31results about How to "Good research and development prospects" patented technology

The invention discloses houttuynoids and a preparation method and application thereof. The houttuynoids have a structural formula as represented by formula (I) which is described in the invention; in the formula (I), R1 is represented by formula (I), formula (II), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX) or formula (X) as described in the invention, and R2 is hydrogen or is represented by formula (XI), formula (XII), formula (XIII) or formula (XIV) as described in the invention. 12 houttuynoids are separated from Saururaceae Houttuynia cordata Thunb. and are all furan-flavones with novel structures. An in-vitro anti-herpes simplex virus activity screening system is used for evaluating activity of the houttuynoids, and it is found that the houttuynoids can effectively inhibit a herpes simplex virus; thus, the houttuynoids have effects on preventing and treating herpes simplex virus infection, can be applied to preparation of drugs used for resisting the herpes simplex virus and have good research and development prospects.

The invention discloses an alkaloid compound, and the structure identification of the isolated compound is carried out by means of physicochemical properties and modern spectroscopy methods. The invention also uses the activity screening system of LPS-induced RAW 264.7 cell inflammation model to evaluate its activity, and it is found that the compound has a certain protective effect on the mouse macrophage cell line RAW 264.7, can significantly inhibit PGE2, and shows a strong Anti-inflammatory effect.

The invention which belongs to the technical field of medicines relates to new compounds with the anti-HSV activity and having a general formula represented by formula (I). R in the formula (I) is defined in the specification. The invention also relates to a use and preparation methods of the compounds, and an application of the compounds in the clinical preparation of clinically acceptable medicines for treating HSV-infected diseases through combining the compounds with pharmaceutically acceptable carriers. The structure of the general formula (I) is shown in the specification.

The invention discloses a mixed-source terpenoid compound with the function of protecting the liver. The mixed-source terpenoid compound has the structures shown in formula (I) and formula (II): experiments prove that the formula (I) and formula (II) of the present invention The mixed-source terpenoids shown in (II) have significant protective effects on the liver cell damage caused by paracetamol, suggesting that the mixed-source terpenoids shown in formula (I) and formula (II) can be used as liver-protecting drugs with good research and development prospects.

The invention discloses a preparation method and application of grosvenoria grosvenori flower in water pipes of flower and fruit burning and smoking category, comprising the following steps: (a) cracking the dried fruit of grosvenoria grosvenori into pieces → loading samples → adding tap water → standing, soaking for 24-48 hours (b) Use water bath heating extraction method (extract once) → leachate → filter with 400 mesh filter cloth, seal and stand still to obtain filtrate A, (c) add 50% ethanol solution → acid precipitation extraction, fully stir → filtrate; (d) Filtrate A → Concentrate under reduced pressure at 55-60°C for 3 hours → obtain concentrated solution A (relative density ρ=1.2918), (e) add concentrated solution A to raw material 20% propylene glycol 60g → shake well → obtain concentrated solution A, the density is measured as : ρ=1.1286, (f) The obtained concentrated solution A is the natural plant Luo Han Guo extract for the preparation of Arabian hookah. The present invention can effectively improve the aroma quality, aroma quantity, fineness and / or sweetness of the hookah, reduce the irritation and / or burnt gas of the Arabian hookah, and improve the sensory quality of the hookah.

The invention belongs to the technical field of medicines and discloses new diarylheptanoid compounds extracted and separated from Guangxi curcuma zedoary and application thereof in the field of medicines. The chemical structure of the diarylheptanoid compounds is determined by spectrum technology such as a high resolution mass spectrum, one-dimensional and two-dimensional nuclear magnetic resonance spectrum and the like, and a chemical method. The diarylheptanoid compounds can be combined with a pharmaceutically acceptable carrier to prepare clinically acceptable medicines for anti-inflammatory treatment. Experiments for inhibiting lipopolysaccharide-induced rat macrophage from synthesizing nitric oxide (NO) in vitro prove that: the diarylheptanoid compounds have high activity of inhibiting the nitric oxide from being generated, and can be used as anti-inflammatory medicines for preventing and / or treating human and animals.

