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A kind of epidermal wound repair ointment and preparation method thereof

A technology of wound repair and ointment, applied in the field of biomedicine, which can solve the problems of high product cost, inconspicuous repair effect, and complicated extraction process, and achieve the effects of easy industrial production, inhibition of scar hyperplasia, and cheap and easy-to-obtain raw materials

Active Publication Date: 2019-02-22
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, there are many raw materials for the preparation of traditional Chinese medicine ointment, and the extraction of some active ingredients of traditional Chinese medicine is complicated.
For example, there are more than 30 kinds of traditional Chinese medicine in a certain scald ointment. Its extraction process is very complicated, the cost of raw materials is high, and the product cost is expensive.
In addition, most of the commercially available ointments are only suitable for superficial (I degree) burns, the repair effect is not obvious, and there are obvious scars after repair

Method used

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  • A kind of epidermal wound repair ointment and preparation method thereof
  • A kind of epidermal wound repair ointment and preparation method thereof
  • A kind of epidermal wound repair ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Dissolve 44 g of chitosan (molecular weight 3 kDa, degree of deacetylation 80%) with 18 g of purified water to make a chitosan solution; add 8 g of active peptide and 9 g of glycerin to it, and mix well to obtain a chitosan mixture solution; disperse 0.1 g of agar gel with 14.9 g of pure water, and dissolve it by heating to make an agar gel solution; pour the agar gel solution into the above-mentioned chitosan mixed solution, mix well, add 6 g of calamari that has passed through a 140 mesh sieve Stone powder, mix again, and let it stand for 8 hours to obtain the epidermis wound repair ointment.

Embodiment 2

[0036] Dissolve 47 g chitosan (molecular weight 3 kDa, degree of deacetylation 85%) with 15 g purified water to make a chitosan solution; add 9.4 g active peptide and 8.5 g glycerin to it, and mix well to obtain a chitosan mixture solution; disperse 0.1 g of agar gel with 10 g of pure water, and dissolve it by heating to make an agar gel solution; pour the agar gel solution into the above-mentioned chitosan mixed solution, mix well, and add 10 g of it through a 140-mesh furnace Ganshi powder, mix again, and let stand for 10 hours to obtain the epidermal wound repair ointment.

Embodiment 3

[0038] Dissolve 40 g of chitosan (molecular weight 5 kDa, degree of deacetylation 90%) with 20 g of purified water to make a chitosan solution; add 10 g of active peptide and 6 g of glycerin to it, and mix well to obtain a chitosan mixture solution; disperse 0.2 g of agar gel with 18.8 g of pure water, and dissolve it by heating to make an agar gel solution; pour the agar gel solution into the above-mentioned chitosan mixed solution, mix well, add 4 g of calamari that has passed through a 140 mesh sieve Stone powder, mix again, and let it stand for 12 hours to obtain the ointment for repairing epidermal wounds.

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Abstract

The invention discloses a skin wound repair ointment and a preparation method thereof. The skin wound repair ointment is prepared from chitosan, a bioactive peptide, calamine, glycerin, agar and water. The preparation method comprises the following steps: (1) dissolving chitosan into water to prepare a chitosan solution, adding the bioactive peptide and glycerin so as to obtain a chitosan mixed solution; (2) dispersing the agar into water, and heating until the agar is dissolved so as to prepare an agar solution; (3) mixing the agar solution and the chitosan mixed solution, adding powdered calamine, uniformly mixing, and standing. According to the method disclosed by the invention, the natural antibiotic chitosan serves as a main matrix and is compounded with the bioactive peptide with effects of promoting wound healing and inhibiting scar hypertrophy, the binding state is regulated by adopting the calamine, the prepared skin wound repair ointment achieves the effects of resisting bacteria and diminishing inflammation, removing slough and promoting growth of tissue regeneration, clearing away heat and toxic materials, converging healing, inhibiting scar hypertrophy and the like and is particularly applicable to treatment of scalds and burns of deep II degree or higher, and no obvious scar residue exist.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically relates to an ointment for repairing epidermal wounds and a preparation method thereof. Background technique [0002] Serious injuries such as burns and scalds often occur in life. According to statistics, 5-10 million people in my country suffer from such injuries every year. Severe burns not only bring huge economic pressure to patients and their families, but also bring indelible psychological damage to themselves. [0003] External preparations clinically used to treat burns and scalds include traditional Chinese medicine preparations and western medicine preparations. Western medicine preparations are usually made of some antibacterial substances, such as antibiotic ointment including tetracycline ointment, oxytetracycline ointment, chloramphenicol ointment, erythromycin ointment, ciprofloxacin ointment, norfloxacin ointment, etc., containing silver Ointments incl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/01A61K9/06A61K47/36A61P17/02A61K33/30A61K31/722
CPCA61K9/0014A61K9/06A61K31/722A61K33/30A61K38/01A61K47/36A61K2300/00
Inventor 胡章李思东洪鹏志杨萍孔松芝程瑜黄娜廖铭能
Owner GUANGDONG OCEAN UNIVERSITY
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