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A kind of oligomeric chitosan medical wound care film and preparation method thereof

The technology of oligomeric chitosan and polychitosan medicine is applied in the field of oligomeric chitosan medical wound care film and its preparation, which can solve the problem of poor film-forming effect of oligomeric chitosan, slow wound healing, and poor wound healing. Increase wound infection and other problems, achieve significant nursing effect, fast onset of hemostasis, and good healing effect

Active Publication Date: 2021-08-06
湖北中创医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this compound preparation process is complicated, and the oligomeric chitosan film-forming effect after grafting becomes worse, and hemostasis speed is slow, and moisturizing effect reduces, and it is difficult to provide reasonable moist environment to wound, makes wound healing speed slower, increases Symptoms of wound liquefaction due to the risk of wound infection

Method used

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  • A kind of oligomeric chitosan medical wound care film and preparation method thereof
  • A kind of oligomeric chitosan medical wound care film and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A medical wound care film of chitosan oligosaccharide, comprising the following raw materials in parts by weight: 20 parts of chitosan oligosaccharide, 8 parts of polyglutamic acid, 3 parts of perilla leaf extract, 2 parts of epidermal growth factor biomimetic peptide 3 parts of ultra-low viscosity potassium alginate, 5 parts of vitamin C, 5 parts of vitamin K, 2 parts of borneol, and 85 parts of water. Among them, the molecular weight of chitosan oligosaccharide is between 1850Da, and the degree of deacetylation is optimized to 95%; the viscosity of the ultra-low viscosity potassium alginate is 45cps; the epidermal growth factor biomimetic peptide is a small molecule containing 12 amino acids The polypeptide has a molecular weight of 1500Da and is packaged by nanotechnology, with an average particle size of 125nm.

[0028] The preparation method of oligomeric chitosan medical wound care film, comprises the steps:

[0029] (1) take each raw material by above-mentioned ...

Embodiment 2

[0035] A kind of oligomeric chitosan medical wound care film, compared with that of embodiment 1: raw material is identical, and preparation method is different, and concrete steps are:

[0036] (1) take each raw material by above-mentioned parts by weight;

[0037] (2) Add chitosan oligosaccharides, polyglutamic acid, and perilla leaf extract to part of the water, mix and stir at a high speed for 20 minutes at a temperature of 55°C, and stir at a speed of 500r / min, then add potassium alginate, and stir slowly 50min until uniform, ready for use, the average particle size of the solution is 450nm;

[0038] (3) Add vitamin C and vitamin K to the remaining water, stir at high speed for 4 minutes until uniform, then add epidermal growth factor biomimetic peptide, stir at high speed for 3 minutes, mix well, and set aside;

[0039] (4) Mix the solution prepared in step (2) with the solution prepared in step (3), and stir at a high speed for 15 minutes until uniform, adjust the pH v...

Embodiment 3

[0042] A medical wound care film of chitosan oligosaccharide, comprising the following raw materials in parts by weight: 15 parts of chitosan oligosaccharide, 15 parts of polyglutamic acid, 5 parts of perilla leaf extract, and 1 part of epidermal growth factor biomimetic peptide 5 parts, 5 parts of ultra-low viscosity potassium alginate, 2 parts of vitamin C, 8 parts of vitamin K, 5 parts of borneol, 60 parts of water; The molecular weight of the chitosan oligosaccharide is 2000Da, and the degree of deacetylation is optimized to 85%; The viscosity of the ultra-low viscosity potassium alginate is 60cps; the epidermal growth factor biomimetic peptide is a small molecule polypeptide containing 10 amino acids, the molecular weight is 2000Da, and it is wrapped by nanotechnology, with an average particle size of 150nm.

[0043] The preparation method of described chitosan oligosaccharide medical wound care film, comprises the steps:

[0044] (1) take each raw material by above-menti...

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Abstract

The invention discloses an oligomeric chitosan medical wound care film and a preparation method thereof. The medical wound care film uses water-soluble oligomeric chitosan as a base material and can be made into solutions, sprays, etc., and has the functions of hemostasis, reducing The function of interstitial fluid exudation and prevention of tissue adhesion makes the product have good biocompatibility, hemostasis, antibacterial and moisturizing properties, and at the same time, it can also effectively prevent the liquefaction of wound fat. It can be used for wound treatment to prevent wound infection and promote rapid wound healing. , especially for the care of chronic hard-to-heal or burn wounds.

Description

technical field [0001] The invention belongs to the technical field of medical wound care, and in particular relates to an oligomeric chitosan medical wound care film and a preparation method thereof. Background technique [0002] Wound healing usually refers to a series of physiological processes through the repair and regeneration of defective tissue caused by injury, which is manifested by the synergistic effect of complex combinations such as tissue regeneration, granulation growth, and scar formation. Wounds can be divided into acute wounds and chronic wounds according to time, and can be divided into superficial wounds and full-thickness wounds according to the depth of the skin involved in the injury. The reasons for delayed wound healing are mainly related to the patient's age, self-sensitivity, nutritional status, diabetes and other factors, while external factors may be related to the degree of wound damage, infection, and fat liquefaction. Therefore, to avoid del...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61K9/70A61K47/36A61P17/02A61P31/04A61P31/02A61P7/04A61K31/785A61K31/722A61K36/535A61K31/734A61K31/375A61K31/05A61K31/045
CPCA61K9/7015A61K31/045A61K31/05A61K31/375A61K31/722A61K31/734A61K31/785A61K36/535A61K38/1808A61K47/36A61K2300/00
Inventor 张雨成宋炜冯世忠杜小青戴琦
Owner 湖北中创医疗用品有限公司
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