47results about How to "Improve formulation quality" patented technology

The invention provides a high-purity antibiotic medicinal compound, and in particular relates to a method for refining beta-lactam penicillin antibiotic medicinal compounds. In the method, an acid-base pH method and a macroporous absorption resin method are effectively combined; and beta-lactam penicillin antibiotic medicinal compounds are refined and purified under specific process parameters to prepare over 99.9 percent high-purity beta-lactam penicillin antibiotic medicinal compounds with yield over 90 percent, so that unexpected purification effect is achieved. The high-purity beta-lactam penicillin antibiotic medicinal compounds are prepared by the method, so that the stability of corresponding preparations thereof and clinical application effect can be improved. The method is simple, has low cost, is easily for operation, and is applicable to large-scale industrial production.

The invention discloses a sand production line. The sand production line comprises a sand feeding hopper, a composite feeding machine, a primary crusher, a secondary crusher, a cleaning device, a grading device and a classifying stock bin, wherein a discharging port of the sand feeding hopper is connected to the feeding end of the composite feeding machine, the discharging end of the composite feeding machine is connected to a feeding hopper I of the primary crusher, a collecting hopper I of the primary crusher is connected to a feeding hopper II of the secondary crusher through a conveying belt, a collecting hopper II of the secondary crusher is connected to the cleaning device through a conveying belt, the cleaning device is connected to the grading device through a conveying belt, and the grading device is connected to the classifying stock bin through a conveying belt. According to the sand production line, by means of the sand feeding hopper, the composite feeding machine, the primary crusher, the secondary crusher, the cleaning device, the grading device and the classifying stock bin, automatic and continuous sand production can be realized, the production efficiency is high, the labor intensity can be reduced, and automatic monitoring and unattended operation can be realized.

The invention relates to pesticide preparation equipment, in particular to mechanical pesticide preparation equipment for planting fruits and vegetables. The invention aims at providing the mechanicalpesticide preparation equipment for planting the fruits and the vegetables, which has the advantages that pesticide is uniformly mixed, labor force is saved and prepared pesticide has high quality. For solving the technical problem, the invention provides the mechanical pesticide preparation equipment for planting the fruits and the vegetables; the mechanical pesticide preparation equipment comprises a base plate, a guide rail, a guide block, a test tube, a valve, a support, a preparation tank, a driving wheel, a sector rotary table, a connecting rod, a discharging ball and the like, whereinthe guide rail is arranged at the top middle of the base plate; the guide block is arranged inside the guide rail in a sliding manner; the test tube is arranged at the top of the guide block; a firstdischarging pipe is arranged at the lower part of the left wall of the test tube; the valve is arranged at the left part of the first discharging pipe. According to the mechanical pesticide preparation equipment disclosed by the invention, the effects that the pesticide is uniformly mixed, the labor force is saved and the prepared pesticide has higher quality are achieved; multi-time preparation of a pesticide mixing liquid is realized by mechanical operation and the preparation quality of the pesticide mixing liquid is improved on the premise of saving time and labor.

The invention discloses a making method of tri-gold dispersing pill and a preparation method, which is characterized by the following: decompressing to condense the boiled raw material; spraying to dry condensate; adding fitful micro-crystal cellulose, micro-powder silica gel and sodium carboxymethylstarch through wet-method to grain or adding fitful quantity of micro-crystal cellulose to grain further; grinding the needed particle; pressing; obtaining the product. The preparation method not only can prepare tri-gold dispersing pill with characters including easy taken, fast absorption and high bioavailability, and all indexes are up to the specification in chinese pharmacopoeia; and in condition of the same crude drug amount, the amount of the effective constituent asiaticoside is much higher than the amount of tri-gold capsule.

