Anti-scar biomaterial, preparation method and use thereof
A biomaterial and scar technology, which is applied in the field of biomedical materials, can solve the problems of hypertrophic scar treatment without particularly effective and mature methods, and the treatment effect is not ideal, so as to achieve the goal of inhibiting scar hyperplasia, good healing effect, and adjustable strength Effect
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Embodiment 1
[0040] 1.1 Preparation of anti-scar biomaterials:
[0041] 1) Weigh 500mg of GW2580 solid powder with an electronic balance and place it in a 15ml sterile centrifuge tube.
[0042] 2) Pipette 5ml of VitroGel 3D-RGD hydrogel and transfer to the above centrifuge tube.
[0043] 3) Fully shake on a vortex shaker for 10 minutes, and mix until it becomes gelatinous.
[0044] 4) Store in a refrigerator at 4°C for later use. The solid diagram of the anti-scar biomaterial is shown in figure 1 .
[0045] 1.2 Anti-scar biomaterial for scarring in rat tail
[0046] Subjects: 15 SPF male Balb / c mice aged 7-11 weeks, weighing 19-22 g, were selected and divided into 3 groups on average.
[0047] Hypertrophic scar model construction and application of anti-scar biomaterials for treatment:
[0048] 1) At a dose of 50 mg / kg, mice were intraperitoneally injected with 1% sodium pentobarbital. After the onset of anesthesia, the skin was disinfected with iodophor, and a sterile towel was sprea...
Embodiment 2
[0064] 2.1 Preparation of anti-scar biomaterials:
[0065] Same as 1.1 in Example 1
[0066] 2.2 Anti-scar biomaterials used for scarring in rabbit ears
[0067] Subjects: 15 male New Zealand white rabbits aged 10-14 weeks, weighing 2-3kg, were divided into 3 groups on average.
[0068] Hypertrophic scar model construction and application of anti-scar biomaterials for treatment:
[0069] 1) Weigh an appropriate amount of urethane crystals, put them into a measuring bottle, and add an appropriate amount of double distilled water to it to prepare a 20% urethane solution for later use.
[0070] 2) Take male New Zealand white rabbits and inject 20% urethane solution into the ear vein at a dose of 5ml / kg.
[0071] 3) After the anesthesia was stabilized, iodophor was used to carefully disinfect the inner and outer surfaces of both ears 3 times. Lay sterile sheets.
[0072] 4) Drill holes on the inner surface of bilateral rabbit ears with a circular trephine. After drilling thro...
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