40results about How to "Easy and green post-processing" patented technology

The invention discloses a preparation method of a 1,2-substituted benzimidazole derivative. The preparation method comprises the following steps: uniformly mixing an N-phenyl amidine derivative, a nitrine derivative, an acid compound, a catalyst, a metal salt and an organic solvent; and performing a reaction for 10-13h at 78-82 DEG C in an air atmosphere to obtain the 1,2-substituted benzimidazole derivative. The method disclosed by the invention can be used for synthesizing a compound with a benzimidazole derivative framework, which cannot be synthesized by other methods. The used raw materials are easily available, and the preparation method is high in yield, mild in reaction condition, wide in primer range, small in catalyst dosage, strong in reaction specificity and simple and green in post-treatment, and the utilization ratio of atoms reaches up to 90% and above.

The invention discloses a preparation method of a 2,4-di-substituted pyrrole derivative. The reaction equation is shown in the description. By adopting the method, a pyrrole derivative with a plurality of substituents which is difficult to obtain with other methods can be synthesized.

The invention discloses a synthetic method for a 1,3,5-triarylbenzene compound. The method comprises the following steps: dissolving a chalcone derivative and inorganic alkali in dimethyl sulfoxide, carrying out reaction at 40 to 80 DEG C in the air for 3 to 8 hours, and carrying out separation and purification so as to obtain the 1,3,5-triarylbenzene compound, wherein a molar ratio of the chalcone derivative to the inorganic alkali is 1: 1-6; every mole of the chalcone derivative requires 4 to 8 mL of dimethyl sulfoxide; and the chalcone derivative has a general structural formula described in the specification, wherein Ar1 and Ar2 are aryl groups. The synthetic method for the 1,3,5-triarylbenzene compound provided by the invention has the following advantages of easily-available raw materials, simple operation, mild reaction conditions, no need of any transition metal catalyst, strong reaction specificity, strong applicability to a basic-group-contained substrate, no generation of waste products like halogen or boric acid, and simple, convenient and green after-treatment.

The invention discloses a multi-substituted 2-hydroxyl-1,4-benzoxazine derivative, the structural formula of which is as follows: the present invention synthesizes a multi-substituted 2-hydroxyl-1,4-benzoxazine derivative which cannot be synthesized by other methods. Oxazine derivatives have far-reaching significance from the perspectives of organic synthesis and medicinal chemistry, and the raw materials used in the method of the present invention are easy to get, the yield is high, the reaction conditions are mild, the reaction time is short, the substrate range is wide, and the reaction is specific. Strong, easy to post-treatment and green.

The invention discloses a preparation method of a 1-amino indole derivative. The method comprises the steps of mixing a phenylhydrazine hydrochloride derivative, a diazo compound, an aldehyde or ketone compound, a catalyst, alkali and an organic solvent evenly; and carrying out condensation reaction in air or nitrogen at 80-100 DEG C for 2-12h to obtain the 1-amino indole derivative. The 1-amino indole derivative which cannot be synthesized by other others can be synthesized, and the used raw materials are available, high in yield, mild in reaction condition, wide in substrate range, high in reaction specificity, and simple and green in aftertreatment.

The invention discloses a preparation method of [1,2,4]oxadiazinoindoline-3-one derivatives, comprising the following steps: (1) preparing an o-nitrophenylacetylene compound, a catalyst and a first organic After the solvents are mixed, react at room temperature for 3-6h; (2) add α-halogenated hydroxamate compound, sodium carbonate and hexafluoroisopropanol to the material obtained in step (1), and react for 10 h at room temperature ‑12h; or mix o-nitrophenylacetylene compound, catalyst, α‑halogenated hydroxamate compound, sodium carbonate and hexafluoroisopropanol and react at 55‑65°C for 10‑12h. The invention can synthesize [1,2,4]oxadiazinoindoline-3-one derivatives with various substituents which are difficult to synthesize by other methods, and has far-reaching significance from the perspective of organic chemistry.

The invention discloses a polysubstituted 2-pyrrolopyridine derivative. The derivative has a structure shown in a formula in the specification, wherein in the formula, R1, R2, R3, R4, R5, R6, R7 and R8 are selected from any one of hydrogen atoms, halogen atoms, alkyl, aryl, substituted aryl, acyl, amino, nitro and alkoxy. The invention also discloses a preparation method of the polysubstituted 2-pyrrolopyridine derivative. The polysubstituted 2-pyrrolopyridine derivative shown in the formula is obtained at high yield after completing heating reaction of N-propargyl enaminone in a solvent in the presence of appropriate alkali. The polysubstituted 2-pyrrolopyridine derivative and the preparation method have the beneficial effects that the reaction conditions are mild; the reaction time is short; the range of substrates is wide; the reaction specificity is strong; the yield is high; aftertreatment is simple and convenient to carry out.

The invention discloses a preparation method of an N-(2-pyridyl / pyrimidyl)indole derivative. The preparation method of the N-(2-pyridyl / pyrimidyl)indole derivative comprises the following steps: mixing a 2-substituted phenylaminopyridine / pyrimidine derivative, an alkenyl azide compound, a catalyst, an oxidizing agent, alkali and an organic solvent uniformly, heating to 60 to 80 DEG C under nitrogen or air, performing a cyclization reaction for 18 to 24 hours, cooling to room temperature after the reaction, and performing concentration and column chromatographic purification to obtain the N-(2-pyridyl / pyrimidyl)indole derivative. By the preparation method, the N-(2-pyridyl / pyrimidyl)indole derivative with various substituent groups which cannot be synthesized according to other methods canbe synthesized; furthermore, the used raw materials are easily available, the yield is high, the reaction condition is mild, the reaction time is short, the substrate range is wide, the reaction specificity is high and aftertreatment is simple, convenient and green.