Method for increasing softening point of extract powder of traditional Chinese medicine extract

Abstract

The invention discloses a method for increasing a softening point of extract powder of traditional Chinese medicine extracts, and is characterized in that a proper amount of composite auxiliary materials are added into a traditional Chinese medicine extraction concentrate with a low softening point; the composite auxiliary materials comprise plasdone S-630, light magnesium oxide, and maltodextrin; the mixture is stirred for uniform dispersion; and extract powder with a high softening point is obtained after drying the concentrate. The advantages of the invention are that: 1) the method of the invention is simple; only a few composite auxiliary materials are added during the extract concentration process; the composite auxiliary materials have good dissolvability; and the production time is not prolonged basically; 2) various auxiliary materials contained in the composite auxiliary materials are all auxiliary materials commonly-used in preparations, and have no toxicity or adverse reactions after administration; 3) the adding amount of the auxiliary materials is low; patient compliance is improved; the price is low; and the production cost is reduced to the maximal extent; 4) the composite auxiliary materials not only increase the softening point of the material, but also have the characteristics of moisture resistance, smell masking and fluidity improvement of traditional Chinese medicine preparation raw materials, and can provide convenience for preparation manufacturing and improve preparation quality.

Description

(1) Technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a method for increasing the softening point of extract powder of traditional Chinese medicine. (2) Background technology [0002] For amorphous materials, the solid-liquid transition is a gradual process from softening to melting, and there is no definite transition temperature, so the concept of "softening point" is derived. The softening point is usually used to characterize the solid-liquid transition critical temperature of amorphous materials, and is usually measured by a Vicat softening point tester. [0003] The raw materials of traditional Chinese medicine compound or single preparations are generally amorphous mixtures composed of dozens or even hundreds of substances, so the softening point is an inherent property of the raw materials of traditional Chinese medicine preparations. At present, although there are few reports on the softening po...

AI Technical Summary

Problems solved by technology

After the traditional Chinese medicine extract is dried into extract powder, the single dose is relatively large. If a large amount of excipients are added, it is easy to take a large dose of preparations such as more than 5 tablets or more than 12g of granules in a single dose. Significantly reduced patient compliance

In addition, adding a large amount of auxiliary materials will greatly increase the production cost of the enterprise and reduce the economic benefits.

Images