The invention discloses a high-yield production process for a 1,3-diphenyl propanedione compound. The production process comprises the steps that a benzoate compound A, a catalyst and a solvent I areadded into a reaction kettle, then an acetophenone compound B is dropwise added into the reaction kettle at the set temperature for reaction, and after reaction, a final product is prepared through acidification, washing, desolvation and recrystallization. The production process has the characteristics that a mixed basic catalyst is adopted, compared with sodium methylate and a traditional process, the yield is increased by 10-15% and is greater than or equal to 85.0%, the production operation is easy, the environmental pollution is small, the product color is light, the distinctive aromatic odor is achieved, the quality is good, the market competitiveness is high, and the industrialization promotion is easy.