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Lathyrane compound and extraction method and application thereof

A kind of compound, the technology of diterpane, which is applied in the field of diterpene type compound and its extraction, and can solve the problem of immune damage that has not been reported and the like

Active Publication Date: 2020-07-28
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The diterpenoid compound is the main component contained in it. At present, there are many studies on its anti-tumor and anti-tumor multidrug resistance, and the anti-inflammatory use and treatment of the extract from Fructus Rhizome and the diterpenoid compound Autoimmune diseases and immune damage have not been reported

Method used

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  • Lathyrane compound and extraction method and application thereof
  • Lathyrane compound and extraction method and application thereof
  • Lathyrane compound and extraction method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The method for extracting the diterpenoid type compound is characterized in that it comprises the following steps:

[0039] (1) Take the dry seeds (10.0 kg) of Euphorbiaceae Euphorbia as raw material, add petroleum ether reagent 1 mass times of the raw material after crushing, soak overnight at room temperature, degrease, filter the petroleum ether liquid and use the volume fraction as 85% ethanol aqueous solution was extracted, and the solvent was recovered from the extract under reduced pressure to obtain 85% ethanol layer extract (289 g). And medicated powder then adds the volume fraction of 6 mass times and is 95% ethanol aqueous solution, reflux extracts 3 times, extracts 2 hours each time, merges gained extract, reclaims solvent under reduced pressure, obtains 95% ethanol layer extract (718g) after concentrating;

[0040] (2) Disperse the 95% ethanol layer extract into 4 mass times of water, extract with ethyl acetate, and recover the solvent from the ethyl acetat...

Embodiment 2

[0066] The method for extracting the diterpenoid type compound of a thousand gold, comprises the steps:

[0067] (1) Using the dry seeds of Euphorbiaceae Euphorbia sativa as raw material, add petroleum ether reagent 1 mass times of the raw material, soak overnight at room temperature, degrease, filter the petroleum ether liquid and use ethanol aqueous solution with a volume fraction of 70%. Extraction, the solvent is recovered from the extract under reduced pressure, and a 70% ethanol layer extract is obtained. And medicine powder is then added 3 times by mass volume fraction is 95% ethanol aqueous solution, reflux extracts 2 times, extracts 2 hours each time, merges the obtained extract, reclaims solvent under reduced pressure, obtains 95% ethanol layer extract after concentrating;

[0068] (2) Disperse the 95% ethanol layer extract into 2 mass times of water, extract with ethyl acetate, and recover the solvent from the ethyl acetate extract under reduced pressure to obtain t...

Embodiment 3

[0071] The method for extracting the diterpenoid type compound of a thousand gold, comprises the steps:

[0072] (1) Using the dry seeds of Euphorbiaceae Euphorbia as raw material, add petroleum ether reagent of 5 times the mass of the raw material, soak overnight at room temperature, degrease, filter the petroleum ether liquid and use 85% ethanol water solution for volume fraction Extraction, the solvent is recovered from the extract under reduced pressure to obtain an 85% ethanol layer extract. The medicinal powder is then added with 8 mass times volume fraction of 95% ethanol aqueous solution, reflux extraction 4 times, each extraction is 2 hours, the resulting extracts are combined, the solvent is recovered under reduced pressure, and the 95% ethanol layer extract is obtained after concentration;

[0073] (2) Disperse the 95% ethanol layer extract into 6 mass times of water, extract with ethyl acetate, and recover the solvent from the ethyl acetate extract under reduced pr...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine extraction, and discloses a lathyrane compound and an extraction method and application thereof. The compound has a structure of (I), wherein R1 and R2 are as described in the claims and the specification. The compound and the composition thereof have an inhibiting effect on nitric oxide generated by LPS-induced human macrophages (RAW264.7), which indicates that the compound has an anti-inflammatory effect and can be used for preparing anti-inflammatory drugs for treating autoimmune diseases or immune injuries.

Description

technical field [0001] The invention relates to the field of extraction of traditional Chinese medicines, and relates to a diterpene-type compound and its extraction method and application. Background technique [0002] Qianjinzi is the dry and mature seed of Euphorbia lahyris, a plant of the Euphorbiaceae family. It is widely distributed in regions, and its main producing areas are Henan, Hebei, Zhejiang, Sichuan, Jilin and other provinces. Harvest when the fruit is ripe in summer and autumn, remove impurities, and dry. Qianjinzi is a folk traditional Chinese medicine. Warm in nature and pungent in taste (poisonous), returns liver, kidney, large intestine channel. It has the function of purging and dispelling water, breaking blood and eliminating syndrome; externally treating ringworm and eroding warts. It can be used for the treatment of constipation, edema, phlegm retention, stagnant fullness, blood stasis and amenorrhea; external treatment of stubborn tinea and warts....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/18C07C69/614C07C69/618C07C69/16C07C67/56C07C67/52A61K31/22A61K31/216A61P29/00A61P37/00A61P19/02A61P9/00A61P17/00A61P1/00A61P31/04A61P25/00A61P1/16
CPCC07C69/18C07C69/614C07C69/618C07C69/16C07C67/56C07C67/52A61P29/00A61P37/00A61P19/02A61P9/00A61P17/00A61P1/00A61P31/04A61P25/00A61P1/16C07C2603/38Y02A50/30
Inventor 陈丽霞李华张翠云吴艳丽
Owner SHENYANG PHARMA UNIVERSITY
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