr...

AI Technical Summary

Problems solved by technology

Medical materials can play a role in repairing chronic refractory wounds. At present, there are 2,400 kinds of wound dressings in the domestic and foreign markets, but all of them have problems such as single function and susceptibility to infection.

According to the "Practical Handbook on the Prevention and Control of Nosocomial Infections" issued by the World Health Organization (WHO), 60% of global clinical infections are related to the use of medical devices. In order to deal with infections caused by medical devices and implants, antibiotic systems are currently used clinically. treatment, but there are significant adverse reactions, allergic reactions and drug resistance

Clinically, functional materials with antibacterial properties have become the best choice. However, medical devices such as wound dressings currently used in clinical practice either have insufficient antibacterial activity or single functions, resulting in a series of problems such as frequent wound infection and poor wound and scar repair effects.

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