30results about How to "Good functional group tolerance" patented technology

Provided is a method for catalyzing alcohol dehydrogenation silicon alkylation by using azacyclo-cabbeen. Catalyst azacyclo-cabbeen is dissolved in an organic solvent or directly placed in a schlenk tube (Schlenk tube) and a nuclear magnetism tube, silane and alcohol are sequentially added, a molar ratio of the silane to the alcohol is 1:1-2, a molar ratio of the catalyst azacyclo-cabbeen to the silane is 0.002-0.05:1, reaction is carried out at the normal temperature for 0.5-24h, then a solvent is extracted under a vacuum condition or distillation or column chromatography purification is directly carried out, and the alcohol dehydrogenation silicon alkylation can be carried out to prepare siloxane. The method has the advantages of using small organic molecule azacyclo-cabbeen to serve as a catalytic agent to replace a metal catalyst, is cheap in raw material, easy to prepare, soft in catalysis condition, high in catalytic activity, good in selectivity, easy in aftertreatment and wide in applicable scope of substrate silane, has good functional group tolerance, is single in reaction product, and can efficiently and selectively obtain the siloxane.

High activity metal nanoparticle catalysts, such as Pd or Pt nanoparticle catalysts, are provided. Adsorption of metal precursors such as Pd or Pt precursors onto carbon based materials such as graphene followed by solventless (or low-solvent) microwave irradiation at ambient conditions results in the formation of catalysts in which metal nanoparticles are supported on i) the surface of the carbon based materials and ii) in / on / within defects / holes in the carbon based materials.

The invention discloses a method for preparing a polyimidazoline compound. The method comprises the following step: carrying out a polymerization reaction on a binary isonitrile group compound, a binary sulfimide compound and a catalyst in an organic solvent, thereby obtaining the polyimidazoline compound, wherein the polymerization catalyst comprises cuprous chloride and triphenylphosphine. The method is simple to operate, efficient in reaction, free of heating and energy-saving and environmental-friendly, and can be carried out at the room temperature. The invention further discloses the polyimidazoline compound prepared by using the method. The polyimidazoline compound has good workability and high thermal stability.

The present invention relates to the technical field of organic synthesis, in particular to a double silicon compound, its preparation method and application. The molecular structure of the double silicon compound is as follows: wherein, R 1 , R 2 are aryl or alkyl, which can be the same or different; R 3 , R 4 , R 5 Any one of aryl group, alkyl group and hydrogen atom, which can be the same or different, R 3 , R 4 , R 5 Up to two hydrogen atoms at the same time, R 6 Any of aryl group, alkyl group, heteroatom and hydrogen atom. The preparation method of the present invention realizes the ring-opening metathesis reaction of four-membered ring silicon and silane, is a new reaction mode, and provides a simple and efficient method for synthesizing double silicon compounds, especially two silicons containing silicon hydrogen It can be used to synthesize polymers under circumstances, and has very great application prospects.

The invention provides a method for synthesizing a 2,3-dihydrobenzofurans compound. The method comprises the following steps: dissolving aromatic iodide, an epoxy compound, a palladium catalyst, a phosphine ligand and a norborene derivative in an organic solvent together; then carrying out stirring reaction at the temperature of 30-120 DEG C; and carrying out separation and purification after reaction to obtain the 2,3-dihydrobenzofurans compound. By the method, the 2,3-dihydrobenzofurans compound can be synthesized efficiently, economically and environmentally friendly. The method is gentle in condition, good in substrate universality and high in yield, and the prepared 2,3-dihydrobenzofurans compound is widely applied to the fields of medicinal chemistry and organic chemistry.

The invention discloses a method for synthesizing alkyne sulfone compounds with terminal alkyne and sulfonyl hydrazide. This method synthesizes a series of alkynyl sulfone compounds through the oxidative cross-coupling reaction of terminal alkynes and sulfonyl hydrazides. Functional group tolerance and other advantages. The compounds synthesized by this method were screened for anti-tumor activity in vitro, and the experimental results showed that most of the compounds had strong inhibitory activity on tumor cells.

The invention discloses a 4-perfluoroalkyl substituted pyrimidine compound, a preparation method and application thereof. In the present invention, alkali additives and solvents are added to the reaction raw materials mixed with perfluoroalkyl substituted alkyne compounds and amidine hydrochloride, stirred and reacted for 1 to 24 hours in an air atmosphere at 70°C, and determined by TLC detection The reaction process, the reaction product is obtained after the reaction is completed, the reaction product is washed, extracted and dried, and then separated by column chromatography to obtain a 4-perfluoroalkyl substituted pyrimidine compound. The preparation method of the present invention has mild reaction conditions, does not need expensive transition metal catalysts, only uses inorganic alkali cesium carbonate as an additive, has the characteristics of simple post-treatment, green steps, low pollution, and high economic benefits, and the prepared compound is a novel multi-substituted pyrimidine molecule. It has good application prospects in the fields of new medicine and new material development.

The invention provides a method for photocatalytically synthesizing alkaloids, the alkaloids include indole fused rings and indole spiro compounds, the process is as follows: nitrogen aryl acrylamide is used as raw material to react with peroxide under photocatalysis Synthesize 3-acetal 2-indolinone compounds, obtain 3-formyl-2-indolinone compounds through hydrolysis, and further reduce and synthesize alkaloids. This method has a mild route and high efficiency. The reaction can occur under light at room temperature, the conditions are mild, and it has good substrate versatility and functional group tolerance.

The invention relates to an asymmetric diaryl sulfone compound and a preparation method thereof, and discloses diaryl sulfone into which aryl fluoborate catalyzed by cuprous chloride participates at room temperature, and a preparation method thereof. Available nontoxic aryl sulfinic acid sodium is selected as a substrate, and a low-cost reaction system is selected to develop coupling reaction of aryl sulfinic acid sodium and aryl potassium fluoborate catalyzed by cuprous chloride, so as to synthesize asymmetric diaryl sulfone. The diaryl sulfone synthesis method is economic and effective, mild in condition, short in reaction time, high in reaction yield and low in cost, and has good practicability and economic value.

The invention discloses 2-hydroxypyridine compounds, their synthesis method and application. Using enaminone as a starting material and tempo salt as an oxidizing agent, 2-hydroxypyridine compounds are generated through oxidation reaction and coupling cyclization reaction under heating conditions. The reaction has strong functional group compatibility, the yield is as high as 80%, and the product has functional group diversity. It can be used as a precursor for organic synthesis, and the 2-position hydroxyl group and 6-position hydrogen atom in the structure can be further functionalized to obtain drug molecular skeletons or compounds with potential biological activity.