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Rhizoma saururi herba saururi lignans extract, preparation and uses thereof

A kind of extract, technology of three white grass, applied in the field of three white grass lignan extract

Inactive Publication Date: 2008-09-03
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, there is no related research on the extraction process of specifically enriching the lignans in Sanbaicao

Method used

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  • Rhizoma saururi herba saururi lignans extract, preparation and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Dry 10kg of Sanbai herbal material, pulverize, extract with 10 times of 80% ethanol and heat and reflux for 3 times, filter and combine the reflux extracts, and concentrate the extracts under reduced pressure at 60°C to make the ethanol content about 10%. The volume is 10L, the concentrated extract is placed at room temperature overnight, filtered, and the supernatant is taken. After the supernatant is evaporated under reduced pressure until there is no alcohol smell, after reaching a volume of about 8 liters, it is extracted with hexane for degreasing to the hexane extract The color becomes lighter. After the extraction, the pH value of the drug solution is adjusted to 10.0 with sodium bicarbonate, and the extraction is continued with ethyl acetate until the color of the ethyl acetate extract layer becomes lighter. The ethyl acetate extracts are combined and the ethyl acetate extracts are reduced in pressure Concentrate to about 1 / 3 of the volume of the extract, wash 3 tim...

Embodiment 2

[0025] Dissolve the Saururus chinensis extract obtained in Example 1 with 150 mL of 95% ethanol under reflux, slowly add distilled water while it is hot, and shake well while adding, until the ethanol concentration is about 45% (that is, when the water is dripped (Slightly turbid), shake well, seal, cool to room temperature, change to place in the refrigerator overnight, wait for crystals to precipitate, filter, take crystals to obtain crystal I; the mother liquor is pressurized and concentrated to dryness, and about 90mL of 95% ethanol is added Dissolve under reflux, slowly add water and repeat the above operation for secondary recrystallization to obtain crystal II; combine crystals I and II to obtain 48 g of Saururus chinensis extract with a lignan content of 87%.

Embodiment 3

[0027] After dissolving the Saururus chinensis lignan extract obtained in Example 1 with as little absolute ethanol as possible, it was mixed into 100 mesh silica gel. The silica gel used was twice the weight of the extract. The ethanol was evaporated on a water bath and the extract was stirred. The silica gel was refluxed with acetic acid and ethanol for 2 to 3 times, the ethyl acetate reflux extracts were combined, and concentrated under reduced pressure to obtain 65 g of Saururus chinensis extract with a lignan content of 73%.

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Abstract

The invention relates to a Chinese lizarbtail herb extract with the lignan content of higher than 50 percent, a preparation method thereof and applications in liver protection drugs and health care products, and the Chinese lizarbtail herb extract which is rich in lignan ingredient can be obtained by ethanol extraction, organic solvent extraction and a series of purification steps of Chinese lizarbtail herb medicinal material.

Description

Technical field [0001] The invention relates to a Saururus chinensis lignan extract with a lignan content of at least 50% or more, a preparation method thereof and its application in liver protection medicines. Background technique [0002] Saururus Chinensis (Lour.) baill is a perennial herb in the Saururus family. The whole herb is used as medicine. It has the effects of clearing away heat, detoxifying, diuresis and reducing swelling. It is mainly distributed in the south-central and southwestern regions of my country. It can be harvested in all seasons and is rich in resources. Saururus chinensis contains a variety of biologically active ingredients. The volatile oils, flavonoids, lignins, alkaloids, tannins, polysaccharides, etc. have been isolated from it. These ingredients have been found to have anti-inflammatory, detoxifying, and hypoglycemic properties. , Liver-protecting, diuretic and other activities. [0003] Lignan is one of the main chemical components in Saururus c...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K9/20A61K9/48A61P1/16
Inventor 张树祥熊国裕
Owner BEIJING SUNHO PHARMA
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