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1,1-diarylalkane derivative preparation method

A technology for diarylalkanes and derivatives, which is applied in 1 field and achieves the effects of high-efficiency new bond formation ability, mild reaction conditions and simple operation

Active Publication Date: 2019-09-20
NANCHANG HANGKONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, current styrene difunctionalization reactions involving alkyl NHP esters mainly focus on the construction of C(sp3)-C(sp3) / C(sp3)-heteroatom bonds, while styrene and (hetero)arenes are bonded via C (sp2)-H breaks, and the alkylation reaction of building C(sp3)-C(sp3) / C(sp3)-C(sp2) bond has not been reported in the prior art

Method used

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Embodiment Construction

[0033] Below in conjunction with specific embodiment, the present invention is described in further detail. Hereinafter, unless otherwise specified, the methods described are conventional methods in the art, and the reagents used can be purchased through commercial channels.

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Abstract

The invention discloses a 1,1-diarylalkane derivative preparation method, wherein a C(sp3)-C(sp3) / C(sp3)-C(sp2) bond is constructed under light oxidation-reduction catalytic conditions by using an olefin-based compound, (hetero) aromatic hydrocarbon and a N-hydroxy phthalimide ester compound as raw materials so as to achieve the 1,2-difunctionalization reaction of olefin, such that a series of 1,1-diaryl alkane derivatives are prepared.

Description

technical field [0001] The application belongs to the technical field of organic synthesis, and in particular relates to a preparation method of 1,1-diaryl alkane derivatives. Background technique [0002] Carboxylic acid derivatives-N-hydroxyphthalimide alkyl esters (alkyl NHP esters) have become a very important alkylating agent in organic synthesis, not only by using cheap, readily available and stable Fatty acids are simple to prepare, and can easily generate alkyl radicals by decarboxylation under photoredox catalysis, transition metal catalysis, etc. (1) Org.Lett.2018, 20, 6659-6662; 2) Org.Lett.2018 , 20, 888-891; 3) Org. Lett. 2018, 20, 3496-3499; 4) ACS Catal. 2018, 8, 7489-7494; 5) Org. Lett. 2018, 20, 1546-1549; 6) Org.Lett.2018, 20, 224-227; 6) Chem.Eur.J.2018, 24, 4552-4555; 7) Angew.Chem.Int.Ed.2017, 56, 3708-3711; 9) J. Org. Chem. 2015, 80, 6025-6036; 10) NATURE COMMUNICATIONS, (2018) 9: 5215, etc.). In recent years, alkyl NHP esters have been used by organ...

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Application Information

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IPC IPC(8): C07C41/30C07C213/08C07D207/333C07D209/08C07D209/12C07D209/24C07D409/06C07D471/06C07B37/02C07C217/80C07C43/21
CPCC07D209/12C07D209/24C07D209/08C07D409/06C07D471/06C07D207/333C07C213/08C07C41/30C07B37/02C07C2603/74C07C217/80C07C43/21
Inventor 欧阳旋慧梁云燕宋仁杰李金恒
Owner NANCHANG HANGKONG UNIVERSITY
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