The invention relates to a preparation method for a traditional Chinese medicine oral preparation with traditional Chinese medicines as main materials. One, two or three raw medicines of the medicine composites are shattered and sifted out; the other non-shattering raw medicines are grouped or not grouped, decocted and extracted with water, concentrated and refined; the shattering and sifting rawmedicine powder is used as basic charge by added in one or two components of proper starch, dextrine and micro silica gel, and water extract is injected for a one-step granulation for troche, capsule, pill, granular formulation and other formulations. The invention has a feasible technology, decreases the impurity in the extract and the loss of the active ingredient in the extraction process, thegranulation is more convenient, the grain is more uniform, the subsequent working procedures of tabletting and enpsulation are easier; the prepared traditional Chinese medicine compound preparation for curing the gout disease has the advantages of high preparation quality, low clinical dose and other advantages; each index of the product is fully qualified, and the quality of the product is improved greatly.

The invention relates to a preparation device, in particular to an electrolyte preparation device. A technical problem to be solved in the invention is to provide an electrolyte preparation device which is easy to control and good in preparation quality. In order to solve the technical problem above, the electrolyte preparation device comprises a mounting frame, a cylinder body, a discharge pipe,a valve, a piston, a nut, guide sleeves, guide rods, a feed hopper, a first bearing, a first rotating shaft, a first gear, and a mounting plate, wherein the cylinder body is arranged in the middle ofthe upper wall of the mounting frame; the discharge pipe is arranged at the lower part of the right wall of the cylinder body; the valve is arranged on the discharge pipe; the piston is arranged at the lower part in the cylinder body and is in fit with the cylinder body; the nut is arranged in the middle of the piston; the guide sleeves are arranged symmetrically on the lower wall of the cylinderbody in the left-right direction; and the guide rods are arranged in the guide sleeves in a sleeving manner. The device has effects of proportion control easiness and good preparation quality. In thedevice, the piston can move up and down through continuous clockwise-anticlockwise rotation of blades, and the piston and the blades are matched with each other, so that the preparation quality of electrolyte is relatively good.

The invention belongs to the technical field of medicine, and relates to a biological adhesive compound lung aspiration nanometer composite microparticle and preparation thereof. The prepared nanometer composite microparticle is formed by simultaneously embedding nanometer crystals of one or two kinds of water-soluble anti-asthma and chronic pulmonary obstruction medicine and another kind of insoluble anti-asthma and chronic pulmonary obstruction medicine into a biological adhesive framework material. The composite microparticle uses a spray drying technology, and can realize the effects that1, the dissolution difficulty of the insoluble medicine is improved; the synchronous release of several kinds of medicine with different dissolution properties can be realized; the cooperated effectsare better achieved; 2, the uniform mixing of several kinds of medicine with different dose differences can be ensured; the technical process of the preparation is greatly simplified; the medicine quality is improved; the cost is reduced; the energy consumption is reduced; 3, through the application of the biological adhesive material, the lung mucous cilia clearing effect resistance can be effectively realized; the lung retention time is prolonged; the medicine concentration in the focus position is improved; the medicine absorption is delayed; the goals of improving the curative effect and reducing the whole body toxic and side effects can be achieved.

The invention discloses a gravel production gradation adjustment device. The gravel production gradation adjustment device comprises a grading screen, and the grading screen comprises multiple layers of screens; the screen I of which the mesh diameter is 4.75 mm, the screen II of which the mesh diameter is 3 mm, the screen III of which the mesh diameter is 1.25 mm, the screen IV of which the mesh diameter is 0.25 mm, the screen V of which the mesh diameter is 0.16 mm and the screen VI of which the mesh diameter is 0.075 mm are sequentially arranged from top to bottom; the discharge ends of the screens are connected to material collection hoppers; each material collection hopper is connected to one bin through a pipeline; weighing devices are arranged at discharge openings of the bins; a belt conveyer is arranged in front of the weighing devices; and the discharge end of the belt conveyer is connected to a stirring machine. According to the gravel production gradation adjustment device, classification of six-grade stone of which the particle sizes are 0 mm to 0.075 mm, 0.075 mm to 0.16 mm, 0.16 mm to 0.25 mm, 0.25 mm to 1.25 mm, 1.25 mm to 3 mm, and 3 mm to 4.75 mm can be achieved, weighing is achieved through the weighing devices, finally, stone of the required gradation is matched according to different utilization requirements and is put into the stirring machine to be stirred and mixed, stone powder of the required gradation can be better prepared, preparation quality of stone powder is improved, selectivity is high, and gradation adjustment can be effectively controlled.

