30 results about "Hepatoprotective Drugs" patented technology

The invention relates to application of a steroid saponin compound in medicinal materials of trillium or paris polyphylla to preparation of a liver protection medicine. The prepared steroid saponin compound in the medicinal materials of trillium or paris polyphylla is one or more of pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI), pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside and pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside (namely polyphyllin VII), and as the common structure units like the pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI) are owned, the steroid saponin compound in the medicinal materials of trillium or paris polyphylla has remarkable effects of treating any hepatitis or liver injury in alcoholic hepatitis or liver injury, nonalcoholic hepatitis or liver injury, alcoholic fatty liver, non-alcoholic fatty liver, hepatic fibrosis or liver cirrhosis.

The invention discloses application of melanin extracted from auricularia auricula in a liver-protection product, and belongs to the technical field of medicines and food. According to the applicationdisclosed by the invention, protein in an auricularia auricula fruiting body is destroyed through strong acid, and the melanin is precipitated out through an alkali solution to obtain precipitants, and the precipitants are collected so as to obtain a melanin crude extract; purifying the melanin crude extract by sequentially using ethanol, ethyl acetate and acetone to obtain the purified melanin;using the melanin in a liver-protection product (including a liver-protection medicine or liver-protection food), wherein the melanin component accounts for 0.1 to 100 percent by weight of the liver-protection product. According to the application of the melanin extracted from the auricularia auricula in the liver-protection product disclosed by the invention, the melanin extracted from the auricularia auricula is used in the liver-protection product, so that the effective liver-protection component, namely the melanin, has obvious effects on prevention or treatment of virus hepatitis, drug-induced liver injury, alcohol liver and fatty liver. In addition, the application of the melanin extracted from the auricularia auricula in the liver-protection product disclosed by the invention has the advantages of simple and feasible process and low cost, and is suitable for industrially mass production.

The invention relates to a method for preparing dehydrodiconify alcohol or an ethyl acetate extract of semen hertospermi with dehydrodiconify alcohol as the main active ingredient and application thereof in hepatoprotective drugs for preventing or treating liver damage. The extraction method includes the following steps that pulverized semen hertospermi is pulverized and extracted with ethanol, the extract is extracted with ethyl acetate, and concentration under reduced pressure is conducted to form the extract. It is found through experiments that dehydrodiconify alcohol can significantly reverse the increase of liver function levels such as ALT and AST in the serum of ANIT-induced cholestasis SD rats, the decrease of bile flow and liver lesions, and has a significant anti-liver damage protective effect; dehydrodiconify alcohol acts mainly by modulating downstream gene expression based on activation of an FXR target. The application range of dehydrodiconify alcohol and the ethyl acetate extract of semen hertospermi is broadened, and the method for preparing dehydrodiconify alcohol or the ethyl acetate extract of semen hertospermi with dehydrodiconify alcohol as the main active ingredient and the application thereof in the hepatoprotective drugs for preventing or treating liver damage have important application value and economic benefit for the development of FXR agonistic drugs and anti-liver damage protective drugs.

The invention discloses a standardized extract of red jujube leaves and its preparation method and application. The extract contains the following components: oleic acid-3-O-trans-p-coumaroyl ester 134.96 μg / g; Acid-3-O-cis-p-coumaroyl ester 5.27μg / g; benzoic acid 6.75μg / g; 2,4-dihydroxyphenol 6.47μg / g; p-hydroxybenzoic acid 77.14μg / g; o-hydroxybenzoic acid Benzoic acid 2.24μg / g; rutin 25.13μg / g; p-hydroxybenzaldehyde 10.25μg / g; maslinic acid-3-O-trans-p-coumaroyl ester 3.84μg / g; p-hydroxycis-cinnamic acid 1.71μg / g; p-hydroxy trans-cinnamic acid 9.38μg / g; 3,4-dihydroxybenzoic acid: 1.85μg / g. Activity test results show that the red date leaf extract has hepatoprotective activity and can be used to make hepatoprotective drugs.

The invention relates to a new rotenone-type flavonoid compound and its preparation method and application. The structural formula of the new rotenone-type flavonoid compound is as follows:. The new rotenone-type flavonoids have a novel structure, simple extraction and separation methods, and significant hepatoprotective activity, providing an important experimental basis and theoretical basis for the discovery of new hepatoprotective drugs from Arrowflower.

