Method for increasing softening point of extract powder of traditional Chinese medicine extract

A softening point, traditional Chinese medicine technology, applied in pharmaceutical formulas, plant raw materials, medical preparations with inactive ingredients, etc., can solve the problems of increasing production costs, reducing economic benefits, reducing patient compliance, etc. Production time, effect of increasing softening point

Active Publication Date: 2012-08-22
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the traditional Chinese medicine extract is dried into extract powder, the single dose is relatively large. If a large amount of excipients are added, it is easy to take a large dose of preparations such as more than 5 tablets or more than 12g of granules in a single dose. Significantly reduced patient compliance
In addition, adding a large amount of auxiliary materials will greatly increase the production cost of the enterprise and reduce the economic benefits.

Method used

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  • Method for increasing softening point of extract powder of traditional Chinese medicine extract
  • Method for increasing softening point of extract powder of traditional Chinese medicine extract
  • Method for increasing softening point of extract powder of traditional Chinese medicine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Cornus officinalis Extract Powder

[0030] Get 250 ml of the water extract of Cornus officinalis (ρ=1.035, solid content 0.35%), and spray dry it to obtain Cornus officinalis extract powder I.

[0031] Get Cornus officinalis water extract (ρ=1.035, solid content 10%) 250ml, add 10% plasdone S-630, 15% light magnesia and 1% maltodextrin according to the percentage that accounts for the solid content of extraction concentrated solution and dissolve and mix with Cornus officinalis The extract was mixed evenly, and after spray drying, the cornus officinalis extract powder II was obtained.

[0032] Determination of softening point

[0033] Utilize the Vicat softening point tester to measure the softening point of Cornus officinalis extract powder, and the experimental results are shown in the following table:

[0034] Table 1 Determination results of softening point of Cornus officinalis extract powder

[0035]

[0036] The experimental results showed th...

Embodiment 2

[0044] Preparation of Eucommia Extract Powder

[0045] Take 250 ml of eucommia water extract (ρ=0.994, solid content 0.35%) and spray dry to obtain eucommia extract powder I.

[0046] Take 250ml of eucommia water extract (ρ=0.994, solid content 0.35%), add 7% plasdone S-630, 7% light magnesium oxide and 3% maltodextrin to dissolve, mix with eucommia extract and spray dry to obtain Eucommia Extract Powder II.

[0047] Determination of softening point

[0048] Utilize the melting point apparatus to measure the softening point of Eucommia traditional Chinese medicine extract powder, the experimental results are shown in the following table:

[0049] Table 2 Determination results of softening point of eucommia extract powder

[0050]

[0051] The experimental results show that after adding auxiliary materials, the softening point of Eucommia extract powder II is significantly improved.

[0052] Investigation on the Interference of Compound Excipients on Effective Components...

Embodiment 3

[0059] Preparation of Hawthorn Extract Powder

[0060] Get 250ml of hawthorn water extract (ρ=1.01, solid content 6.8%), carry out spray drying, obtain hawthorn extract powder I.

[0061] Take 250ml of hawthorn water extract (ρ=1.01, solid content 6.8%), add 3% plasdone S-630, 8% light magnesium oxide and 5% maltodextrin to dissolve, mix with hawthorn extract and spray dry to obtain Hawthorn Extract Powder II.

[0062] Determination of softening point

[0063] The softening point of hawthorn traditional Chinese medicine extract powder was determined by melting point apparatus, and the experimental results are shown in the following table:

[0064] Table 3 Determination results of softening point of eucommia extract powder

[0065]

[0066] The experimental results showed that the softening point of hawthorn extract powder II was significantly improved after adding auxiliary materials.

[0067] Investigation on the Interference of Compound Excipients on Active Components...

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Abstract

The invention discloses a method for increasing a softening point of extract powder of traditional Chinese medicine extracts, and is characterized in that a proper amount of composite auxiliary materials are added into a traditional Chinese medicine extraction concentrate with a low softening point; the composite auxiliary materials comprise plasdone S-630, light magnesium oxide, and maltodextrin; the mixture is stirred for uniform dispersion; and extract powder with a high softening point is obtained after drying the concentrate. The advantages of the invention are that: 1) the method of the invention is simple; only a few composite auxiliary materials are added during the extract concentration process; the composite auxiliary materials have good dissolvability; and the production time is not prolonged basically; 2) various auxiliary materials contained in the composite auxiliary materials are all auxiliary materials commonly-used in preparations, and have no toxicity or adverse reactions after administration; 3) the adding amount of the auxiliary materials is low; patient compliance is improved; the price is low; and the production cost is reduced to the maximal extent; 4) the composite auxiliary materials not only increase the softening point of the material, but also have the characteristics of moisture resistance, smell masking and fluidity improvement of traditional Chinese medicine preparation raw materials, and can provide convenience for preparation manufacturing and improve preparation quality.

Description

(1) Technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a method for increasing the softening point of extract powder of traditional Chinese medicine. (2) Background technology [0002] For amorphous materials, the solid-liquid transition is a gradual process from softening to melting, and there is no definite transition temperature, so the concept of "softening point" is derived. The softening point is usually used to characterize the solid-liquid transition critical temperature of amorphous materials, and is usually measured by a Vicat softening point tester. [0003] The raw materials of traditional Chinese medicine compound or single preparations are generally amorphous mixtures composed of dozens or even hundreds of substances, so the softening point is an inherent property of the raw materials of traditional Chinese medicine preparations. At present, although there are few reports on the softening po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K47/36
Inventor 杜若飞冯怡阮克锋李洁
Owner SHANGHAI UNIV OF T C M
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