The invention provides a spraying device for spraying vehicle leathers, belongs to the technical field of spraying machines, and solves the problem of bad waste in the prior art. In the spraying device for spraying the vehicle leathers, a production line for machining the vehicle leathers comprises a base and a frame fixed on the base; the spraying device comprises a working base, a rotating motor, a rotating frame, multiple nozzles and multiple induction probes; the working base is fixed on the base; the rotating motor is fixed above the working base through a bracket, and an output shaft isvertical upwards; the rotating frame comprises a rotating shaft; a mounting base is fixed at the top of the rotating shaft; multiple slide rails are horizontally and annularly arranged on the mountingbase; slide bars are slidingly arranged on the slide rails; mounting blocks are fixed on the slide bars; the nozzles and the induction probes are fixed on the mounting blocks; multiple first push rodmotors are arranged on the mounting bases; and output shafts of the first push rod motors are coaxially connected with the slide bars through connecting bars. The spraying device for spraying the vehicle leathers has the advantage of decelerating wastes of spraying liquid.

The invention discloses a method for increasing a softening point of extract powder of traditional Chinese medicine extracts, and is characterized in that a proper amount of composite auxiliary materials are added into a traditional Chinese medicine extraction concentrate with a low softening point; the composite auxiliary materials comprise plasdone S-630, light magnesium oxide, and maltodextrin; the mixture is stirred for uniform dispersion; and extract powder with a high softening point is obtained after drying the concentrate. The advantages of the invention are that: 1) the method of the invention is simple; only a few composite auxiliary materials are added during the extract concentration process; the composite auxiliary materials have good dissolvability; and the production time is not prolonged basically; 2) various auxiliary materials contained in the composite auxiliary materials are all auxiliary materials commonly-used in preparations, and have no toxicity or adverse reactions after administration; 3) the adding amount of the auxiliary materials is low; patient compliance is improved; the price is low; and the production cost is reduced to the maximal extent; 4) the composite auxiliary materials not only increase the softening point of the material, but also have the characteristics of moisture resistance, smell masking and fluidity improvement of traditional Chinese medicine preparation raw materials, and can provide convenience for preparation manufacturing and improve preparation quality.

The invention belongs to the technical field of machine manufacturing, relates to a machine tool cutting fluid rapid preparation device for machine manufacturing, and aims to adjust the hardness of water. The device comprises a preparation box; a feeding box with low water hardness and a feeding box with high water hardness are arranged on the outer wall of the top of the preparation box; naturalcoral sand and a cation exchange resin layer are arranged on the inner walls of the feeding box with low water hardness and the feeding box with high water hardness respectively, a conveying belt anda second conveying belt are arranged on the two sides of the inner wall of the preparation box respectively, and scrapers distributed at equal intervals are arranged on the outer walls of one sides ofthe conveying belt and the second conveying belt respectively. By arranging the feeding box with low water hardness, the natural coral sand, the feeding box with low water hardness, the cation exchange resin layer, the conveying belt, the second conveying belt, the scrapers and a cleaning brush, different feeding boxes are selected for feeding according to the hardness value of water, the hardness of the water can be improved or reduced to a certain extent, and the preparation quality of a cutting fluid is improved.