The invention discloses a mixed-source terpenoid compound with the function of protecting the liver. The mixed-source terpenoid compound has the structures shown in formula (I) and formula (II): experiments prove that the formula (I) and formula (II) of the present invention The mixed-source terpenoids shown in (II) have significant protective effects on the liver cell damage caused by paracetamol, suggesting that the mixed-source terpenoids shown in formula (I) and formula (II) can be used as liver-protecting drugs with good research and development prospects.

The invention relates to the application of steroidal saponin compounds in Trillium genus or Patricia genus medicinal materials in the preparation of liver-protecting or liver-protecting medicines. The steroidal saponins in the prepared Trillium genus or Patricia genus medicinal materials themselves are pinanogenin‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→2)‑β‑ D ‑Glucoside (i.e. papaya saponin VI), pinanogenin‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→4)‑[α‑ L ‑rhamnopyranosyl (1→2)]‑β‑ D ‑Glucosides and Pinogenin‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→4)‑α‑ L ‑Rhamnopyranosyl (1→4)‑[α‑ L ‑rhamnopyranosyl (1→2)]‑β‑ D One or more of ‑glucosides (i.e. papaya saponin VII), due to the common innosapogenin ‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→2)‑β‑ D ‑glucoside (i.e. saponin Ⅵ) and other structural units, and in the human body have the ability to treat alcoholic hepatitis or liver damage, non-alcoholic hepatitis or liver damage, alcoholic fatty liver, non-alcoholic fatty liver, liver fibrosis or Significant efficacy of either hepatitis or liver damage in cirrhosis.

The invention discloses a Phlomis maximowiczii extract, as well as an extraction method and application thereof in preparation of antioxidant drugs and hepatoprotective drugs, and belongs to the technical field of medicines. The Phlomis maximowiczii extract contains a petroleum ether extract, an ethyl acetate extract and an n-butanol extract. The extraction method comprises the following steps: (1) collecting whole plants of Phlomis maximowiczii, washing, drying in a dark place, grinding and then extracting by soaking in methanol, recovering methanol to obtain a total extract; (2) dispersing the total extract in an ethanol aqueous solution, adding petroleum ether for extraction, and recovering petroleum ether to obtain the petroleum ether extract; (3) adding ethyl acetate into the solution for extraction after petroleum ether extraction, and recovering ethyl acetate to obtain the ethyl acetate extract; and (4) adding n-butanol into the solution after ethyl acetate extraction and recovering n-butanol to obtain the n-butanol extract. The Phlomis maximowiczii extract has antioxidant and hepatoprotective effects and can be used for preparing antioxidant and hepatoprotective health foods or drugs.

The present invention provides a sodium valproate compound preparation and a use thereof. Aiming at adverse reactions of liver function damages or memory impairment, etc. caused by sodium valproate, the adverse reactions are prevented and treated by adding a common hepatoprotective drug of polyene phosphatidylcholine, toxic and side effects are reduced, and problems of patient administration convenience and compliance are solved. Besides, the sodium valproate compound preparation is simple in technology, convenient for mass production, and safe and reliable in product quality.

The invention discloses a compound Dai medicine extract with liver-protecting effect and a preparation method thereof. The compound Dai medicine extract is extracted from Dai medicines, such as Clerodendranthus spicatus (Thunb.)C.Y.Wu ex H.W.Li, Cassytha filiformis Linn. and Arcangelisia loureiri (Pier.)Diels. The invention also discloses a method for extracting the compound Dai medicine extract. The compound Dai medicine extract disclosed by the invention can be used for preparing liver-protecting medicines or health-care products.

The invention belongs to the field of biotechnology, and in particular relates to the preparation of geranium wilfordii Maxim. polysaccharide and its application in the development of liver-protecting drugs. The present invention adopts concanavalin A-induced immune liver injury model to investigate its hepatoprotective activity. Experimental results show that geranium polysaccharides can significantly reduce liver function indicators in mice with liver damage, and can be used to develop liver-protecting drugs, especially drugs for the treatment of immune liver damage. This invention is of great significance to the further development and utilization of geranium.