Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Polysaccharide artificial blood vessel and preparation method and application thereof

An artificial blood vessel and polysaccharide technology, applied in the field of polysaccharide artificial blood vessel and its preparation, can solve the problems of prevention and treatment of stenosis, can not be used as a substitute for artificial blood vessel, and has no anti-side leakage effect, so as to promote growth, inhibit scar hyperplasia, and improve blood supply status Effect

Active Publication Date: 2013-10-30
青岛博益特生物材料股份有限公司
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two invention patents, because they are woven into a mesh structure, can allow liquids such as blood to pass through the mesh, and have no side leakage prevention effect, so they can only be used for the prevention and treatment of stenosis in the lumen of blood vessels after surgery, and cannot be used as a substitute for artificial blood vessels

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take a stainless steel rod-shaped artificial blood vessel mold with a length of 30 cm and a diameter of 2 mm, uniformly wind the chitin polysaccharide fiber on the above-mentioned stainless steel rod-shaped artificial blood vessel mold to form a dense tubular structure, and then coat the chitin polysaccharide fiber tubular structure Cloth mass percentage concentration is the acetic acid hydrocolloid solution (the mass percentage concentration of acetic acid in the acetic acid hydrocolloid solution is 1%) of the chitosan of 2% (the same below), naturally dry into dense chitosan polysaccharide film, carefully The dense tubular structure made of chitin polysaccharide fiber and chitosan polysaccharide film was removed from the stainless steel rod-shaped artificial blood vessel mold, and then cut, packaged, 60 Co sterilized to prepare a polysaccharide artificial blood vessel with a cross-sectional inner diameter of 2 mm.

Embodiment 2

[0014] Take a stainless steel rod-shaped artificial blood vessel mold with a length of 30 cm and a diameter of 4 mm, and carboxymethylcellulose polysaccharide fibers are evenly wound on the above-mentioned stainless steel rod-shaped artificial blood vessel mold to form a dense tubular structure, and then wrapped in carboxymethyl cellulose The acetic acid hydrocolloid solution (the mass percentage concentration of acetic acid in the acetic acid hydrocolloid solution is 1%) of chitosan whose mass percentage concentration is 2% (the same below) is coated on the polysaccharide fiber tubular structure, and naturally dried into a compact shell Polysaccharide polysaccharide film, carefully remove the dense tubular structure made of carboxymethylcellulose polysaccharide fiber and chitosan polysaccharide film from the stainless steel rod-shaped artificial blood vessel mold, after cutting, packaging, 60 Co sterilized to prepare a polysaccharide artificial blood vessel with a cross-sectio...

Embodiment 3

[0016] Take a glass rod-shaped artificial blood vessel mold with a length of 20 cm and a diameter of 6 mm, and spin the thread made of chitosan polysaccharide fiber and chitin polysaccharide fiber at a mass ratio of 3:7, along the stainless steel rod-shaped artificial blood vessel mold. Weave to form a dense tubular structure, coat the above-mentioned 2% carboxymethyl chitin hydrocolloid solution on the tube, dry it naturally to form a dense carboxymethyl chitin polysaccharide film, carefully remove the above-mentioned from the glass rod-shaped artificial blood vessel mold A dense tubular structure made of chitin polysaccharide fiber, chitosan polysaccharide fiber and carboxymethyl chitin polysaccharide film, after cutting, packaging, 60 Co sterilized to prepare a polysaccharide artificial blood vessel with a cross-sectional inner diameter of 6 mm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
lengthaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

An artificial vessel of polysaccharide is composed of a layer of polysaccharide fiber and a film layer which is formed by coating polysaccharide solution on the layer of polysaccharide fiber. The polysaccharide is one or two compounds selected from the group consisting of carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, hyaluronic acid, alginate, heparin, chondroitin sulfate, chitin, hydroxymethyl chitin, hydroxypropyl chitin, hydroxyethyl chitin, carboxymethyl hydroxypropyl chitin, carboxymethyl hydroxyethyl chitin, hydroxypropyl hydroethyl chitin, sulfonated chitin, chitosan, carboxymethyl chitosan, hydroxypropyl chitosan, hydroxyethyl chitosan, carboxymethyl hydroxyethyl chitosan, carboxymethyl hydroxypropyl chitosan, hydroxypropyl hydroethyl chitosan, sulfonated chitosan or succinyl chitosan. The artificial vessel of polysaccharide has good tightness, tensility, pliability, mechanical strength and flexibility.

Description

technical field [0001] The invention relates to a medical material, in particular to a polysaccharide artificial blood vessel and its preparation method and application. Background technique [0002] Artificial blood vessels play an important role in the treatment of vascular diseases and wound repair in young and middle-aged people. Artificial blood vessels were first successfully developed and used clinically in the 1950s. After a development experience from simple to complex, their performance has been continuously improved, and they are getting closer and closer to the performance requirements of ideal artificial blood vessels. Polyester, polytetrafluoroethylene, polyurethane and other materials have achieved satisfactory results in the manufacture of large-caliber (>6mm) artificial blood vessels, and the 5-year patency rate can reach more than 90%, so they are often used for large and medium-caliber arterial grafts. However, the above-mentioned materials have many p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20
CPCA61L27/34A61L27/20A61L27/507
Inventor 刘万顺韩宝芹孔晓颖潘学理
Owner 青岛博益特生物材料股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com