The invention relates to a concrete mixing device, in particular to an energy-saving concrete mixing device. An energy-saving concrete mixing device capable of saving energy, automatically controlling preparation time and automatically controlling output is provided. An energy-saving concrete mixing device includes: a bottom plate; a cylinder installed on the bottom plate; a stirring assembly installed on the bottom plate and stirring by rotating; a sliding discharge assembly installed on the cylinder. The invention can not only prepare the concrete but also release the prepared concrete through the geared motor, which not only saves energy, but also makes the equipment more convenient to use. At the same time, the prepared concrete can be released regularly through the control components. It not only facilitates the use of the equipment, but also improves the quality of concrete preparation. Through the auxiliary discharge component, the concrete can be discharged quickly and conveniently, and the equipment is more convenient to use.

A Chinese medicine in the form of injection of any orally taken form for treating the infection of respiratory tract and digestive system, improving immunity, and preventing tumor is proportionally prepared from Asiatic moonseed rhizome or its extract and the 14-dehydroxy-11,12-didehydro andrographolide-3,19-semiester succinate or its pharmacologically acceptable salt.

The invention discloses a pigment preparation device for drawing oil painting. Through cooperative use of a heat preservation layer, a heating layer and a temperature controller, the interior of a machine body is kept at a stable temperature all the time, and the pigment preparation quality can be improved; through the arrangement of a weighing device, after the pigment is prepared, the prepared pigment can be directly weighed and equally divided, subsequent production is facilitated, and the production efficiency is improved; and through the arrangement of a cleaning device, after the pigmentis prepared, the interior of a preparation cylinder can be conveniently cleaned, the pigment can be conveniently used when the pigment is prepared again, and the labor intensity of workers is reduced. According to the pigment preparation device for drawing the oil paintings provided by the invention, a fine ingredient adding assembly and a cleaning assembly are integrally installed together and extend into the machine body, space is saved, meanwhile, holes on a machine cover can be reduced, and through the arrangement of a visual window, a colorimetric bar and a control panel, colors can be accurately compared, the comparison effect is improved, and the accuracy of the prepared pigment is guaranteed.

The invention discloses a benvitimod impurity as well as a preparation method and application thereof. The prepared benvitimod impurity is high in purity and can be used as an impurity reference substance in benvitimodbulk drug or preparation detection, accurate positioning of the impurity 6-methyl-5-[(E)-2-styryl]-2-isopropyl-1,3-benzenediol in production quality control of benvitimod is improved, control over the impurity is enhanced, and the quality of the benvitimod preparation is improved, so that the safety and the effectiveness of the benvitimod preparation in clinical use are ensured.

The invention relates to a conveying device and method of liquid crystal display glass materials for improving the whole uniformity of auxiliary materials, and the device comprises electronic scale, where the electronic scale is connected through wearable pipeline with a collection bunker, the lower part of the collection bunker is provided with material discharge paddle and vibrating device, the collection bunker is connected with a material mixing machine through the material discharge paddle; firstly after weighed by the electronic scale, the raw materials are discharged in sequence and then enter through the wearable pipeline into the collection bunker, and as discharging, a part of the quartz powder is discharged from the raw materials, other raw materials are then discharged then, and finally the remaining quartz powder is discharged, and after all the raw materials are discharged into the collection bunker, they are discharged into the material mixing machine, so as to obtain the required auxiliary materials for the liquid crystal glass. And it can improve the whole uniformity of the auxiliary materials, especially applied to liquid crystal glass batching production lines with higher requirements for the quality of the auxiliary materials.

