The invention relates to a medicinal preparation characterized by a special
physical shape, in particular to a method for preparing
adhesive pellets by
extrusion and spheronization, which comprises the following steps: (1) sieving a medicament and a filler with a 100-mesh
sieve and uniformly mixing the medicament and the filler according to a medicament to filler weigh ratio of 1-2:10-30, adding an
adhesive in an amount which is 0.5 to 30 times the weight of the added medicament to prepare a soft material, extruding, spheronizing,
drying and sieving with a 24-to-40-mesh
sieve, and obtaining the medicament-loaded
pellets; or dissolving the medicament in the
adhesive in an amount which is 0.5 to 30 times the weight of the medicament, adding the filler according to a medicament to filler weigh ratio of 1-2:10-30 to prepare the soft material, extruding spheronizing,
drying and sieving with the 24-to-40-mesh
sieve and obtaining the medicament-loaded
pellets; and (2), placing the medicament-loaded pellets in a
coating pan, adding powdered adhesive according to a medicament to adhesive weigh ratio of 1-2:10-20,
wetting by spraying a proper amount of water or
ethanol at concentration of 40 to 60 percent,
coating the adhesive on the outer layer of the medicinal pellets at the temperature of 65 to 80 DEG C by a
powder lamination
coating process, placing the pellets in an oven at 40 DEG C and
drying the pellets for 12 hours.