278 results about "Spiro compound" patented technology

The light emitting device of the present invention relates to a light emitting device which is characterized in that it is a device with an emissive substance present between an anode and cathode, and which emits light by means of electrical energy, and said device has a least one type of compound denoted by (a) to (d) below. (a) A compound having a plurality of 1,7-phenanthroline skeletal structures (b) A benzoquinoline derivative (c) A spiro compound represented by general formula (1) A1 and A2 are each selected from single bonds, substituted or unsubstituted alkyl chains, ether chains, thioether chains, ketone chains and substituted or unsubstituted amino chains. However, A1<> A2. Z represents carbon or silicon. R1 to R16 are each selected from hydrogen, alkyl group, cycloalkyl group, aralkyl group, alkenyl group, cycloalkenyl group, alkynyl group, hydroxyl group, mercapto group, alkoxy group, alkylthio group, aryl ether group, aryl thioether group, aryl group, heterocyclic group, halogen, haloalkane, haloalkene, haloalkyne, cyano group, aldehyde group, carbonyl group, carboxyl group, ester group, carbamoyl group, amino group, nitro group, silyl group, siloxanyl group and a cyclic structure formed with an adjacent substituent. (d) A tetraphenylmethane derivative represented by general formula (2) R17 to R36 are each selected from hydrogen, alkyl group, cycloalkyl group, aralkyl group, alkenyl group, cycloalkenyl group, alkynyl group, hydroxyl group, mercapto group, alkoxy group, alkylthio group, aryl ether group, aryl thioether group, aryl group, heterocyclic group, halogen, haloalkane, haloalkene, haloalkyne, cyano group, aldehyde group, carbonyl group, carboxyl group, ester group, carbamoyl group, amino group, nitro group, silyl group, siloxanyl group and a cyclic structure formed with an adjacent substituent. However, at least one of R17 to R36 is selected from substituents represented by general formula (3). -X-Ar (3) X is a single bond or is selected from the following, and Ar denotes a condensed aromatic ring or heteroaromatic ring. In the case where X is phosphorus oxide, then Ar represents an aromatic hydrocarbon or heteroaromatic ring. n is an natural number.

The present invention relates to 1-oxa-3,8-diaza-spiro[4.5]decan-2-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of treating a disease condition associated with a monoamine receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.

The present invention relates to a novel class of substituted spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.

The Spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereof

Disclosed is an electric double layer capacitor that comprises: a polarizable electrode containing a carbon material having graphite-like microcrystalline carbon; and an electrolyte containing a spiro compound represented by the general formula

(where A represents a spiro atom having an sp³ hybrid orbital, Z¹ and Z² each represent a group of atoms forming a saturated ring or unsaturated ring in which the number of ring atoms including A is four or more, and X⁻ represents a counter-anion). According to the present invention, an electric field activation type electric double layer capacitor can be obtained that simultaneously achieves improved volumetric capacitance density, improved resistance, and improved withstand voltage.

A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11 β-hydroxy-Steroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, e.g. the metabolic syndrome.

Provided are a novel spiro compound, and an organic luminescence device using the spiro compound and having an optical output with an extremely high efficiency and a high luminance, and an extremely high durability. The Spiro compound is represented by the following general formula [I]:

(wherein R₁, R₂, R₃, and R₄ represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, a substituted amino group, a cyano group, or a halogen atom, and R₁, R₂, R₃, and R₄ may be identical or different from each other; and Ar₁ and Ar₂ represent a substituted or unsubstituted condensed polycyclic aromatic group or a substituted or unsubstituted condensed polycyclic heterocyclic group, which may be identical or different from each other.)

An electrolytic solution for electric double layer capacitor characterized in that a Spiro compound of formula (1) is contained as an electrolyte in an aprotic solvent and that the electric conductivity thereof at −40° C. is 0.85 mS/cm or higher.

This electrolytic solution for electric double layer capacitor realizes a high dissolution of electrolyte in solvent and exhibits excellent conductivity and electrostatic capacity over a wide temperature range from low temperature to high temperature. Further, the electrolytic solution for electric double layer capacitor exhibits high resistance to voltage and even under long-term high voltage load, exhibits suppressed lowering of electrostatic capacity to thereby excel in long-term stability.

The present invention aims to provide a novel SCD inhibitor.

The present invention relate to SCD inhibitor comprising A compound represented by the formula (I)

wherein

R is an optionally substituted cyclic group or an optionally substituted carbamoyl group, provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl group;

ring A is an optionally further substituted pyridazine ring;

R₁, R₂, R₃, R₄, R₁₁, R₁₂, R₁₃ and R₁₄ are each independently a hydrogen atom or a substituent, or R₁ and R₁₁ in combination, R₂ and R₁₂ in combination, R₃ and R₁₃ in combination, or R₄ and R₁₄ in combination optionally form an oxo group, or R₂ and R₄ in combination optionally form a bond or an alkylene cross-linkage;

m and n are each independently an integer of 0 to 2;

ring B is an optionally substituted ring, provided that the two atoms constituting ring B, which are adjacent to the spiro carbon atom, are not oxygen atoms at the same time, or a salt thereof, or a prodrug thereof.