The invention provides a production line for processing automobile leather, and belongs to the technical field of leather processing. The problem that the processing efficiency is low in the prior artis solved. The production line for processing the automobile leather comprises a base and a machine frame fixed to the base, one end of the machine frame is provided with a feeding frame, the other end of the machine frame is provided with a discharge frame, a first conveying roller and a plurality of second conveying rollers are rotationally arranged on the machine frame, one end of the first conveying roller is connected with a driving motor capable of enabling the first conveying roller to rotate, a first chain wheel is coaxially fixed to the other end of the first conveying roller, the second conveying rollers are arranged parallel to the first conveying roller, a second chain wheel is fixed to the ends of the second conveying rollers, a first chain is arranged between the first chainwheel and the second chain wheels in a sleeving mode, a spraying device capable of achieving spraying for the automobile leather is arranged above the second conveying rollers, a drying device capable of drying the automobile leather is arranged at the end close to the discharge frame, and the machine frame is further provided with a preparation mechanism capable of preparing coating liquid. Theproduction line has the advantage of improving processing efficiency.

The invention discloses a triamcinolone tablet, a triamcinolone polymorphs and a preparation method. The triamcinolone tablet comprises a triamcinolone polymorphs 1 serving as active ingredients and one or more pharmaceutic adjuvants applicable to tablets, X-ray powder diffraction of the triamcinolone polymorphs 1 has characteristic peaks at diffraction angles 2theta=9.0 degrees, 15.6 degrees, 18.5 degrees and 21.7 degrees.

The invention relates to the glass fiber impregnating compound preparation automatic control technical field, and specifically relates to a glass fiber impregnating compound preparation automatic control system comprising a controller; the controller is externally connected with an analog input output module; the input port of the analog input output module is externally connected with a viscositysensor, an oil temperature sensor, a water temperature sensor, a raw material flowmeter and a hot water flowmeter; the viscosity sensor is externally connected with a frequency meter; the input end of a controller switch value I / O module is externally connected with a water level upper limit detector, a water level lower limit detector, and a frequency transition annunciator; the output end of the controller switch value I / O module is externally connected with a raw material valve, an agitator motor, a steam valve, a hot water valve, a normal temperature water valve and a tap water valve. Thesystem can precisely control the key technique parameters, thus effectively preventing artificial operations from affecting the production stability, improving the impregnating compound preparation quality, reducing the worker laboring intensity, reducing operator quantity, reducing cost, and increasing gains.

The invention relates to injection alprostadil freeze-dried emulsion. A freeze-drying protective additive of the emulsion consists of special amino acid and arbohydrate, wherein the amino acid and the arbohydrate are added to alprostadil lipid emulsion, so as to prepare the injection alprostadil freeze-dried emulsion which is quite high in stability through a certain freeze-drying process. The freeze-dried emulsion not only meets requirements of storing a preparation at normal temperature, but also effectively improves safety of the preparation and reduces adverse reaction incidence through replacing other freeze-drying protective additives by the amino acid.

The invention discloses a making method of tri-gold dispersing pill and a preparation method, which is characterized by the following: decompressing to condense the boiled raw material; spraying to dry condensate; adding fitful micro-crystal cellulose, micro-powder silica gel and sodium carboxymethylstarch through wet-method to grain or adding fitful quantity of micro-crystal cellulose to grain further; grinding the needed particle; pressing; obtaining the product. The preparation method not only can prepare tri-gold dispersing pill with characters including easy taken, fast absorption and high bioavailability, and all indexes are up to the specification in chinese pharmacopoeia; and in condition of the same crude drug amount, the amount of the effective constituent asiaticoside is much higher than the amount of tri-gold capsule.

The invention provides a slow and controlled release coating tablet dissolution degree stability improving method. When the coating agent is of organic solvent, the optimal time for adding coating dry powder can be acquired by detecting the change of the emission concentration of organic solvent vapor of the exhausted gas of a coating machine with the time. The method is convenient to operate, the accuracy of the result is high, the preparation quality of slow and controlled release coating tablets can be improved effectively, and the stable solution degree is provided.

