The invention relates to a method for comprehensive utilization of edible fungus residues. The method comprises the steps of 1, conducting steam treatment on waste bacteria sticks after impurity removal and smashing, so that pretreated fungus residues are obtained; 2, adjusting the water content and pH of the pretreated fungus residues, and building a heap for solid aerobic fermentation, so that primarily fermented fungus residues are obtained; 3, mixing the primarily fermented fungus residues with water in proportion, conducting aerated fermentation constantly, conducting filtration, and drying and smashing filter residues to obtain vegetable cultivation base fertilizer, wherein filtrate serves as an edible fungus growth promotion and yield increase agent. Mycoprotein, polysaccharide, oligosaccharide, enzymes, microorganisms and other bioactivators rich in fungus residues are fully utilized, mycoprotein, cellulose and lignin are further degraded into substances capable of being absorbed by edible fungi easily, the edible fungus growth promotion and yield increase agent which contains various physiological activators and nutrients and can promote edible fungus growth is obtained through extraction, and filter residues are used for preparing a vegetable seedling culture medium.