The invention discloses an alkaloid dimer compound with PD-1 / PD-L1 binding inhibitory effect, and the alkaloid dimer compound has the structure shown in the following formula: The polymer compounds have a significant inhibitory effect on PD-1 / PD-L1 binding, suggesting that these alkaloid dimer compounds can be used as PD-1 / PD-L1 binding inhibitors in tumors, inflammatory diseases, autologous Treatment of immune diseases, bacterial infections, viral infections, fungal infections and other diseases.

The invention provides an aircraft takeoff-landing magnetorheological fluid boosting / damping runway of an aircraft carrier. The runway is formed by assembling magnetorheological fluid boosting / damping units. Each magnetorheological fluid boosting / damping unit is composed of a radar probe, a damping magnetorheological fluid pack, a protection mat, a magnetorheological fluid control device, a closed side guard, a magnetorheological fluid delivery pipe, an accumulator, a control ECU, an electric / power generating hydraulic pump, a reflux accumulation magnetorheological fluid pack, a reflux accumulation magnetorheological fluid pack electromagnetic extrusion device, a pressure sensor and the like, the bottom surface of the damping magnetorheological fluid pack communicates with the magnetorheological fluid delivery pipe, and the magnetorheological fluid delivery pipe passes through the magnetorheological fluid control device, and communicates with the reflux accumulation magnetorheological fluid pack after being connected with the electric / power generating hydraulic pump in series. According to the invention, landing damping and takeoff boosting can be realized for an aircraft, the instantaneous impact momentum of bullets, that is shrapnels is absorbed, and the momentum passes a circulation liquid flow generating system after being absorbed. Compared with the current aircraft carrier arresting cable, the runway is simple in structure, does not cause casualties, and has good research and development prospects.

The invention discloses a microbial conversion product of curcumenol, its use and preparation method. The structure of the transformation product is 1 α -Hydroxycurcumenol. The conversion product 1 α -Hydroxycurcumenol can be used as an anti-inflammatory drug for the prophylaxis and / or treatment of humans and animals. Mucor echinocystis Mucor ? spinosus? AS? 3.2450 biotransforms the substrate curcumenol, and uses ethyl acetate to extract the converted product in the fermentation broth, and uses silica gel column chromatography to separate and purify the converted product. The obtained conversion product has a purity of over 98%.

The invention discloses a sesquiterpene compound with lipase inhibitory effect. This type of sesquiterpene compound has the structures shown in formula (I) and formula (II): experiments have proved that formula (I) and formula (II) of the present invention The lipase activity of the sesquiterpenoids shown in formula (II) has significant inhibitory effect, suggesting that the sesquiterpenoids shown in formula (I) and formula (II) can be used as blood lipid-lowering, anti-obesity drugs or health products, with Good prospects for research and development.

The invention discloses physapubescin, and an extraction method and application thereof. The physapubescin has a structure as shown in a formula (I) which is described in the specification. Experimental results show that the physapubescin as shown in the formula (I) and physapubescin aglycon as shown in a formula (II) can inhibit the activity of lipopolysaccharide in induction of mouse macrophagesto release nitric oxide, so it is proved that the physapubescin as shown in the formula (I) and the physapubescin aglycon as shown in the formula (II) can be used as anti-inflammatory drugs; and theresults of activity evaluation via an in-vitro antitumor activity screening system show that the physapubescin as shown in the formula (I) and the physapubescin aglycon as shown in the formula (II) can effectively inhibit the growth of hormone-independent prostate cancer cells, different types of renal cancer cells and human malignant melanoma cells, so it is proved tha the physapubescin as shownin the formula (I) and the physapubescin aglycon as shown in the formula (II) can be used as medicines for treating tumors and have good research and development prospects.

The invention which belongs to the technical field of medicines relates to new compounds with the anti-HSV activity and having a general formula represented by formula (I). R in the formula (I) is defined in the specification. The invention also relates to a use and preparation methods of the compounds, and an application of the compounds in the clinical preparation of clinically acceptable medicines for treating HSV-infected diseases through combining the compounds with pharmaceutically acceptable carriers. The structure of the general formula (I) is shown in the specification.