The present invention provides a preparation method for anti -tumor drugs Miriplatin: prepare a mixed solution for diet metamimam and orthopedly, heating up, add rice platinum coarse products, heat preservation until it is completely dissolved, and the rice platinum coarse solution;After the solution is clarified, add activated carbon to continue the preservation, filter, and collect the filter liquid; cool the filter liquid, add toluene, heat preservation and stir; after the reaction is over, cool down again, precipitate crystals, and keep the crystal.Wash, dry, get Microlatin boutique.The preparation method provided by the present invention is simple, the income is high, the purity of rice platinum reaches more than 99.9 %, the maximum single miscellaneous control is below 0.1 %, and the total miscellaneous control is within 0.2 %.

The invention relates to the technical field of non-woven fabric processing, and discloses a non-woven fabric liquid preparation system capable of realizing automatic liquid preparation, wherein the non-woven fabric liquid preparation system comprises a base, a box body, a stirring middle rod, a reciprocating stirring assembly, a rotary anti-precipitation assembly, a fixed block and a feeding pipe; the top end of the base is fixedly connected with the box body, and the top end of the box body is fixedly connected with the fixed block; the left side of the inner wall of the box body is fixedly connected with the feeding pipe, the reciprocating stirring assembly is movably connected with the top end of the inner wall of the box body, the stirring middle rod is movably connected with the bottom end of the reciprocating stirring assembly, and the rotating anti-precipitation assembly is movably connected with the bottom end of the inner wall of the box body. According to the non-woven fabric liquid preparation system and method capable of realizing automatic liquid preparation, a movable cylinder drives a sleeve column to rotate through a spiral groove and a second rolling ball, so that a stirring bottom rod rotates, a mixed solution at the bottom of the inner wall of the box body is precipitated and scattered, the mixed solution is uniformly stirred, the preparation quality of the mixed solution is improved, and the final product quality of the non-woven fabric is improved.

The invention relates to an isofraxidin crystalline compound and glabrous sarcandra herb dispersible tablets and dropping pills containing the isofraxidin crystalline compound. X-ray powder diffraction spectrogram characteristic peaks of the isofraxidin crystalline compound are measured by Cu-Ka rays and displayed at positions with 2theta being 6.8 degrees, 11.4 degrees, 12.0 degrees, 12.6 degrees, 14.8 degrees, 15.8 degrees, 18.0 degrees, 19.4 degrees, 20.1 degrees, 21.7 degrees, 23.4 degrees, 25.6 degrees, 28.0 degrees, 29.0 degrees and 30.6 degrees. Stability, bioavailability and quality of the glabrous sarcandra herb dispersible tablets and dropping pills are evidently improved, so that medication safety is guaranteed for patients. In addition, the glabrous sarcandra herb dispersible tablets and dropping pills have the advantages of stability in quality, accuracy in dosage, small difference in purity, easiness in implementation of mass mechanical production, high yield and low cost.

The invention relates to a preparation method for a traditional Chinese medicine oral preparation with traditional Chinese medicines as main materials. One, two or three raw medicines of the medicine composites are shattered and sifted out; the other non-shattering raw medicines are grouped or not grouped, decocted and extracted with water, concentrated and refined; the shattering and sifting raw medicine powder is used as basic charge by added in one or two components of proper starch, dextrine and micro silica gel, and water extract is injected for a one-step granulation for troche, capsule, pill, granular formulation and other formulations. The invention has a feasible technology, decreases the impurity in the extract and the loss of the active ingredient in the extraction process, the granulation is more convenient, the grain is more uniform, the subsequent working procedures of tabletting and enpsulation are easier; the prepared traditional Chinese medicine compound preparation for curing the gout disease has the advantages of high preparation quality, low clinical dose and other advantages; each index of the product is fully qualified, and the quality of the product is improved greatly.

The present invention provides a compound 1-containing cardiovascular disease treating oral preparation. According to the present invention, by controlling the bulk density during a dry granulation process within a specific range, the granulation level of the dry granulation is improved, the preparation process is optimized, the preparation quality is improved, and the obtained product is suitable for the clinical application compared to the product prepared in the prior art.